Iron deficiency in blood donors

Cançado, Rodolfo Delfini; Chiattone, Carlos S.; Alonso, Felipe; Junior, Durão; Alves, Rita de Cássia Marques

doi:10.1590/s1516-31802001000400003

Cited by 51 publications

(79 citation statements)

References 11 publications

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“…Cancado et al [8] found that the frequency of iron deficiency was higher among male donors with three or more donations per year and among the women with two or more donations per year. The results of all these studies were similar to our findings and showed the importance of measuring iron stores as an indicator for being selected for blood donation.…”

Section: Resultsmentioning

confidence: 99%

Iron Balance in Regular Blood Donors

Mozaheb

Khayami

Sayadpoor

2011

Transfus Med Hemother

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Background: Numerous reports have shown that iron stores decrease in blood donors after donation. As we need healthy donors, it is essential to test hemoglobin and ferritin levels for preventing reduced of iron stores in donors. Methods: This study was conducted on 235 healthy men. The donors were divided into three groups: group I) control group with no donation; group II) case group 1 with two donations within 1 year; group III) case group 2 with three donations within 1 year. Results: The mean level of hemoglobin was 15.9 and 14.7 g/dl in the control group and in the case group, respectively (p < 0.0000). The mean level of serum ferritin in group I, II and III, was 108, 56 and 26 mg/l, respectively (p < 0.0000). When studying various stages of iron deficiency in donors, it could be shown that 58% of group III donors but only 1% of control group donors had a negative iron balance. Moreover, iron deficiency anemia was observed in 20% of group III donors. Conclusion: Just measuring the hemoglobin level is not sufficient for selecting donors. In addition, testing of the ferritin level and iron supplementation are recommended in regular donors with more than one donation per year.

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Section: Resultsmentioning

confidence: 99%

Iron Balance in Regular Blood Donors

Mozaheb

Khayami

Sayadpoor

2011

Transfus Med Hemother

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“…5 Indeed, blood donation can result in reduction of body iron stores. 7,17 Considering that iron deficiency has been defined as SF concentrations < 12 ng/ml, 16 no one in this study had iron deficiency according to SF levels. Although iron intake in the current study was lower than the Dietary Reference Intake (DRI) (around 7 mg/day rather than the recommended 8 mg/day), the subjects' diet was composed of low to moderate amounts of iron absorption inhibitory factors, high quantities of iron absorption enhancers and foods with highly bioavailable iron.…”

Section: Discussionmentioning

confidence: 99%

Relationship between blood donors' iron status and their age, body mass index and donation frequency

et al. 2013

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CONTEXT AND OBJECTIVE: Regular blood donation may decrease body iron storage and lead to anemia. The aim here was to evaluate the iron status of Iranian male blood donors and the impact of age, body mass index (BMI) and donation frequency over one year, on iron status indices. DESIGN AND SETTING: Cross-sectional, descriptive and analytical study at Tehran Blood Transfusion Center, Tehran, Iran. METHODS: Between July and September 2011, 117 male blood donors were selected and divided into four groups according to their frequency of blood donation. Thirty male non-donors were also recruited as controls after adjusting for age, weight, height, smoking habits and monthly income. Iron status indices and some criteria such as general health and dietary measurements were determined among all subjects. RESULTS:The values of the iron-related parameters were significantly lower among donors than among non-donors. Only total iron binding capacity (TIBC) was found to be significantly higher among different donor groups than in the controls. A significant positive correlation was observed between age and serum ferritin (SF) only among the donors who had donated once within the preceding year. The iron status indices did not show any significant relationship with BMI among donors or non-donors. CONCLUSION: A donation frequency of more than twice a year had a significant influence on iron-related parameters. Therefore, without annual measurement of these parameters, further phlebotomies may lead to iron deficiency and donor rejection in the future. RESUMO

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“…13 It is further important to mention that to replenish the iron store even in mild degree of anaemia needs the dietary care and specific treatment for at least three months, even if the Hb level is being corrected much earlier. 1,3,5,[14][15][16][17][18][19][20] The lower the SF level, higher will be the possibility to suffer from anaemia i.e., potentially anaemic. Prevention of iron deficiency is essential as it is well known that anaemia causes non-specific symptoms like tiredness, weakness, headache, breathlessness, irritability, including the decreased work capacity.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Blood donation results in a substantial (200-250mg) loss of iron at each bleeding procedure (425-475ml) and therefore, the frequency of blood donation is so adjusted as to prevent anaemia in most donors. 3 However, the effect of blood donation on the status of total body iron content is often neglected, despite the fact that body iron reserve is small and therefore, iron depletion is better to be considered at least in blood donors and especially in repeat donors. 4,5 In the majority of blood banks, haemoglobin and/or haematocrit measurements are used as routine screening tests for allowing a person to donate blood.…”

Section: Introductionmentioning

confidence: 99%