The Recombinant Protein ephB4-Fc Changes the Ti-Particle Mediated Imbalance of OPG/RANKL Via ephrinB2/ephB4 Signaling Pathway and Inhibits the Release of Pro-Inflammatory Factors <i>in vivo</i>
Abstract:Aseptic loosening caused by wear particles is one of the common complications after total hip arthroplasty. We investigated the effect of the recombinant protein ephB4-Fc (erythropoietin-producing human hepatocellular receptor 4) on wear particlemediated inflammatory response. In vitro, ephrinB2 expression was analyzed using siRNA-NFATc1 (nuclear factor of activated T-cells 1) and siRNA-c-Fos. Additionally, we used Tartrate-resistant acid phosphatase (TRAP) staining, bone pit resorption, Enzyme-linked immunoso… Show more
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