An in vivo and in silico analysis of novel variation in TMBIM6 gene affecting cardiopulmonary traits of Indian goats

Swain, Lipi Lekha; Mishra, Chinmoy; Sahoo, Siddhant Sekhar; Nayak, Gangadhar; Pradhan, Sukanta Kumar; Mishra, Smruti Ranjan; Dige, Mahesh Shivanand

doi:10.1016/j.jtherbio.2019.102491

Cited by 4 publications

(1 citation statement)

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“…For some genes, we found additional evidence in species phylogenetically close to cattle. For example, according to Swain and colleagues, variations in TMBIM6 affect the rectal temperature in Indian goats [48], while FKBP11 is a candidate for involvement in seasonal adaptations in reindeer (Rangifer tarandus) [49]. There are several genes that are related to thermoregulation or cold adaptation in non-ungulate species.…”

Section: Discussionmentioning

confidence: 99%

Whole-Genome Resequencing Points to Candidate DNA Loci Affecting Body Temperature under Cold Stress in Siberian Cattle Populations

Igoshin

Yudin

Aitnazarov

et al. 2021

Life

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Despite the economic importance of creating cold resilient cattle breeds, our knowledge of the genetic basis of adaptation to cold environments in cattle is still scarce compared to information on other economically important traits. Herein, using whole-genome resequencing of animals showing contrasting phenotypes on temperature maintenance under acute cold stress combined with the existing SNP (single nucleotide polymorphism) functional annotations, we report chromosomal regions and candidate SNPs controlling body temperature in the Siberian cattle populations. The SNP ranking procedure based on regional FST calculations, functional annotations, and the allele frequency difference between cold-tolerant and cold-sensitive groups of animals pointed to multiple candidate genes. Among these, GRIA4, COX17, MAATS1, UPK1B, IFNGR1, DDX23, PPT1, THBS1, CCL5, ATF1, PLA1A, PRKAG1, and NR1I2 were previously related to thermal adaptations in cattle. Other genes, for example KMT2D and SNRPA1, are known to be related to thermogenesis in mice and cold adaptation in common carp, respectively. This work could be useful for cattle breeding strategies in countries with harsh climates, including the Russian Federation.

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Section: Discussionmentioning

confidence: 99%