An in vitro / in vivo release test of risedronate drug loaded nano-bioactive glass composite scaffolds

In Situ Hydrogel with Immobilized Mn-Porphyrin for Reactive Oxygen Species Scavenging, Oxygen Generation, and Risedronate Delivery in Bone Defect Treatment

“…With the presence of lysozyme, following an initial burst release on the first day (25–30 μg), risedronate was released in a sustained manner until 6 weeks at a rate of 1–3 μg/day, which falls within a therapeutic window known to aid bone regeneration . The initial burst release would not affect bone regeneration because it would be cleared rapidly from the local site of treatment . In the absence of lysozyme, the release amount was negligible (<1 μg/day) after an initial burst release on the first day for both hydrogels.…”

“…21 The initial burst release would not affect bone regeneration because it would be cleared rapidly from the local site of treatment. 49 In the absence of lysozyme, the release amount was negligible (<1 μg/day) after an initial burst release on the first day for both hydrogels. These results could be explained by the degradation profiles of the hydrogels shown in Figure 3B.…”

Biphasic calcium phosphate doped with zirconia nanoparticles for reconstruction of induced mandibular defects in dogs: cone-beam computed tomographic and histopathologic evaluation

“…The use of animal models is mandatory to validate the bio-functionality, biocompatibility, biodegradability, osteointegrative, osteoconductive as well as osteoinductive properties of bone substitutes before being applied in clinical practice [ 24 , 25 ]. The dog represents an ideal pre-clinical model for studying bone regeneration due to the great similarity between dog’s weight, size, bone density, bone microstructure and turn-over and that of human bone [ 26 – 28 ].…”

Osteogenic potential of calcium silicate-doped iron oxide nanoparticles versus calcium silicate for reconstruction of critical-sized mandibular defects: An experimental study in dog model

“…Pre-clinical experiments are needed to verify biocompatibility, biofunctionality, biodegradability, osteointegration, osteoinduction and osteoconduction characteristics of bone substitutes. The dog is an ideal model for evaluating bone repair and testing bone substitutes ( Taha et al, 2010 , Taha et al, 2018 , Mabrouk et al, 2021 , Mostafa et al, 2021 ). In terms of bone size and weight, trabecular bone density, and bone turn over, the dog's macro- and micro-structure is very comparable to human bone, making it an appropriate model in pre-clinical setting ( Abdel Hamid et al, 2020 , Abdel Hamid et al, 2021 , Mostafa et al, 2021 ).…”