An immunological model connecting the pathogenesis of stress, depression and carcinoma

Holden, R.J.; Pakula, I.S.; Mooney, Phyllis

doi:10.1016/s0306-9877(98)90054-8

Cited by 53 publications

(29 citation statements)

References 46 publications

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“…This corroborates well with the findings of Choi et al [25]. The cytokine profile (IL-2 and IFN-Á) of these cell populations from the two groups of individuals is also in line with the observation of Holden et al [26] (table 1) who showed decreased …”

Section: T Cell Subpopulations and Their Cytokine Profilessupporting

confidence: 92%

Physiological Concentrations of Dopamine Inhibit the Proliferation and Cytotoxicity of Human CD4+ and CD8+ T Cells in vitro: A Receptor-Mediated Mechanism

Saha

Mondal

Majumder

et al. 2001

Neuroimmunomodulation

101

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Objective: Dopamine, a catecholamine neurotransmitter, influences growth and proliferation of lymphocytes. Pharmacological doses of dopamine have been shown to modulate T cell functions significantly, but no information is available on the effect of physiological concentrations of circulating dopamine on CD4+ and CD8+ T cell functions. This information may be of importance since significantly elevated plasma dopamine levels were observed in humans during uncoping stress, and suppression of T cell functions during stress is a well-known phenomenon. However, the mechanism inducing the suppression of T cell functions during stress is not yet clear. In the present investigation, we evaluated the effect of the dopamine level attained in the plasma of individuals with uncoping stress on the proliferation and cytotoxicity of CD4+ and CD8+ T cells in vitro. Methods: T cell subpopulations were separated by panning. The effect of dopamine on IL-2-induced cell proliferation in vitro was evaluated by [³H]thymidine incorporation and cytotoxicity by ⁵¹Cr release, receptors by radioligand binding, cAMP by an assay kit and apoptosis by DNA fragmentation. Results: At these elevated physiological concentrations, dopamine was found to inhibit significantly the proliferation and cytotoxicity of CD4+ and CD8+ T cells in vitro. This dopamine-mediated inhibition of proliferation was more marked on CD8+ T cells than on CD4+ T cells. The underlying mechanism was found to be D1 class of dopamine-receptor-mediated stimulation of intracellular cAMP. Conclusion: Results may be of significance to understand the role of peripheral dopamine in human neuroimmune communication in terms of physiological homeostasis in health and disease.

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Section: T Cell Subpopulations and Their Cytokine Profilessupporting

confidence: 92%

Physiological Concentrations of Dopamine Inhibit the Proliferation and Cytotoxicity of Human CD4+ and CD8+ T Cells in vitro: A Receptor-Mediated Mechanism

Saha

Mondal

Majumder

et al. 2001

Neuroimmunomodulation

101

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“…Thus, effective treatment of depression results in better patient adjustment, reduced symptoms, reduced cost of care and may influence disease course. 39 A combined evaluation and treatment approach where the urologist and psychotherapist or psychiatrist work out an effective treatment plan considering psychological and urological perspectives on the etiology of depression is best for the patient.…”

Section: Depression and Prostate Cancermentioning

confidence: 99%

Psychological aspects of prostate cancer: a clinical review

Sousa

Sonavane

Mehta

2012

Prostate Cancer Prostatic Dis

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Prostate cancer is the most common non-skin cancer in men. It is fraught with both physical and psychological symptomatology. Depression, anxiety, stress, fatigue, pain and psychosocial factors all affect the patient with prostate cancer. Impotence, erectile dysfunction, sexual issues and incontinence in these patients complicate matters further. Anxiety may exist both before testing and while awaiting test results. Confusion over choosing from various interventions often adds to anxiety and depression in these patients. Various demographic factors and the developmental stage of the couple affect these psychological symptoms. The caregiver may undergo significant psychological turmoil while caring for a patient diagnosed with prostate cancer, which is addressed. The role of nurses in the management of prostate cancer is discussed. The present review looks at psychological issues in patients with prostate cancer from a clinical perspective, with the aim of highlighting these issues for the clinical urologist dealing with these patients. It also explores the consultation --liaison relationship between psychiatrists, psychologists and urologists as a team for the multimodal management of prostate cancer.

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“…It is possible that this may simply represent a physiological response to chronic debilitating disease. However, it is equally plausible that it may bear some relationship to the systemic inflammation that occurs in COPD, since TNF-a and other cytokines and molecules, such as nitric oxide, have been implicated in the pathogenesis of depression in several experimental models [161][162][163]. Better delineation of these issues may open new therapeutic possibilities in COPD.…”

Section: Nervous System Effectsmentioning

confidence: 99%