An in vitro biological and anti-bacterial study on a sol–gel derived silver-incorporated bioglass system

Balamurugan, A.; Balossier, G.; Laurent-Maquin, Dominique; Pina, Sandra; Rebelo, Avito; Fauré, J.; Ferreira, J.M.F.

doi:10.1016/j.dental.2008.02.015

Cited by 238 publications

(143 citation statements)

References 30 publications

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“…For instance, one should notice that the bulk silver does not dissolve in water unless there is some counter ions, such as chloride, present in water. However, it is known that nano-silver is soluble in water [25,26]. Therefore, it is plausible that silver was released to water from xerogel made with HNO 3 sol-gel route I since the crystallite size of the silver in this xerogel was *16 nm.…”

Section: Chloride Ion Effect On Antibacterial Activitymentioning

confidence: 99%

Single step sol-gel made silver chloride on Titania xerogels to inhibit E. coli bacteria growth: effect of preparation and chloride ion on bactericidal activity

Tunçer

Şeker

2011

J Sol-Gel Sci Technol

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We report the antibacterial efficacies of silver and/or silver chloride containing titania xerogels synthesized with modified single step sol-gel methods against Escherichia coli bacteria. As the silver loading in TiO 2 increases, the amount of the xerogel required to inhibit the growth of the bacteria decreases and also we found that pure TiO 2 was not bactericidal. Among modified single step sol-gel methods used in this study, the additional HCl treatment sol-gel route III was very effective to obtain only AgCl crystallites in TiO 2 . Based on viable cell count method, 0.125 g/L of 29%Ag/TiO 2 (made with HNO 3 solgel route I) was enough to inhibit the growth of E. coli whereas 0.6 g/L of 29%Ag/TiO 2 (made with the additional HCl treatment sol-gel route III) was required. However, antibacterial activity of 29%Ag/TiO 2 (made with HNO 3 sol-gel route I) after 6 usages was the same as 29%Ag/TiO 2 (made with the additional HCl treatment sol-gel route III).

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Section: Chloride Ion Effect On Antibacterial Activitymentioning

confidence: 99%

Single step sol-gel made silver chloride on Titania xerogels to inhibit E. coli bacteria growth: effect of preparation and chloride ion on bactericidal activity

Tunçer

Şeker

2011

J Sol-Gel Sci Technol

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“…Further studies using 45S5 Bioglass ® particles have shown encouraging results regarding potential angiogenic effects of Bioglass ® , i.e., increased secretion of vascular endothelial growth factor (VEGF) and VEGF gene expression in vitro, as well as enhancement of vascularization in vivo [53][54][55][56] (see §4). In addition, the incorporation of particular ions into the silicate network, such as silver [20][21][22] and boron [26,27], has been investigated in order 6 to develop antibacterial and antimicrobial materials. Bioactive glasses can also serve as vehicle for the local delivery of selected ions being able to control specific cell functions [30,[57][58][59][60][61][62][63][64].…”

Section: Figurementioning

confidence: 99%

“…The high amounts of Na 2 O and CaO, as well as the relatively high CaO/P 2 O 5 ratio make the glass surface highly reactive in physiological environments [11]. Other bioactive glass compositions developed over the years contain no sodium or have additional elements incorporated in the silicate network such as fluorine [13], magnesium [14,15], strontium [16][17][18], iron [19], silver [20][21][22][23], boron [24][25][26][27], potassium [28] or zinc [29,30]. Fabrication techniques for bioactive glasses include both traditional melting methods and sol-gel techniques [1, 3,4,10,[31][32][33], the latter are being highlighted elsewhere [34] and are not covered in this review.…”

Section: Introductionmentioning

confidence: 99%

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Chatzistavrou

2011

Bioactive Glasses

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Traditionally, bioactive glasses have been used to fill and restore bone defects. More recently, this category of biomaterials has become an emerging research field for bone tissue engineering applications. Here, we review and discuss current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for bone tissue engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.

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“…They also noted that at least 95 ppb Ag + ion released in buffered saline was sufficient for 99.9% of reduction against S. aureus after 24 h of incubation. Biological activity of silver-incorporated bioactive glass studies conducted by Balamurugan et al [49] assessed in vitro antibacterial bioactive glass system elicited a rapid bactericidal action. Antimicrobial efficacy of these silver-incorporated bioglass suspension at 1 mg/mL for E. coli was estimated to be >99% killing, and the amount of Ag + released from silver-incorporated glass was up to 0.04 mM after 24 h. In yet another study involving silver ions release by Liu et al [35], the amount of silver released form the mesoporous TiO2 and Ag/TiO2 composites was measured to be 1.6 × 10 −8 mol after 20 days.…”

Section: Quantitative Comparisionsmentioning

confidence: 99%

Antibiofilm Activity of Epoxy/Ag-TiO2 Polymer Nanocomposite Coatings against Staphylococcus Aureus and Escherichia Coli

Santhosh¹,

Natarajan²

2015

Coatings

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Dispersion of functional inorganic nano-fillers like TiO2 within polymer matrix is known to impart excellent photobactericidal activity to the composite. Epoxy resin systems with Ag + ion doped TiO2 can have combination of excellent biocidal characteristics of silver and the photocatalytic properties of TiO2. The inorganic antimicrobial incorporation into an epoxy polymeric matrix was achieved by sonicating laboratory-made nano-scale anatase TiO2 and Ag-TiO2 into the industrial grade epoxy resin. The resulting epoxy composite had ratios of 0.5-2.0 wt% of nano-filler content. The process of dispersion of Ag-TiO2 in the epoxy resin resulted in concomitant in situ synthesis of silver nanoparticles due to photoreduction of Ag + ion. The composite materials were characterized by DSC and SEM. The glass transition temperature (Tg) increased with the incorporation of the nanofillers over the neat polymer. The materials synthesized were coated on glass petri dish. Anti-biofilm property of coated material due to combined release of biocide, and photocatalytic activity under static conditions in petri dish was evaluated against Staphylococcus aureus ATCC6538 and Escherichia coli K-12 under UV irradiation using a crystal violet binding assay. Prepared composite showed significant inhibition of biofilm development in both the organisms. Our studies indicate that the effective dispersion and optimal release of biocidal agents was responsible for anti-biofilm activity of the surface. The reported thermoset coating materials can be used as bactericidal surfaces either in industrial or healthcare settings to reduce the microbial loads. OPEN ACCESSCoatings 2015, 5 96

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An in vitro biological and anti-bacterial study on a sol–gel derived silver-incorporated bioglass system

Cited by 238 publications

References 30 publications

Single step sol-gel made silver chloride on Titania xerogels to inhibit E. coli bacteria growth: effect of preparation and chloride ion on bactericidal activity

Single step sol-gel made silver chloride on Titania xerogels to inhibit E. coli bacteria growth: effect of preparation and chloride ion on bactericidal activity

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Antibiofilm Activity of Epoxy/Ag-TiO2 Polymer Nanocomposite Coatings against Staphylococcus Aureus and Escherichia Coli

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