Fluoride derivatization-enabled sensitive and simultaneous detection of biomarkers for nitrogen mustard in human plasma and urine <i>via</i> gas chromatography tandem mass spectrometry

Yang, Fang-chao; Yang, Yang; Yan, Long; Wang, Feng-yun; Wu, Lei; Xia, Ming-zhu; Li, Xiao-Sen

doi:10.1039/d3ra04697d

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…Selected ions were applied as m/z = 169 and m/z = 241 for both MDEA and TEA derivatives, and m/z = 298 and m/z = 169 for EDEA derivatives. The column and instrumental conditions for GC-MS-CI/SRM analysis remained consistent with previously reported parameters [4].…”

Section: Instrument Conditionssupporting

confidence: 76%

“…The content of EAs in the solution was determined by GC-MS [ 4 ]. The adsorption kinetics for the different targets reflected the rate at which adsorption reached equilibrium.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to SMs, which have been fully investigated, NMs such as bis(2-chloroethyl)ethylamine (HN1), bis(2-chloroethyl)methylamine (HN2), and tris(2-chloroethyl)amine (HN3) have attracted increasing attention in the last few years. Notably, NMs are facile to synthesize, stable, and challenging to counteract [ 3 , 4 ]. The toxicity of NMs primarily destroys the skin, eyes, and respiratory tract.…”

Section: Introductionmentioning

confidence: 99%

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Highly Efficient Separation of Ethanol Amines and Cyanides via Ionic Magnetic Mesoporous Nanomaterials

Zhao,

Yang,

et al. 2024

IJMS

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Simple and efficient sample pretreatment methods are important for analysis and detection of chemical warfare agents (CWAs) in environmental and biological samples. Despite many commercial materials or reagents that have been already applied in sample preparation, such as SPE columns, few materials with specificity have been utilized for purification or enrichment. In this study, ionic magnetic mesoporous nanomaterials such as poly(4-VB)@M-MSNs (magnetic mesoporous silicon nanoparticles modified by 4-vinyl benzene sulfonic acid) and Co2+@M-MSNs (magnetic mesoporous silicon nanoparticles modified by cobalt ions) with high absorptivity for ethanol amines (EAs, nitrogen mustard degradation products) and cyanide were successfully synthesized. The special nanomaterials were obtained by modification of magnetic mesoporous particles prepared based on co-precipitation using -SO3H and Co2+. The materials were fully characterized in terms of their composition and structure. The results indicated that poly(4-VB)@M-MSNs or Co2+@M-MSNs had an unambiguous core-shell structure with a BET of 341.7 m2·g−1 and a saturation magnetization intensity of 60.66 emu·g−1 which indicated the good thermal stability. Poly(4-VB)@M-MSNs showed selective adsorption for EAs while the Co2+@M-MSNs were for cyanide, respectively. The adsorption capacity quickly reached the adsorption equilibrium within the 90 s. The saturated adsorption amounts were MDEA = 35.83 mg·g−1, EDEA = 35.00 mg·g−1, TEA = 17.90 mg·g−1 and CN−= 31.48 mg·g−1, respectively. Meanwhile, the adsorption capacities could be maintained at 50–70% after three adsorption–desorption cycles. The adsorption isotherms were confirmed as the Langmuir equation and the Freundlich equation, respectively, and the adsorption mechanism was determined by DFT calculation. The adsorbents were applied for enrichment of targets in actual samples, which showed great potential for the verification of chemical weapons and the destruction of toxic chemicals.

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Section: Instrument Conditionssupporting

confidence: 76%

“…The content of EAs in the solution was determined by GC-MS [ 4 ]. The adsorption kinetics for the different targets reflected the rate at which adsorption reached equilibrium.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Highly Efficient Separation of Ethanol Amines and Cyanides via Ionic Magnetic Mesoporous Nanomaterials

Zhao,

Yang,

et al. 2024

IJMS

Self Cite

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Development an automated and high -throughput analysis methods for detecting 64 anabolic androgenic steroids in urine using gas chromatography-mass spectrometry

Wu,

Ma,

Xing

et al. 2024

Talanta Open

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Fluoride derivatization-enabled sensitive and simultaneous detection of biomarkers for nitrogen mustard in human plasma and urine via gas chromatography tandem mass spectrometry

Abstract: Methyl-diethanolamine (CAS: 105-59-9), ethyl-diethanolamine (CAS: 139-87-7), and triethanolamine (CAS: 102-71-6) were identified as the degradation products and bio-markers of nitrogen mustard exposure.

Cited by 2 publications

References 26 publications

Highly Efficient Separation of Ethanol Amines and Cyanides via Ionic Magnetic Mesoporous Nanomaterials

Highly Efficient Separation of Ethanol Amines and Cyanides via Ionic Magnetic Mesoporous Nanomaterials

Development an automated and high -throughput analysis methods for detecting 64 anabolic androgenic steroids in urine using gas chromatography-mass spectrometry

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