Systemic effects of chronic obstructive pulmonary disease

Agustí, Àlvar; Noguera, Aina; Sauleda, Jaume; Sala, Ernest; Pons, Jaume; Busquets, Xavier

doi:10.1183/09031936.03.00405703

Cited by 745 publications

(312 citation statements)

References 190 publications

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“…Besides primary effects in the lung, COPD as a chronic disease has secondary effects on other systems including skeletal muscle. Specifically, COPD is characterized by skeletal muscle dysfunction and atrophy (Agusti et al, 2003;Wouters, 2005). Chronic hypoxaemia, a common physiopathological consequence of COPD, has been proposed as a potential contributor,…”

Section: Version Postprintmentioning

confidence: 99%

Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli

Hayot

Rodriguez

Vernus

et al. 2011

Molecular and Cellular Endocrinology

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Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli, Molecular and Cellular Endocrinology (2010), doi:10.1016/j.mce.2010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Version postprintComment citer ce document : Hayot, M., Rodriguez, J., Vernus, B., Carnac, G., Jean, E., Allen, D., Goret, L., Obert, P., Candau, R., A c c e p t e d M a n u s c r i p t 2 ABSTRACTMyostatin and hypoxia signalling pathways are able to induce skeletal muscle atrophy, but whether a relationship between these two pathways exists is currently unknown. Here, we tested the hypothesis that a potential mechanism for hypoxia effect on skeletal muscle may be through regulation of myostatin. We reported an induction of myostatin expression in muscles of rats exposed to chronic hypoxia. Interestingly, we also demonstrated increased skeletal muscle myostatin protein expression in skeletal muscle of hypoxemic patients with severe Keywords : hypoxic stimulus, myostatin, skeletal muscle atrophy, COPD, myotubes Version postprintComment citer ce document : Hayot, M., Rodriguez, J., Vernus, B., Carnac, G., Jean, E., Allen, D., Goret, L., Obert, P., Candau, R., Bonnieu, A. (2011). Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli.

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Section: Version Postprintmentioning

confidence: 99%

Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli

Hayot

Rodriguez

Vernus

et al. 2011

Molecular and Cellular Endocrinology

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“…Systemic inflammation in COPD may contribute to disease morbidity and progression, including extra-pulmonary manifestations [23]. In fact, patients with COPD who have evidence of elevated inflammatory biomarkers, including serum WBC, may have increased frequency of exacerbations and increased all-cause mortality despite having similar lung function impairment [24]. It remains poorly understood why the inflammation in COPD persists, even after the inciting cause is removed (e.g.…”

Section: Discussionmentioning

confidence: 99%

Indoor Particulate Matter Associated with Systemic Inflammation in COPD

Bose¹,

Hansel²,

Tonorezos³

et al. 2015

JEP

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Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by progressive airflow obstruction, along with pulmonary and systemic inflammation. Outdoor PM has been associated with morbidity and mortality in COPD but less is known about effects of indoor air quality. In former smokers with COPD, we investigated in-home PM effects on pulmonary and systemic inflammation, symptoms, and lung function. Participants underwent in-home air monitoring for two weeks and simultaneous health assessments. Median (IQR) PM2.5 was 9 (7) µg/m 3 . Increased indoor PM2.5 was associated with increased white blood cells, predominantly neutrophils and lymphocytes, suggesting that even relatively low indoor PM2.5 may elicit a systemic inflammatory response in COPD.

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“…Системна запальна реакція або системне запалення розвивається з ранніх стадій захворювання, коли клінічні прояви мінімальні, або відсутні взагалі [7,18]. Підвищений рівень С-реак-тивного білка, що спостерігається в дослідженні, узгоджується з результатами ряду авторів [19,20]. Серед клітин, що беруть участь у реакції системно-го запалення, переважають альвеолярні макрофаги.…”

Section: обговорення результатів дослідженняunclassified

The comparative characteristic of level of matrix metalloproteinase-9 and high-sensitive C-reactive protein indicators at comorbid course of arterial hypertension and chronic obstructive pulmonary disease

Yatsenko¹

2017

ScienceRise: Medical Science

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Systemic effects of chronic obstructive pulmonary disease

Cited by 745 publications

References 190 publications

Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli

Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli

Indoor Particulate Matter Associated with Systemic Inflammation in COPD

The comparative characteristic of level of matrix metalloproteinase-9 and high-sensitive C-reactive protein indicators at comorbid course of arterial hypertension and chronic obstructive pulmonary disease

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