Histopathology of Keratoacanthoma Revisited

Abstract

Our findings indicate that, in the appropriate clinical setting, a smaller orificial size, although predictive of a KA, in itself is not sufficient for a definitive diagnosis. Given that a major limitation is that this is a function of age of the lesion as orificial size depends on the evolution stage of the neoplasm with the largest diameter often evident in lesions at early stages of regression, for now correlation with histopathologic features such as presence of an epithelial lip, sharp demarcation of tumor from stroma, and fibrosis (present in >95% of cases of KAs) is required.

Solitary keratoacanthoma of the lip vermilion

“…There were sixteen males and five females (male:female ratio was 3.2), suggesting a predilection of S-KA for man while skin lesions do not see to have a preponderance of any gender 24 . The mean age at clinical presentation was 51.8 years (range 14-79 years).…”

“…Thus his immunological imbalance added to a reported sunlight chronic exposure might have had role in the S-KA development 10 . The second individual, 20 years old, was a "goza" (also called narghile, hookah, shisha, and water-pipe) user 15 which mutagenic potential may have a role in the development of S-KA 24 . Disregarding those two patients, the main age at clinical presentation rose to 53 years old and 17/21 1, 3-9, 11, 13, 14, 16, 17 patients were above 45 years old.…”