A non-enzymatic amperometric sensor for glucose based on cobalt oxide nanoparticles

Abstract

A cobalt oxide nanoparticle-modified glassy carbon (CONM/GC) electrode was prepared by potential cycling in a pH-controlled solution containing tartrate. The electrocatalytic oxidation of glucose on CONM/GC electrode in alkaline solution was investigated and the kinetics was developed. In cyclic voltammograms, the peak current of the oxidation of low valence cobalt oxide in the presence of glucose is increased and it was followed by a decrease in the corresponding cathodic current. This suggested that glucose oxidation was being catalysed on the redox mediator with an electrocatalytic mechanism. Using cyclic voltammetry, chronoamperometry, steady-state polarisation measurements and impedance spectroscopy, the kinetic parameters of the glucose electrooxidation such as charge-transfer coefficient, the catalytic reaction rate constant and the diffusion coefficient were determined. Based on the results, an efficient enzymeless sensing procedure for determination of glucose was developed. The resulting sensor exhibited excellent performance for the glucose determination and a sensitive and time-saving amperometric procedure was successfully applied for the quantification of glucose in both batch and flow systems. Glucose was determined with a linear range of 0.7-60 mM, a limit of detection of 0.15 mM and a sensitivity of 2515.35 mA mM À1 cm À2 in batch system and with a linear range of 1.3-50 mM, a limit of detection of 0.14 mM and a sensitivity of 3240.25 mA mM À1 cm À2 in the flow system.

Nanoporous cobalt oxide nanowires for non-enzymatic electrochemical glucose detection

“…Various cobalt oxides nanostructures [19][20][21][22][23] have been used for non-enzymatic glucose sensors including nanoparticles [19], nanorods [20,22], nanofibers [21,23], and so on. Due to the large surface area provided by 1D nanostructure [24], cobalt oxide nanomaterials with 1D nanostructure for non-enzymatic glucose sensing are actively pursued at present time.…”

A novel synthesis protocol for Co3O4 nanocatalysts and their catalytic applications

“…14 It is a p-type semiconductor, anti-ferromagnetic, highly stable and easy to synthesize in open air atmosphere. Co 3 O 4 -NPs can be synthesized by various methods, such as, electrodeposition, 15 and hydrothermal, 16 solvothermal, 17 polyol, 18 and thermal decomposition. 19 Because of their unusual physical, chemical, magnetic and electronic properties, they have vast applications for use in electrochromic devices, gas sensors, supercapacitors, solar selective absorbers, fuel cells, catalytic applications and lithium ion batteries.…”

Non-enzymatic glucose biosensor based on hyperbranched pine-like gold nanostructure

“…Nanomaterials possess a high real surface area, accelerate the kinetics (of both mass transport and charge transfer processes) of the glucose electrooxidation, and therefore, provide high sensitivity for glucose detection. There have been developed glucose sensors using different nanomaterials including platinum, gold, palladium, and metal oxides [1,[4][5][6]. Among them, due to biocompatibility, higher activity, and lower potential of glucose electrooxidation, gold is one of the most inspiring materials for the fabrication of glucose sensors [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26].…”