An Improved Procedure for the Gas Chromatography–Tandem Mass Spectrometry Detection of the Globin Adduct of Sulfur Mustard

Fluoride derivatization-enabled sensitive and simultaneous detection of biomarkers for nitrogen mustard in human plasma and urine via gas chromatography tandem mass spectrometry

“…Gas chromatographymass spectrometry/mass spectrometry (GC-MS/MS), which has a better separation ability, was used to investigate the biomarkers of SMs or NMs in plasma and urine samples. [25][26][27][28] However, due to the polarity and volatility of the alcohol amines, additional derivatization was unavoidable. The purpose of the derivatization was to derive the alcohol amines into nonpolar compounds, such as corresponding trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBDMS) esters.…”