An improved method of preparation of potassium cyanide‐¹⁴C

Abstract

SUMMARYA safe procedure for the conversion of barium carbonate-I4C to potassium cyanide-I4C on a 6-7 mmol scale in 90-98% yield was developed. Barium carbonate-14C was heated with excess potassium azide in a matrix of sand without added potassium metal, allowing safe, rapid and convenient recovery of the cyanide.

Synthesis of 2 carbon‐14 analogue of thioflavanones

“…Barium 14 C‐carbonate 235.9 MBq/mmol was purchased from Amersham Pharmacia Biotech UK Ltd. (Amersham Place, Little Chalfont, Buckinghamshire, England) and was converted to potassium [ 14 C]cyanide according to the standard procedure . Moreover, potassium [ 14 C]cyanide was converted to [carboxyl‐ 14 C]thiosalicylic acid according to the method previously used in multistep .…”

Synthesis of carbon‐14 analogue of N‐(1‐methyl‐2‐oxo‐5‐phenyl‐2,3‐dihydro‐1H‐benzo[e][1,4]diazepin‐3‐yl)‐benzamide‐[carboxyl‐14C] as CCK‐A antagonist

“…13 IR spectra were recorded on a Bruker FT-IR, Vector 22 instrument and the 1 H-NMR spectra were recorded on a Varian unity plus 400 spectrometer (400 MHz). Radioactivity was determined using a Beckman LS6500 liquid scintillation spectrometer.…”

Absorption and disposition of14C-labelled oxiracetam in rat, dog and man

“…Potassiwn [14C]-cyanide (K 14CN; I) was prepared according to the method of Peny et al (9): bariwn [14C]-carbonate (6.73 GBq; Medipro AG, Teufen, Switzerland) was reacted with potassiwn nitride (KN3) yielding potassiwn [14C]-cyanide (I) (6.07 GBq; 90%).…”