An improved spectrophotometric method for the determination of salbutamol sulfate with 3-methylbenzthiazolinone-2-hydrazone

Geeta, N.; Baggi, T.R.

doi:10.1016/0026-265x(89)90021-0

Cited by 24 publications

(12 citation statements)

References 8 publications

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“…4b) has been well studied and is characterized by the presence of peaks corresponding to secondary amine salt (C-N) stretch at 1616 and 1509 cm À1 apart from phenolic C-O stretching and secondary alcoholic C-O stretching at 1209 and 1085 cm À1 , respectively. 42,43 After milling, these peaks decreased in intensity as seen in spectra of milled SS (Fig. 4a).…”

Section: Understanding Behind Amorphization Reductionmentioning

confidence: 95%

Influence of excipients in comilling on mitigating milling-induced amorphization or structural disorder of crystalline pharmaceutical actives

Balani

Tan

et al. 2010

Journal of Pharmaceutical Sciences

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Section: Understanding Behind Amorphization Reductionmentioning

confidence: 95%

Influence of excipients in comilling on mitigating milling-induced amorphization or structural disorder of crystalline pharmaceutical actives

Balani

Tan

et al. 2010

Journal of Pharmaceutical Sciences

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“…The most widely used technique for the assay of SBS in pharmaceuticals has been visible spectrophotometry; procedures based on such varied reactions as redox [13,14 ], reduction followed by chelation [15], oxidative coupling [16,17], diazotization and coupling [18,19], nitrosation [20], nitration [21], nitration followed by Meisenheimer complex formation [22], and charge-transfer complex formation [23] are found in literature. However, many of these procedures suffer from one or the other disadvantage (Table 1) such as poor sensitivity, a heating or extraction step, critical working conditions, or the use of organic solvents; and hence are unsatisfactory for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

Three useful bromimetric methods for the determination of salbutamol sulfate

Basavaiah

Prameela

2003

Analytical and Bioanalytical Chemistry

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Three different methods developed for the determination of salbutamol sulfate (SBS), in pure drug form and in dosage forms, are discussed. The methods are based on the oxidation-bromination reaction of the drug by bromine generated in-situ by the interaction of bromate with bromide in acid medium. In titrimetry the drug is titrated directly with bromate in the presence of a large excess of bromide and in sulfuric acid medium using methyl red as indicator. Spectrophotometry is based on addition of a measured excess of bromate-bromide mixture to the sample solution in sulfuric acid medium followed by the estimation of surplus bromine by reacting it with a definite amount of methyl orange dye and measuring the absorbance at 510 nm. The amount of bromate reacting corresponds to the sample content. The kinetic method depends on the linear relationship between the concentration of the drug and time for oxidation and bromination as indicated by the bleaching of the methyl orange acid colour by the bromine generated in situ. Titrimetry is applicable in the 2-20 mg range. In spectrophotometry, Beer's law is obeyed in the 0.5-5.0 microg mL(-1) range whereas concentrations in the 5.0-25.0 microg mL(-1) range can be determined by the kinetic method. The effect of common excipients and additives in tablets is discussed. The procedures have been successfully applied to dosage forms; the results agree well with those obtained by use of a reference method. The methods can be used to determine SBS at mg or nicrog levels.

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“…The most used method for its determination is HPLC with fluorimetric [1,3] or UV [4,5,6] detection. The spectrophotometric determinations based on forming coloured complexes have also been described [7,8,9,10,11,12]. Determinations by flow injection analysis (FIA) with spectrophotometric [13] and chemiluminescence [14] detection have been carried out.…”

Section: Introductionmentioning

confidence: 99%

Determination of salbutamol using on-line solid-phase extraction and sequential injection analysis. Comparison of chemiluminescence and fluorescence detection

et al. 2003

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Determination of salbutamol using sequential injection analysis (SIA) with chemiluminescence and fluorescence detection has been devised. The chemiluminescence signal was emitted during the oxidation of salbutamol by potassium permanganate in sulfuric acid medium. Sodium polyphosphate was used as chemiluminescence enhancer. The fluorescence signal (excitation wavelength 230 nm) was also measured in sulfuric acid medium. Both detection techniques were compared with respect to the application of the methods to the determination of salbutamol in biological materials. The sample pre-treatment takes place directly in the SIA system, when salbutamol is adsorbed on the solid-phase (Baker-carboxylic acid) microcolumn integrated into the system. Sulfuric acid serves both as the reagent and the eluent. The lab-made SIA system consisted of a 2.5-mL Cavro syringe pump, ten-port Vici Valco selection valve and Spectra-Physics FS 970 fluorescence detector, which was lab-modified for chemiluminescence detection. The system was controlled by a PC using originally compiled LabVIEW-supported software. Concentrations, volumes of reagents and flow rates were optimised by a simplex method. Salbutamol was determined in the linear range 0.05-10 microg mL(-1) (RSD 1.53%), with the detection limit (3 sigma) 0.03 microg mL(-1) and sample throughput of 42 samples per hour with chemiluminescence detection in standard solutions. The fluorescence detection enabled the determination of salbutamol in standard solutions in the linear range 0.5-100 microg mL(-1) (RSD 2.69%), with the detection limit 0.2 microg mL(-1) and sample throughput of 24 h(-1). The proposed methods were applied to the determination of salbutamol in human serum and urine. However, serum is a very complicated matrix and the SIA-SPE analysis did not provide satisfactory results. It was possible to determine salbutamol in human urine using this technique. Better recovery was achieved with fluorescence detection.

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An improved spectrophotometric method for the determination of salbutamol sulfate with 3-methylbenzthiazolinone-2-hydrazone

Cited by 24 publications

References 8 publications

Influence of excipients in comilling on mitigating milling-induced amorphization or structural disorder of crystalline pharmaceutical actives

Influence of excipients in comilling on mitigating milling-induced amorphization or structural disorder of crystalline pharmaceutical actives

Three useful bromimetric methods for the determination of salbutamol sulfate

Determination of salbutamol using on-line solid-phase extraction and sequential injection analysis. Comparison of chemiluminescence and fluorescence detection

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