An improved and one-pot procedure to the synthesis of symmetric amines by domino reactions of 5-methyl-1,3,4-thiadiazole-2-amine, a new nitrogen atom donor, and alkyl halides

Symmetrical Tertiary Amines: Applications and Synthetic Approaches

“…In 2017 Soleiman‐Beigi and co‐authors developed a protocol for the trialkylamines synthesis from 5‐methyl‐1,3,4‐thiadiazole‐2‐amine as a nitrogen source. [ 93 ] This nitrogen‐precursor is easy to handle alternative for ammonia which allows tuning the reaction outcome (primary, secondary or tertiary amines) by varying the base strength and starting molecules ratio. This protocol leads to high yields and does not require any catalysts.…”

Direct synthesis of cyclohexylamine from cyclohexene and NH3 over ZSM-5 catalysts: Impact of mesoporosity and acidity

“…In addition, cyclohexylamine can also be obtained from chlorocyclohexane, which is derived from cyclohexane by chlorination. 10 Thus, in view of green and sustainable chemistry, the development of new methodologies for direct amination of cyclohexene to produce cyclohexylamine with 100% atom efficiency is considered to be a promising single-step process utilizing easily accessible feedbacks of cyclohexene and ammonia, offering environmental benefit to the future industrial production.…”

Insights into structure–function relationships of mesoporous H-ZSM-5 zeolite catalysts for direct amination of cyclohexene with NH3

“…In addition, cyclohexylamine can also be obtained from chlorocyclohexane, which is derived from cyclohexane by chlorination. 10 Thus, in view of green and sustainable chemistry, the development of new methodologies for direct cyclohexene amination to prepare cyclohexylamine with 100% atom efficiency is considered to be a promising single-step process utilizing easily accessible feedstocks of NH 3 or cyclohexene, affording environmental benefits towards future industrial production.…”