An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload

Addison, G. M.; Beamish, M. R.; Hales, Crispin; Hodgkins, Michael; Jacobs, A.; Llewellin, P.

doi:10.1136/jcp.25.4.326

Cited by 551 publications

(181 citation statements)

References 5 publications

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“…Serum ferritin is directly proportional to body iron stores and concentration <12 ng/ml reflects an iron-depleted state. [9][10][11][12][13] The aim of this study was to evaluate the frequency of iron deficiency in Santa Casa Hemocenter blood donors and to establish the frequency of iron deficiency in blood donors according to sex, whether they were first-time or multi-time donors, and the blood donation frequency per year.…”

Section: Introductionmentioning

confidence: 99%

Iron deficiency in blood donors

Cançado¹,

Chiattone²,

Alonso³

et al. 2001

Sao Paulo Med. J.

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CONTEXT: Blood donation results in a substantial loss of iron (200 to 250 mg) at each bleeding procedure (425 to 475 ml) and subsequent mobilization of iron from body stores. Recent reports have shown that body iron reserves generally are small and iron depletion is more frequent in blood donors than in non-donors. OBJECTIVE: The aim of this study was to evaluate the frequency of iron deficiency in blood donors and to establish the frequency of iron deficiency in blood donors according to sex, whether they were first-time or multi-time donors, and the frequency of donations per year. DESIGN: From September 20 to October 5, 1999, three hundred blood donors from Santa Casa Hemocenter of São Paulo were studied. DIAGNOSTIC TESTS: Using a combination of biochemical measurements of iron status: serum iron, total iron-binding capacity, transferrin saturation index, serum ferritin and the erythrocyte indices. RESULTS: The frequency of iron deficiency in blood donors was 11.0%, of whom 5.5% (13/237) were male and 31.7% (20/63) female donors. The frequency of iron deficiency was higher in multi-time blood donors than in first-time blood donors, for male blood donors (7.6% versus 0.0%, P < 0.05) and female ones (41.5% versus 18.5%, P < 0.05). The frequency of iron deficiency found was higher among the male blood donors with three or more donations per year (P < 0.05) and among the female blood donors with two or more donations per year (P < 0.05). CONCLUSIONS: We conclude that blood donation is a very important factor for iron deficiency in blood donors, particularly in multi-time donors and especially in female donors. The high frequency of blood donors with iron deficiency found in this study suggests a need for a more accurate laboratory trial, as hemoglobin or hematocrit measurement alone is not sufficient for detecting and excluding blood donors with iron deficiency without anemia.

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Section: Introductionmentioning

confidence: 99%

Iron deficiency in blood donors

Cançado¹,

Chiattone²,

Alonso³

et al. 2001

Sao Paulo Med. J.

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“…Formulas have been devised to estimate iron stores from concentrations of serum ferritin in healthy individuals (Cook & Finch, 1979;Cook et al, 1986). The introduction of serum ferritin for the evaluation of the iron status (Addison et al, 1972;Jacobs et al, 1972) was a marked diagnostic improvement since low serum ferritin concentrations are only seen in iron de®ciency, indicating an absence of iron stores. Low serum ferritin is not associated with any other known condition (Walters et al, 1973).…”

Section: Introductionmentioning

confidence: 99%

Effect of a mild infection on serum ferritin concentration—clinical and epidemiological implications

Hulthén

Lindstedt

et al. 1998

Eur J Clin Nutr

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Objectives: To study the distribution of serum ferritin concentration in adolescent boys and girls with and without a preceding mild infection. Design: The prevalence of iron de®ciency was studied in two representative samples. The ®rst sample from 1990 comprised 207 boys and 220 girls. The second sample from 1994 included 620 boys and 624 girls. In total 1675 adolescents, 15±16 y old, 827 boys and 844 girls were studied. Results: A signi®cant shift of serum ferritin concentration towards higher values was observed in those who reported an upper respiratory infection with fever during the preceding month (P`0.001). Signi®cant differences were found between serum ferritin values in healthy, not infected adolescents and serum ferritin values in those with ongoing infection, both in boys and girls in the two materials (P`0.01), and in those with a mild infection during the preceding three weeks. Conclusions:The prevalence of recent infection should be included as information when trying to assess the prevalence of iron de®ciency on the basis of serum ferritin measurements and when examining relationships between iron status and composition of the diet. The ®ndings imply that differences in prevalence of iron de®ciency between different studies might partly be explained by differences in prevalence of simple respiratory infections. The diagnostic sensitivity of the serum ferritin assay for iron de®ciency, using conventional reference limits, decreases for subjects with recent such infections; similarly, there will be a decrease in the diagnostic speci®city for haemochromatosis. Sponsorship: Swedish Medical Research Council (project B9519X-04721-20B) and Swedish Dairy Association, Stockholm. Descriptors: serum ferritin concentration; mild infection; adolescents; prevalence of iron de®ciency; diagnostic sensitivity and speci®cityairon de®ciency; iron overload

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“…Eleven healthy Brazilian individuals, living in non-endemic areas of Pernambuco, with negative stool examinations and no previous history of exposure to schistosoma infection were included as controls. Total IgE (E immunoglobulin) antibodies were measured in plasma by the ACCESS (Beckman Coulter) immunoassay, as described elsewhere (Addison et al 1972). Differences between paired groups were assessed by the Wilcoxon signed rank test and correlation between variables was determined by calculating the Spearman's rank correlation coefficients.…”

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confidence: 99%