An in vitro determination of antibacterial effect of silver nanoparticles gel as an intracanal medicament in combination with other medicaments against Enterococcus fecalis

Jhamb, Swaty; Singla, Ruchi; Kaur, Amandeep; Sharma, Jyoti; Bhushan, Jagat

doi:10.4103/jcd.jcd_113_20

Cited by 7 publications

(1 citation statement)

References 24 publications

(30 reference statements)

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“…6 These bacteria also have a major role in persistent root canal infections, can survive in the root canals and are resistant to commonly used intracanal dressings. 14 The antibacterial efficacy of CH-iodophors and CH-barium sulfate dressing materials on E. faecalis and P. gingivalis growths were experimentally checked with the agar diffusion method, and inhibition clear zones were measured on the media. Inhibition zone is a laboratory calculation method to check whether a material has the ability to inhibit bacterial growth.…”

Section: Enterococcus Faecalis and Porphyromonas Gingivalismentioning

confidence: 99%

The antibacterial efficacy of calcium hydroxide–iodophors and calcium hydroxide–barium sulfate root canal dressings on Enterococcus faecalis and Porphyromonas gingivalis in vitro

Prasetyo

Juniarti

Sampoerno

et al. 2022

Dent. J. (Majalah Kedokt. Gigi)

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Background: A successful endodontic treatment is inseparable from the right choice of root canal dressing. The right choice of medicaments would result in patient satisfaction. Enterococcus faecalis (E. faecalis) and Porphyromonas gingivalis (P. gingivalis) are usually found in failed root canal treatments. Calcium hydroxide is a gold standard dressing that creates an alkaline environment in the root canal and has a bactericidal effect. Commercially, there are calcium hydroxide dressings with supporting additions, including calcium hydroxide–iodophors (CH–iodophors) and Calcium hydroxide–barium sulfate (CH–barium sulfate). Purpose: This study aimed to compare the antibacterial efficacy between CH–iodophors and CH–barium sulfate root canal dressings on E. faecalis and P. gingivalis. Methods: CH–iodophors and CH–barium sulfate were obtained commercially. E. faecalis and P. gingivalis were obtained from stock culture taken from the root canal of failed endodontic treatment. E. faecalis and P. gingivalis were cultured in Petri dishes, and for each bacterium, 12 wells were made in the media. Six wells were used for the CH–iodophors group, and six wells were used for the CH–barium sulfate group. CH–iodophors and CH–barium sulfate were deployed in the wells in E. faecalis and P. gingivalis cultured media in the Petri dishes. After incubation, the inhibition zone diameters were measured. An independent t-test was used for analysis, and the significance level was set at 5%. Results: There is a significant difference in the antibacterial efficacy of CH–iodophors and that of CH–barium sulfate on E. faecalis and P. gingivalis (p = 0.00001). Conclusion: CH–iodophors have a higher antibacterial efficacy than CH–barium sulfate on both E. faecalis and P. gingivalis.

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Section: Enterococcus Faecalis and Porphyromonas Gingivalismentioning

confidence: 99%

The antibacterial efficacy of calcium hydroxide–iodophors and calcium hydroxide–barium sulfate root canal dressings on Enterococcus faecalis and Porphyromonas gingivalis in vitro

Prasetyo

Juniarti

Sampoerno

et al. 2022

Dent. J. (Majalah Kedokt. Gigi)

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Cross-linked chitosan/lysozyme hydrogels with inherent antibacterial activity and tuneable drug release properties for cutaneous drug administration

Lai

Obireddy

Zhang

et al. 2023

Science and Technology of Advanced Materials

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Gels with high drug release sustainability and intrinsic antibacterial properties are of high practical potential for cutaneous drug administration, particularly for wound care and skin disease treatment. This study reports the generation and characterization of gels formed by 1,5-pentanedial-mediated crosslinking between chitosan and lysozyme for cutaneous drug delivery. Structures of the gels are characterized by using scanning electron microscopy, X-ray diffractometry and Fourier-transform infrared spectroscopy. An increase in the mass percentage of lysozyme leads to an increase in the swelling ratio and erosion susceptibility of the resulting gels. The drug delivery performance of the gels can be changed simply by manipulating the chitosan/lysozyme mass-to-mass ratio, with an increase in the mass percentage of lysozyme leading to a decline in the encapsulation efficiency and drug release sustainability of the gels. Not only do all gels tested in this study show negligible toxicity in NIH/3T3 fibroblasts, they also demonstrate intrinsic antibacterial effects against both Gram-negative and Gram-positive bacteria, with the magnitude of the effect being positively related to the mass percentage of lysozyme. All these warrant the gels to be further developed as intrinsically antibacterial carriers for cutaneous drug administration.

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Silver Nanoparticles as an Intracanal Medicament: A Scoping Review

Kaukab,

Gaur,

Agnihotri

et al. 2023

The Scientific World Journal

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Silver nanoparticles (AgNPs) release Ag ions with potent bactericidal and anti-inflammatory effects. They have shown promising results as an intracanal medicament for removing Enterococcus faecalis (E. faecalis), a resistant bacterium associated with root canal failures. This review summarizes the role of AgNPs as an intracanal medicament. Original research articles on AgNPs as an intracanal medicament were searched in databases such as MEDLINE (PubMed), Scopus, and Embase, resulting in 24 studies. They showed that AgNPs effectively eliminated E. faecalis and reduced postoperative pain following root canal therapy. However, these effects should be further verified through clinical trials as most of the studies were in vitro.

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An in vitro determination of antibacterial effect of silver nanoparticles gel as an intracanal medicament in combination with other medicaments against Enterococcus fecalis

Cited by 7 publications

References 24 publications

The antibacterial efficacy of calcium hydroxide–iodophors and calcium hydroxide–barium sulfate root canal dressings on Enterococcus faecalis and Porphyromonas gingivalis in vitro

The antibacterial efficacy of calcium hydroxide–iodophors and calcium hydroxide–barium sulfate root canal dressings on Enterococcus faecalis and Porphyromonas gingivalis in vitro

Cross-linked chitosan/lysozyme hydrogels with inherent antibacterial activity and tuneable drug release properties for cutaneous drug administration

Silver Nanoparticles as an Intracanal Medicament: A Scoping Review

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