An in vitro model for identifying skin-corrosive chemicals. I. Initial validation

Oliver, G.J.A.; Pemberton, Mark; Rhodes, Christopher

doi:10.1016/0887-2333(88)90031-8

Cited by 48 publications

(7 citation statements)

References 14 publications

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“…Several investigations with more than one hundred chemicals have shown good correlations to rabbit dermal tolerance tests. 24,25 In an EEC validation study twelve chemicals have been tested by six laboratories in three in vitro assays, in two alternative human in vivo experiments and in the Draize test with rabbits.26 Results from two cytotoxicity assays were in good agreement with Draize test results concerning the ranking of the test substances. A good non-linear relation was additionally found between results of measurements of lowering of the electric resistance in rat skin slices and measurements of the transepidermal water loss in a human volunteer study.…”

Section: Skin Irritancymentioning

confidence: 57%

The Role of In Vitro Experiments in Animal Welfare

Rasmussen

1993

Hum Exp Toxicol

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Section: Skin Irritancymentioning

confidence: 57%

The Role of In Vitro Experiments in Animal Welfare

Rasmussen

1993

Hum Exp Toxicol

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“…HSEs are used as models for in vitro testing [ 48 ], and can demonstrate fundamental biological processes of the skin such as the examination of different stimuli that lead to the formation of the epidermis [ 49 ], stem cell maintenance [ 50 ], wound healing processes [ 51 ], the effect of corrosiveness of various chemicals on the skin [ 52 ], phototoxicity of substances [ 53 ], and toxicity of various chemicals without the need for animal testing.…”

Section: Tissue Engineered Human Skin Equivalentsmentioning

confidence: 99%

Tissue Engineered Human Skin Equivalents

2012

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Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery) and/or the body (transdermal delivery). In the past three decades, research and development in human skin equivalents have advanced in parallel with those in tissue engineering and regenerative medicine. The human skin equivalents are used commercially as clinical skin substitutes and as models for permeation and toxicity screening. Several academic laboratories have developed their own human skin equivalent models and applied these models for studying skin permeation, corrosivity and irritation, compound toxicity, biochemistry, metabolism and cellular pharmacology. Various aspects of the state of the art of human skin equivalents are reviewed and discussed.

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“…The TER test (18)(19)(20)(21) is based on the observation that TER measurements have been shown to be capable of predicting severe cutaneous effects in vivo. Corrosive materials can be identified by their ability to produce a loss of integrity to the stratum corneum and the barrier function of the skin.…”

Section: The Ter Testmentioning

confidence: 99%

Integrated Decision-tree Testing Strategies for Skin Corrosion and Irritation with Respect to the Requirements of the EU REACH Legislation

et al. 2008

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Liverpool John Moores University and FRAME recently conducted a research project, sponsored by Defra, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evaluation and Authorisation of Chemicals) system for the safety testing and risk assessment of chemicals. The project covered all the main toxicity endpoints associated with the REACH system. This report focuses on how to maximise the use of alternative methods (both in vitro and in silico) for skin corrosion and irritation testing within a tiered testing strategy. It considers the latest developments in in vitro testing, with particular reference to the reconstituted skin models which have now been now been successfully validated and independently endorsed as suitable for both skin corrosivity and irritancy testing within the EU.

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An in vitro model for identifying skin-corrosive chemicals. I. Initial validation

Cited by 48 publications

References 14 publications

The Role of In Vitro Experiments in Animal Welfare

The Role of In Vitro Experiments in Animal Welfare

Tissue Engineered Human Skin Equivalents

Integrated Decision-tree Testing Strategies for Skin Corrosion and Irritation with Respect to the Requirements of the EU REACH Legislation

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