1984
DOI: 10.1136/ard.43.3.470
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An immunohistological study of secondary Sjogren's syndrome.

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Cited by 52 publications
(17 citation statements)
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References 15 publications
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“…The infiltrate is composed of T and B lymphocytes, plasma cells and a small number of macrophages [1,2]. Most of the T cells are CD4 [3][4][5] bearing the phenotype of memory cells [6,7] with 15-20% being CD8 cells [3,4]. A large proportion of the T cells express class II MHC antigens [8][9][10], suggesting activation, though few (4%) express the T cell activation antigen.…”
Section: Introductionmentioning
confidence: 99%
“…The infiltrate is composed of T and B lymphocytes, plasma cells and a small number of macrophages [1,2]. Most of the T cells are CD4 [3][4][5] bearing the phenotype of memory cells [6,7] with 15-20% being CD8 cells [3,4]. A large proportion of the T cells express class II MHC antigens [8][9][10], suggesting activation, though few (4%) express the T cell activation antigen.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, a number of serum samples from idiotype-positive patients were studied when the disease was inactive and serial bleeds were assessed (see Results). The sera from 27 patients with rheumatoid arthritis (each ofwhom met the revised criteria of the American Rheumatism Association [12]) (mean age = 57±13.4; F/M = 14:13), 20 patients with primary Sjbgren's syndrome (who fulfilled criteria for the disease [13]) (mean age = 58±14.5; F/M = 15:5), 17 patients with idiopathic myositis (14) (mean age = 46±14.5; F:M 12:5), and 28 normal controls (mean age = 39±1 1; F/M = 19:9) were also examined.…”
Section: Introductionmentioning
confidence: 99%
“…Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by the clinical manifestations of xerostomia and keratoconjunctivitis sicca (KCS) related to lymphocytic infiltration and dysfunction of the salivary and lacrimal glands (1)(2)(3)(4)(5)(6)(7). SS has been divided into primary and secondary forms, dependent on the presence of another autoimmune or connective tissue disease (7).…”
mentioning
confidence: 99%
“…SS has been divided into primary and secondary forms, dependent on the presence of another autoimmune or connective tissue disease (7). Currently, the diagnosis of SS is defined by the presence of KCS, as determined by complete ophthalmologic evaluation, and a positive sublabial salivary gland (SSG) biopsy result (5,8,9). Focal sialadenitis of grade IV (lo), which corresponds to a lymphocytic focus score > 1 focusl4 mm2 of SSG tissue, is a widely accepted criterion for the histologic confirmation of the diagnosis of SS (1)(2)(3)(4)(5)(6)(7)(8)(9).…”
mentioning
confidence: 99%
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