Investigations into creep-fatigue life and the corresponding failure physical mechanism are crucial for guaranteeing the structural integrity of components.In this work, a series of strain-controlled fatigue and creep-fatigue tests were performed at different temperatures. Then, the EBSD-TEM combinative analysis was performed to reveal the microstructure evolution. The creep failure parameter dependence derived from standard creep experimental data and their importance in further creep-fatigue employment were discussed. Resultsshow that strain energy density has better relevance than ductility in connecting with creep failure. The temperature-dependent critical strain energy density and an equivalent failure strain energy density, considering geometric effect, were incorporated with the current energy-based model, which enables creep-fatigue life scatter within a factor of 1.5. Moreover, multi-slip activations and severe slip interactions under creep-fatigue conditions were responsible for the ultimately lifetime reductions based on microstructure observations.