An improved echo-tracker for studies on pulse waves in the fetal aorta

Lindström, Kjell; Gennser, G.; Eriksen, Poul Sindberg; Benthin, M; Dahl, Philip

doi:10.1016/b978-0-407-00450-4.50033-2

Cited by 38 publications

(46 citation statements)

References 14 publications

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“…Ultrasonographic measurements were performed using a phase-locked echo-tracking system (Diamove ® , Teltec AB, Lund, Sweden) with a spatial resolution of less than 10 µm 14,15 . The time resolution was 1.15 ms and the smallest detectable movement was 8 µm 14 .…”

Section: Methodsmentioning

confidence: 99%

“…The time resolution was 1.15 ms and the smallest detectable movement was 8 µm 14 . Briefly, the echo-tracking instrument consist of a 3.5 MHz linear array transducer interfaced with a real time ultrasound scanner (EUB 240; Hitachi, Tokyo, Japan) 15 . Two electronic markers automatically identify the posterior and anterior arterial wall respectively and follow its pulsatile movements.…”

Section: Methodsmentioning

confidence: 99%

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Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

2014

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Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Link to publication Citation for published version (APA): Gottsäter, M., Länne, T., & Nilsson, P. M. (2014). Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Journal of Human Hypertension, 28(7), 456-460. DOI: 10.1038456-460. DOI: 10. /jhh.2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractArterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment -insulin resistance (HOMA-IR), lipids and abdominal obesity.This study includes 335 subjects from Malmö, Sweden, examined in 1991 and again at follow-up in 1998-2000. Ultrasound measurement of the abdominal aorta was performed at follow-up investigation.In the female subgroup, there was a positive association between HOMA-IR at baseline and abdominal aortic stiffness at follow-up (beta=0.18, p=0.03) and a negative association between high density lipoprotein and aortic stiffness (beta=-0.23, p=0.005), independently of classical cardiovascular risk factors. These associations were not found among men. The results suggest a greater or different role of impaired glucose metabolism in the pathophysiology of arterial stiffness in women than in men.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

2014

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“…The methodological details have been described elsewhere. 19 Briefly, a high-fidelity system comprising a real-time B-mode ultrasonic scanner (Hitachi EUB 240), 2 pairs of electronic echo-trackers ([TM]Diamove[/TM], Teltec), and a desktop computer was used to detect and measure the pulsatile movements of the vessel walls. From these waveforms, the following variables were measured: the end-diastolic diameter (mm), the pulse amplitude of the diameter (mm), and the maximum incremental velocity of the diameter during the systolic phase (MIV, mm/s).…”

Section: Perfusion Units Of Output Voltage (1 Perfusion Unit [Pu]ϭ10 mentioning

confidence: 99%

Impaired Endothelial Function and Increased Carotid Stiffness in 9-Year-Old Children With Low Birthweight

et al. 2000

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Background-Low birthweight (LBW) has been associated with an increased incidence of adult cardiovascular disease.Endothelial dysfunction and loss of arterial elasticity are early markers of hypertension and atherosclerosis. We studied the prevalence of these markers in 44 healthy, prepubertal (age 9Ϯ1.3 years) children, 22 with LBW for age. Methods and Results-Endothelial function in skin was tested with the local application of acetylcholine (inducing endothelium-dependent vasodilation) and nitroglycerin (endothelium-independent vasodilation), and local perfusion changes were measured with the laser Doppler method. The elastic properties of the abdominal aorta and common carotid artery were measured with an ultrasonic vessel-wall tracking system. Endothelium-dependent vasodilation was lower in children with LBW (88Ϯ33 perfusion units [PU]) than in normal-birthweight controls (133Ϯ34 PU, PϽ0.001).There was no difference in aortic or carotid elasticity between the 2 groups, but a negative correlation was found between birthweight and stiffness of the carotid artery wall (rϭϪ0.45, PϽ0.01). Endothelium-independent vasodilation and blood pressure were similar in the 2 groups. Conclusions-Schoolchildren with a history of LBW show impaired endothelial function and a trend toward increased carotid stiffness. These findings may be early expressions of vascular compromise, contributing to susceptibility to disease in adult life.

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“…Developmental changes in the behaviour of the arterial wall of the fetus have been described following a series of animal experiments and observations of the human fetus using a wall-tracking device developed by the team of Professor Karel Marsál in the University of Lund, Sweden (Gustafsson et al, 1989;Lindström et al, 1987;Sonesson et al, 1993). These studies have described changes in the biophysical properties of the aorta of the human fetus during normal development and associated with growth restriction (Stale & Gennser, 1991;Gardiner et al, 1998).…”

Section: Developmental Physiology Of the Vessel Wallmentioning

confidence: 99%

Early Changes in Vascular Dynamics in Relation to Twin-Twin Transfusion Syndrome

Gardiner¹

2001

Twin res.

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Aclearer understanding of the early determinants of normal and abnormal vascular development is pivotal in order to identify those at increased risk of later vascular disease, and perhaps to prevent it by early intervention. Measurement of pulse wave velocity(PWV) has been used in the postnatal evaluation of the monochorionic(MC) twins. They are genetically identical and those with twin-twin transfusion syndrome(TTTS) provide an ideal natural model in whom to study the influence of differing haemodynamic stresses on the developing vascular tree. We investigated firstly whether surviving twin pairs with TTTS have altered arterial distensibility in childhood by comparing PWV in the radial arteries of surviving MC twin pairs with TTTS and in two control groups, one cohort of MC twins without TTTS and another dichorionic group (DC) Secondly, we tested a cohort of TTTS twin pair survivors treated with laser photocoagulation. The co-twin pairs in the group managed palliatively with amnioreduction showed increased PWV in the donor and reduced PWV in the recipient twins. This was neither seen in the laser-treated, nor in the control groups. Our studies suggest that a period of haemodynamic imbalance gives rise to changes in a muscular conduit artery that persist at least into infancy and it seems that by correcting the abnormal haemodynamics relatively soon after the disease process had begun, the alterations in elasticity are prevented. These studies are the first to demonstrate fetal programming of the vascular bed in humans, and prevention or reversal of this programming by an intervention in mid-gestation.

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An improved echo-tracker for studies on pulse waves in the fetal aorta

Cited by 38 publications

References 14 publications

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Impaired Endothelial Function and Increased Carotid Stiffness in 9-Year-Old Children With Low Birthweight

Early Changes in Vascular Dynamics in Relation to Twin-Twin Transfusion Syndrome

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