An immunological classification of ovine lymphomas

Dixon, Robert; Moriarty, K. M.; Johnstone, A.C.

doi:10.1016/0021-9975(84)90013-6

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…Immunophenotypic studies in sheep show that lymphoma is the B and T cell origin; however, B cell lineage was identified in most cases 5 . In addition, alimentary form lymphomas are usually originated from B cell 14 . A lymphoma case in a sheep was examined by immunohistochemical staining with CD79a, CD20, CD3, CD68 kits and, the only positivity was determined with CD79a, a diagnostic marker of B cell leukemia 11 .…”

Section: Discussionmentioning

confidence: 99%

Bir Akkaraman Koyunda T Hücreli Lenfoma

Çeribaşı¹,

Özkaraca²,

Çeribaşı³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryLympocytic T cell lymphoma was detected in liver and kidneys of a 3 year old Akkaraman sheep which was submitted to the pathology department for diagnosis. Macroscopically, nodular formations with white colour and about 1 cm size were observed in the cortex of both kidneys. The irregular nodules were observed in the liver, similar to the lesions in the kidneys. Microscopically, the nodular lesions in the liver and kidneys were consisted of uniform lymphocytic accumulations. These lymphocytes were similar to the mature lymphocytes although they were bigger and had less chromatin. Immunohistochemically, tumor cells had positivity with CD3, but negativity with CD20 and CD79a. Thus, the tumor was described as type of lymphocytic T cell lymphoma.

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Section: Discussionmentioning

confidence: 99%

Bir Akkaraman Koyunda T Hücreli Lenfoma

Çeribaşı¹,

Özkaraca²,

Çeribaşı³

et al. 2013

Kafkas Univ Vet Fak Derg

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“…Lymphoma or lymphosarcoma is a lymphoid tumor that originates in solid lymphohematopoietic organs and lymphoid aggregates associated with mucous membranes (Fighera et al, 2002). According to Vail & Young (2007), they are neoplastic diseases derived from lymph reticular cells, manifested in tissues and/or organs in which lymphoid components are aggregated, exhibiting malignant biological behavior.…”

Section: Introductionmentioning

confidence: 99%

“…In ruminants, lymphoma has been more diagnosed in dairy cattle , and its occurrence is associated with the bovine Leukemia virus (BLV). Sheep is also susceptible to the virus, especially when young (Anjos, 2010), sporadically, being found mainly in the inspection of animals in slaughterhouses (Dixon, 1984). It is reported that about 30-60% infected young sheep develop B-cell lymphosarcoma (Valli, 2007).…”

Section: Introductionmentioning

confidence: 99%

Multicentric lymphoma in sheep (case report)

Santos

Kalb

Barbosa

et al. 2020

Rev. bras. saúde prod. anim.

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The present study describes a case report in sheep with multicentric lymphoma. Clinical examination revealed the animal presented tachycardia, tachypnea, congested ocular mucous membranes, fever, cachexia, mild dehydration, decreased ruminal motility, difficulty in standing, and dysuria. Supportive treatment and complementary examination (complete blood count, radiography, ultrasound and abdominocentesis) were performed. The results showed neutrophilic leukocytosis, persistent lymphocytosis, exudate with high cell concentration, and imaging examination showed abundant fluid in the abdominal cavity, and enlarged iliac and mesenteric lymph nodes. Due to the severe clinical condition, the animal died and referred for necropsy. Samples from different organs were collected for histopathological analysis. At necropsy, abundant light brown exudate was observed in the thoracic and abdominal cavities, multiple white lobulated masses in different organs, in addition to pink, irregular, multifocal and coalescent nodules in the omentum, with neoplastic cells arranged in cords and cloak of cells supported by a thin fibrovascular stroma. Macroscopic and microscopic findings are characteristic of multicentric lymphoma.

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“…The following lymphomas are recognised in sheep: lymphoblastoid, pro-lymphocyte, lymphocyte, and reticular cell; however, there has been little development in immunophenotyping (4). Some contributions to immunophenotyping in sheep were developed by Dixon et al (5), who proposed a technique for classifying lymphomas according to their origins in B or T lymphocytes; however, it has not been adopted in routine use, and the majority of the specific molecular markers now used in other species are absent. The characteristics of lymphomas and leukaemias differ with the animal's age when it appears, i.e., between young and adult animals.…”

Section: Introductionmentioning

confidence: 99%

Descripción morfológica e inmunohistoquímica de un linfoma en un cordero de dos meses de edad usando los marcadores MUM1/IRF4, CD79a, CD3, CD10 y Ki67

2019

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En este artículo se describe morfológicamente un caso de linfoma de presentación temprana en la especie ovina, el cual se caracterizó por lo inusual de su historia clínica y lo avanzado de las lesiones. El tumor primario se localizó en la piel del carpo y se observaron metástasis en el cerebro, el ojo derecho, todos los lóbulos pulmonares, el miocardio y endocardio del corazón, la glándula adrenal izquierda, el nervio vago en su porción abdominal, la serosa del rumen, el cuerpo vertebral lumbar L3, los linfonodos submandibulares, mediastínicos y mesentéricos. El examen histopatológico reveló un linfoma no Hodgkin de células grandes. El análisis inmunohistoquímico se realizó con anticuerpos para MUM-1/IRF-4, CD79a, CD3, CD10 y Ki-67, los cuales se usaron por primera vez como marcadores para caracterizar un linfoma en esta especie. El resultado reveló que se trató de un linfoma de células-B

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An immunological classification of ovine lymphomas

Cited by 8 publications

References 20 publications

Bir Akkaraman Koyunda T Hücreli Lenfoma

Bir Akkaraman Koyunda T Hücreli Lenfoma

Multicentric lymphoma in sheep (case report)

Descripción morfológica e inmunohistoquímica de un linfoma en un cordero de dos meses de edad usando los marcadores MUM1/IRF4, CD79a, CD3, CD10 y Ki67

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