An immune‐complex glomerulonephritis of Chinook salmon, Oncorhynchus tshawytscha (Walbaum)

Abstract

Chinook salmon from New Zealand were shown to have a generalized membranous glomerulonephritis that was most severe in large fish. Marked thickening of the glomerular basement membrane was the most consistent lesion, with the presence of an electron-dense deposit beneath the capillary endothelium.Severely affected glomeruli also had expansion of the mesangium and loss of capillaries,synechiae of the visceral and parietal epithelium and mild fibrosis of Bowmans capsule. Chinook salmon from British Columbia, Canada with bacterial kidney disease caused by Renibacterium salmoninarum had similar histological lesions. They also had thickened glomerular basement membranes that were recognized by rabbit antiserum to rainbow trout immunoglobulin. This was true only when frozen sections of kidney were used and not formalin-fixed tissue. An attempt to experimentally produce a glomerulopathy in rainbow trout by repeated immunization with killed R. salmoninarum was not successful. Case records from the Fish Pathology Laboratory at the University of Guelph over a 10-year period revealed that a range of species were diagnosed with glomerulopathies similar to those seen in Chinook salmon. The majority of these cases were determined to have chronic inflammatory disease. This report has identified the presence of immunoglobulin within thickened basement membranes of Chinook salmon with glomerulonephritis and supports the existence of type III hypersensitivity in fish.

Monoclonal antibodies to snakehead, Channa striata immunoglobulins: Detection and quantification of immunoglobulin-positive cells in blood and lymphoid organs

“…An immune-complex glomerulonephritis of Chinook salmon, Oncorhynchus tshawytscha suggestive of type III hypersensitivity [28] and immunoglobulinpositive deposits in glomerular basement membrane of bacterial kidney disease infected rainbow trout [29] also support the present observation. A few cells in blood vessels of kidney showing reactivity to C9 MAb are presumed to be circulating B-lymphocytes.…”

A transcriptome analysis focusing on inflammation-related genes of grass carp intestines following infection with Aeromonas hydrophila

“…In this study, we provide novel intestinal transcriptome sequence data with a special focus on the discovery of inflammation-related genes and their signaling networks. These data will allow us to better understand not only the mechanism of intestinal inflammation triggered by bacterial pathogens, but also the pathogenesis of enteritis and other fish inflammatory diseases, like aerocystitis55, mycobacteriosis56 and glomerulonephritis57. Additionally, and more practically, the data might aid in the development of therapeutic targets for fish diseases associated with inflammation58.…”

Pathological and immunological responses associated with differential survival of Chinook salmon following Renibacterium salmoninarum challenge

“…Mean values for each time point were calculated using only the positive fish, and the number of positive fish divided by the number of fish examined is shown above each data point. WI: from Lake Michigan, Wisconsin; Green River: from Green River, Washington antigen-antibody complex deposition in the glomeruli (Sami et al 1992, Lumsden et al 2008). This observation led to the hypothesis that an overzealous humoral response could exacerbate BKD-associated pathology (Wiens & Kaattari 1999).…”