An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice

Cherepanov, Stanislav M.; Gerasimenko, Maria; Yuhi, Teruko; Shabalova, Anna A.; Zhu, Hong; Yokoyama, Shigeru; Салмина, А. Б.; Munesue, Shei-ichi; Harashima, Ai; Yamamoto, Yasuhiko; Higashida, Haruhiro

doi:10.1016/j.peptides.2021.170649

Cited by 5 publications

(2 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, the RAGE-dependent OT transport hypothesis has been confirmed by measuring plasma OT concentrations by a simple extraction method called the PPT (acetonitrile protein precipitation) approach ( Cherepanov et al, 2021 ). RAGE KO mice with less soluble forms of RAGE in the plasma displayed larger plasma OT concentration increases after intraperitoneal administration of OT.…”

Section: Discussionmentioning

confidence: 96%

Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

et al. 2022

Self Cite

View full text Add to dashboard Cite

Investigating the neurocircuit and synaptic sites of action of oxytocin (OT) in the brain is critical to the role of OT in social memory and behavior. To the same degree, it is important to understand how OT is transported to the brain from the peripheral circulation. To date, of these, many studies provide evidence that CD38, CD157, and receptor for advanced glycation end-products (RAGE) act as regulators of OT concentrations in the brain and blood. It has been shown that RAGE facilitates the uptake of OT in mother’s milk from the digestive tract to the cell surface of intestinal epithelial cells to the body fluid and subsequently into circulation in male mice. RAGE has been shown to recruit circulatory OT into the brain from blood at the endothelial cell surface of neurovascular units. Therefore, it can be said that extracellular OT concentrations in the brain (hypothalamus) could be determined by the transport of OT by RAGE from the circulation and release of OT from oxytocinergic neurons by CD38 and CD157 in mice. In addition, it has recently been found that gavage application of a precursor of nicotinamide adenine dinucleotide, nicotinamide riboside, for 12 days can increase brain OT in mice. Here, we review the evaluation of the new concept that RAGE is involved in the regulation of OT dynamics at the interface between the brain, blood, and intestine in the living body, mainly by summarizing our recent results due to the limited number of publications on related topics. And we also review other possible routes of OT recruitment to the brain.

show abstract

Section: Discussionmentioning

confidence: 96%

Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…It was also assumed that OT could only be accurately measured after ‘extraction’ [ 80 ]. The dynamic nature of sulfur bonds may allow OT to adhere to other thiol-rich compounds, such as glutathione, making OT both difficult to study and to measure [ 32 , 81 , 82 ]. However, various functions have been described for the linear forms and fragments of OT-like molecules; these may occur when their rings are open or when these molecules are being broken down into fragments (reviewed in [ 3 ]).…”

Section: The Dynamic Nature Of Oxytocinmentioning

confidence: 99%

Oxytocin and oxygen: the evolution of a solution to the ‘stress of life’

Carter

Kingsbury

2022

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

Oxytocin (OT) and the OT receptor occupy essential roles in our current understanding of mammalian evolution, survival, sociality and reproduction. This narrative review examines the hypothesis that many functions attributed to OT can be traced back to conditions on early Earth, including challenges associated with managing life in the presence of oxygen and other basic elements, including sulfur. OT regulates oxidative stress and inflammation especially through effects on the mitochondria. A related nonapeptide, vasopressin, as well as molecules in the hypothalamic–pituitary–adrenal axis, including the corticotropin-releasing hormone family of molecules, have a broad set of functions that interact with OT. Interactions among these molecules have roles in the causes and consequence of social behaviour and the management of threat, fear and stress. Here, we discuss emerging evidence suggesting that unique properties of the OT system allowed vertebrates, and especially mammals, to manage over-reactivity to the ‘side effects’ of oxygen, including inflammation, oxidation and free radicals, while also supporting high levels of sociality and a perception of safety. This article is part of the theme issue ‘Interplays between oxytocin and other neuromodulators in shaping complex social behaviours’.

show abstract

Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation

Parkitny

Carter

Peckins

et al. 2022

Comprehensive Psychoneuroendocrinology

View full text Add to dashboard Cite

An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice

Cited by 5 publications

References 63 publications

Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

Oxytocin and oxygen: the evolution of a solution to the ‘stress of life’

Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation

Contact Info

Product

Resources

About