An Improved Protocol for the Synthesis of Chalcones Containing Pyrazole with Potential Antimicrobial and Antioxidant Activity

Kumari, Simpal; Paliwal, Sarvesh; Chauhan, Renu

doi:10.2174/1573407212666161101152735

Cited by 21 publications

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“…Kumari et al had also constructed chalcones containing a pyrazole moiety and tested them for their antioxidant and antimicrobial activity. The pyrazole–chalcone derivative 119 showed significant activity against B.…”

Section: Biological Activities Of Chalcone Derivativesmentioning

confidence: 99%

Synthesis of Chalcones Derivatives and Their Biological Activities: A Review

et al. 2022

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Chalcone derivatives are considered valuable species because they possess a ketoethylenic moiety, CO–CH=CH–. Due to the presence of a reactive α,β-unsaturated carbonyl group, chalcones and their derivatives possess a wide spectrum of antiproliferative, antifungal, antibacterial, antiviral, antileishmanial, and antimalarial pharmacological properties. Recent developments in heterocyclic chemistry have led to the synthesis of chalcone derivatives, which had been biologically investigated toward certain disease targets. The major aspect of this review is to present the most recent synthesis of chalcones bearing N, O, and/or S heterocycles, revealing their biological potential during the past decade (2010–2021). Based on a review of the literature, many chalcone–heterocycle hybrids appear to exhibit promise as future drug candidates owing to their similar or superior activities compared to those of the standards. Thus, this review may prove to be beneficial for the development and design of new potent therapeutic drugs based on previously developed strategies.

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Section: Biological Activities Of Chalcone Derivativesmentioning

confidence: 99%

Synthesis of Chalcones Derivatives and Their Biological Activities: A Review

et al. 2022

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“…After 10 min of incubation at room temperature, the absorbance at 546 nm was measured three times. [26][27] Scavenging effect (%) = (Control−sample O.D./control O.D.)×100. The statistical analysis was performed using GraphPad Prism 5.…”

Section: Nitric Oxide Scavenging Activitymentioning

confidence: 99%

Saccharomyces cerevisiae Catalyzed Synthesis and Evaluation of Pyrazoles

Rajkumar¹,

Venkata²,

Nagarajan³

2022

Ind. J. Pharm. Edu. Res

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Background: Biocatalysis in organic solvents has several benefits over aqueous solvents, including solubility of organic substrates, ease of workup, separation of the product, and, in certain cases, reusability of biocatalysts. Materials and Methods: A simple, effective, and environmentally friendly technique for synthesizing pyrazoles has been established, which involves the cyclo condensation of chalcones and isonicotinic acid hydrazide in organic solvents using a relatively inexpensive catalyst baker's yeast (Saccharomyces cerevisiae). Molecular properties prediction and docking studies were also performed. Results:The predicted molecular properties suggest that the molecules are safe for oral consumption and their docking studies on 2BVC-Mycobacterium tuberculosis glutamine synthetase show their favorable ligand binding nature. The structural assignments were validated based on spectrum data. The compounds were evaluated for their antitubercular, in vitro anti-inflammatory, and anti-oxidant effects. The analysis reveals that synthesized derivatives of pyrazoles possessing methoxy, nitro, hydroxyl, fluoro, and chloro substitution through the phenyl ring help the molecule to increase its pharmacological activities. However, the substituted thiophene ring in the side chain also facilitates the biological action of the molecules. Conclusion: Anti-inflammatory, anti-oxidant, and anti-tubercular properties are due to the presence of the pyrazole ring.

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“…Chalcones were reported with significant antioxidant activity [17][18] and some of their biological profiles are due to their antioxidant effect [19]. Many reports had clearly revealed that the heteroaryl chalcones comprise excellent antioxidant potential and these compounds are good starting points for the successful development of new drug candidates [20][21][22][23][24][25]. Chalcones display antioxidant action either by scavenging the highly reactive free radicals or the reactive oxygen species (ROS) or by antagonizing the enzyme aldose reductase [26].…”

Section: Short Research Articlementioning

confidence: 99%

Antioxidant Studies of Thiazole Ring Bearing Chalcone Derivatives

Kasetti

Dwivedi

Nagasuri³

2021

JPRI

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Oxidative stress is one of the common problems seen in a variety of diseases. Chalcones and in particular heteroaryl chalcones had reported with promising antioxidant activities. Hence, in the present work, we reported the antioxidant activity of twenty thiazole ring bearing chalcone derivatives (1-20). Among the tested compounds, compounds 17, 19 and 20 containing 2-pyridinyl, 3-pyridinyl and 2-thiazolyl scaffolds showed superior antioxidant activity than the standard with their IC50 values 4±1µg/mL, 3±1 µg/mL and 5±1 µg/mL respectively. The compound 19 is an interesting lead for the development of newer antioxidant agents.

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An Improved Protocol for the Synthesis of Chalcones Containing Pyrazole with Potential Antimicrobial and Antioxidant Activity

Cited by 21 publications

References 0 publications

Synthesis of Chalcones Derivatives and Their Biological Activities: A Review

Synthesis of Chalcones Derivatives and Their Biological Activities: A Review

Saccharomyces cerevisiae Catalyzed Synthesis and Evaluation of Pyrazoles

Antioxidant Studies of Thiazole Ring Bearing Chalcone Derivatives

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