An Immunocompromised Child with Bloodstream Infection Caused by Two Escherichia coli Strains, One Harboring NDM-5 and the Other Harboring OXA-48-Like Carbapenemase

Hasassri, M. Earth; Boyce, Thomas G.; Norgan, Andrew P.; Cunningham, Scott A.; Jeraldo, Patricio; Weissman, Scott J.; Patel, Robin; Banerjee, Ritu; Pogue, Jason M.; Kaye, Keith S.

doi:10.1128/aac.03118-15

Cited by 11 publications

(4 citation statements)

References 18 publications

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“…Mainly found in Klebsiella species, reports on the detection of bla oxa -carrying E. coli have increased in the last 3 years in different parts of the world, being reported in studies in Myanmar [85], the United States [86] and Thailand [87]. In all three studies, the isolated strains were co-expressing bla OXA-48 or its variants and bla NDM5 .…”

Section: Carbapenem-hydrolyzing Oxacillinase-48 (Oxa-48)mentioning

confidence: 86%

Antimicrobial Resistance in Escherichia coli

Galindo-Méndez¹

2020

E. Coli Infections - Importance of Early Diagnosis and Efficient Treatment

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In the last decades, antimicrobial resistance has become a global threat to public health systems worldwide. Among those bacteria that pose the greatest threat to human health because of its growing resistance to antibiotics are the members of the Enterobacteriaceae family, particularly Escherichia coli and Klebsiella spp. Among the different antibiotic-resistant mechanisms developed by bacteria, the ones found in Enterobacteriaceae are more diverse than those in other families and include resistance to different antibiotic groups, advantages that partially explain why these microorganisms are among the most common causes of antibiotic-resistant bacterial infections in humans. Due to the continuously increasing number of infections caused by multidrug-resistant E. coli due to its ease of transmission via the fecaloral route among humans and from environmental sources, the understanding of the epidemiology of these strains and their mechanisms of resistance are key components in the fight against these infections.

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Section: Carbapenem-hydrolyzing Oxacillinase-48 (Oxa-48)mentioning

confidence: 86%

Antimicrobial Resistance in Escherichia coli

Galindo-Méndez¹

2020

E. Coli Infections - Importance of Early Diagnosis and Efficient Treatment

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“…In the United States, a K. pneumoniae isolate carrying bla NDM-1 and bla OXA-232 was reported in another patient transferred from India (31). However, bla NDM-5 and bla have been reported only once before in the same patient but in different E. coli isolates (32). In summary we describe the occurrence of two clinically important carbapenemases (the "evil twins"), bla OXA-181 (chromosomally encoded) and bla NDM-5 (plasmid encoded), in a carbapenem-resistant K. pneumoniae clinical isolate in the United States.…”

mentioning

confidence: 99%

NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas

Rojas

Hujer

Rudin

et al. 2017

Antimicrob Agents Chemother

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Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant Klebsiella pneumoniae ST147 isolate harboring bla NDM-5 and bla OXA-181 from a young man who underwent abdominal surgery in India. bla NDM-5 was located on an IncFII plasmid of Ϸ90 kb, whereas bla OXA-181 was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS26 and a "hot-spot region" in the IncFII plasmid.

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“…However, there are no clinically available beta-lactamase inhibitors that inactivate MBLs. Published studies report successful use of combination ceftazidime-avibactam and aztreonam to treat patients infected with MBLs [7] , [8] , [9] , [10] , [11] , [12] . In vitro data suggests the combination is stable in the presence of the enzymes as aztreonam is not hydrolyzed by MBLs and avibactam will inhibit most aztreonam-hydrolyzing betalactamases.…”

Section: Discussionmentioning

confidence: 99%

Combination antibiotic therapy for treatment of a patient with infected prosthesis and peri-prosthetic abscess due to Klebsiella pneumoniae harboring New Delhi Metallo (NDM) beta-lactamase

Santana

Wong

Urban

et al. 2022

IDCases

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Treatment options for patients infected with multi-drug resistant gram-negative bacteria harboring metallo-beta-lactamases (MBLs) requires precision therapy. We present the case of a 20 year-old male with a right distal femoral peri-prosthetic abscess with presumed infected hardware and osteomyelitis in whom four multi-drug resistant gram negative bacteria were isolated. The rapid identification of an MBL producing organism, novel combination of therapy, and prompt infection prevention enforcement and education led to appropriate treatment of our patient as well as prevention of spread of organisms during and after hospitalization. This case illustrated successful management of multiple challenges faced by patients infected and/or harboring extensively resistant bacteria.

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An Immunocompromised Child with Bloodstream Infection Caused by Two Escherichia coli Strains, One Harboring NDM-5 and the Other Harboring OXA-48-Like Carbapenemase

Cited by 11 publications

References 18 publications

Antimicrobial Resistance in Escherichia coli

Antimicrobial Resistance in Escherichia coli

NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas

Combination antibiotic therapy for treatment of a patient with infected prosthesis and peri-prosthetic abscess due to Klebsiella pneumoniae harboring New Delhi Metallo (NDM) beta-lactamase

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