An improved sensitivity non-enzymatic glucose sensor based on a CuO nanowire modified Cu electrode

Abstract

CuO nanowires have been prepared and applied for the fabrication of glucose sensors with highly enhanced sensitivity. Cu(OH)(2) nanowires were initially synthesised by a simple and fast procedure, CuO nanowires were then formed simply by removing the water through heat treatment. The structures and morphologies of Cu(OH)(2) and CuO nanowires were characterised by X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy. The direct electrocatalytic oxidation of glucose in alkaline medium at CuO nanowire modified electrodes has been investigated in detail. Compared to a bare Cu electrode, a substantial decrease in the overvoltage of the glucose oxidation was observed at the CuO nanowire electrodes with oxidation starting at ca. 0.10 V vs. Ag/AgCl (saturated KCl). At an applied potential of 0.33 V, CuO nanowire electrodes produce high and reproducible sensitivity to glucose with 0.49 microA/micromol dm(-3). Linear responses were obtained over a concentration range from 0.40 micromol dm(-3) to 2.0 mmol dm(-3) with a detection limit of 49 nmol dm(-3) (S/N = 3). The CuO nanowire modified electrode allows highly sensitive, low working potential, stable, and fast amperometric sensing of glucose, thus is promising for the future development of non-enzymatic glucose sensors.

Self-assembly of porous copper oxide hierarchical nanostructures for selective determinations of glucose and ascorbic acid

“…17,18 Successful synthesis strategies have been employed to control the morphology of CuO nanostructures as nanowires, hierarchical CuO micro-/nanostructures has been studied for the extension of its sensing applications. 12,19,25 Sun et al, 18a reported the fabrication of hierarchical CuO nanoribbons using a green water/ethanol solution-phase hydrolysis of Cu x (OH) 2xÀ2 (SO 4 ) precursors. Such nanoporous CuO ribbons show a high sensitivity, low detection limit, and a good selectivity towards glucose.…”

A non-enzymatic amperometric sensor for glucose based on cobalt oxide nanoparticles

“…In this regard, the development of electrochemical glucose sensor and biosensor has attracted extensive attention [1][2][3][4][5][6][7][8][9][10][11]. Aiming at the construction of glucose biosensors, glucose oxidase has been widely employed due to its high selectivity and sensitivity to glucose.…”

“…Therefore, considerable attention has been paid to develop non-enzymatic sensors to overcome these problems. Noble metals [5] and metal oxide nanoparticles [2,4,11] have been extensively employed to construct non-enzymatic glucose sensors. However, these sensors suffer from low selectivity, high cost and surface fouling, which greatly limit their practical applications.…”

Nanostructured Inorganic Materials at Work in Electrochemical Sensing and Biofuel Cells

“…High-resolution TEM indicates the nanoporous character of the nanothorn surface with a pore size (diameter) of 2-6 nm, expected to enhance the surface area of the nanothorns. It is worth noting that in an alkaline electrolytic solution, the glucose oxidation occurs in the potential range of 0.40 to 0.8 V vs. Ag|AgCl|KCl sat , where the oxidation wave for Cu(II)/Cu(III) is reported [84][85][86][87]. It was experimentally shown (pH 13.3) that the redox reaction associated with the couple Cu(III)/Cu(II) is a quasi-reversible process with one electron transferred and the determined formal electrode potential is 0.37 V vs. SCE [88,89], that is about 0.41 V vs. Ag|AgCl|KCl sat .…”