An Immunohistochemical Study of bcl-2 Protein Expression in Keratoacanthoma, as Compared to Squamous-Cell Carcinoma and Basal-Cell Carcinoma

Bergman, Reuven; Amichai, Boaz; Kilim, Sigalit; Kerner, Hedviga; Ben-Arye, Y.; Halevy, Sima; Friedman‐Birnbaum, Rachel

doi:10.1097/00000372-199710000-00070

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2013

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 A plethora of ancillary studies have emerged to help differentiate these 2 morphologically similar but biologically different tumors (summarized in Table 2). 18-36 While most focus on immunohistochemical stains, select studies utilize imaging techniques. In the former group, the most promising 3 stains appeared to be peanut lectin (PNA), elastic tissue stain, and markers indicative of end-stage apoptosis (TUNEL) and cell adhesion (E-cadherin).…”

Section: Discussionmentioning

confidence: 99%

Histopathology of Keratoacanthoma Revisited

2013

View full text Add to dashboard Cite

Our findings indicate that, in the appropriate clinical setting, a smaller orificial size, although predictive of a KA, in itself is not sufficient for a definitive diagnosis. Given that a major limitation is that this is a function of age of the lesion as orificial size depends on the evolution stage of the neoplasm with the largest diameter often evident in lesions at early stages of regression, for now correlation with histopathologic features such as presence of an epithelial lip, sharp demarcation of tumor from stroma, and fibrosis (present in >95% of cases of KAs) is required.

show abstract