served as action editor for this article. Preparation of this article was supported by the John D. and Catherine T. MacArthur Foundation Network on Determinants and Consequences of Health-Promoting and Disease-Preventing Behavior, chaired by Judith Rodin. We would like to thank Burton Singer and George Kaplan for consulting with us on this article, Kenneth Wallston for his helpful review and comments on an earlier draft, members of the MacArthur Network for their input, and Lynae Darbes for her assistance in the research.

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A live-attenuated, intranasal respiratory syncytial virus (RSV) candidate vaccine, cpts-248/404, was tested in phase 1 trials in 114 children, including 37 1-2-month-old infants-a target age for RSV vaccines. The cpts-248/404 vaccine was infectious at 104 and 105 plaque-forming units in RSV-naive children and was broadly immunogenic in children >6 months old. Serum and nasal antibody responses in 1-2 month olds were restricted to IgA, had a dominant response to RSV G protein, and had no increase in neutralizing activity. Nevertheless, there was restricted virus shedding on challenge with a second vaccine dose and preliminary evidence for protection from symptomatic disease on natural reexposure. The cpts-248/404 vaccine candidate did not cause fever or lower respiratory tract illness. In the youngest infants, however, cpts-248/404 was unacceptable because of upper respiratory tract congestion associated with peak virus recovery. A live attenuated RSV vaccine for the youngest infant will use cpts-248/404 modified by additional attenuating mutations.

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Background-Individuals with asthma have been reported to be at increased risk of invasive pneumococcal disease. These findings need to be confirmed in a different population-based study setting.

In the original version of Figure 2B, two of the patient identifiers were incorrectly noted. OS-11 and OS-12 were listed twice. The second instances should have been labeled as CID-11 and CID-12, respectively. The correct figure panel is below.The authors regret the error.

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