An fMRI investigation of syllable sequence production

Bohland, Jason W.; Guenther, Frank H.

doi:10.1016/j.neuroimage.2006.04.173

Cited by 453 publications

(490 citation statements)

References 126 publications

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“…The no shift -baseline (t > 3.63, df = 9) contrast revealed a large network of active regions which has been previously implicated in speech production (Bohland and Guenther, 2006;Guenther et al, 2006), including bilateral peri-Sylvian auditory cortex, ventral Rolandic cortex, medial prefrontal cortex, anterior striatum, ventral thalamus, and superior cerebellum (peaking in lobule 6). Activations in the shift -baseline contrast (t > 3.41, df = 9) overlap those of the no shift -baseline contrast with two notable exceptions: extension of the superior cerebellar activation anterior-medially to include the cerebellar vermis bilaterally, and activation at the junction of the calcarine and parietal-occipital sulci.…”

Section: Neural Responsesmentioning

confidence: 90%

“…In the current study, this activity may contribute to auditory feedback control by increasing the influence of sensory input on the motor output system. Activation of right cerebellar lobule 8 has been associated with increased sequence complexity (Bohland and Guenther, 2006) and limb motor task complexity (Habas et al, 2004;Habas and Cabanis, 2006). This area has also been associated specifically with motor error correction, becoming active when unexpected execution errors were induced during a reaching task (Diedrichsen et al, 2005).…”

Section: The Auditory Feedback Control Networkmentioning

confidence: 99%

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Neural mechanisms underlying auditory feedback control of speech

2008

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The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling. Neural responses were measured while subjects spoke monosyllabic words under two conditions: (i) normal auditory feedback of their speech, and (ii) auditory feedback in which the first formant frequency of their speech was unexpectedly shifted in real time. Acoustic measurements showed compensation to the shift within approximately 135 ms of onset. Neuroimaging revealed increased activity in bilateral superior temporal cortex during shifted feedback, indicative of neurons coding mismatches between expected and actual auditory signals, as well as right prefrontal and Rolandic cortical activity. Structural equation modeling revealed increased influence of bilateral auditory cortical areas on right frontal areas during shifted speech, indicating that projections from auditory error cells in posterior superior temporal cortex to motor correction cells in right frontal cortex mediate auditory feedback control of speech.

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Section: Neural Responsesmentioning

confidence: 90%

Section: The Auditory Feedback Control Networkmentioning

confidence: 99%

Neural mechanisms underlying auditory feedback control of speech

2008

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“…According to previous research on normal speech, the putamen is also a node of the network for phonetic encoding and syllable sequence organization during word production (Bohland and Guenther, 2006;Indefrey and Levelt, 2004). The putamen's involvement in stuttering has also been well documented.…”

Section: The Neural Substrates For Atypical Planning Process In Stuttmentioning

confidence: 99%

“…It should be noted, however, that their study did not control for utterance length and syllable frequency. In our study, we used word length to vary computational load and at the same time controlled for the utterance length (through repeated production of the same syllable, Bohland and Guenther, 2006) and syllable frequency. Fig.…”

Section: Introductionmentioning

confidence: 99%

The neural substrates for atypical planning and execution of word production in stuttering

Chen

Ning

et al. 2010

Experimental Neurology

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a b s t r a c t a r t i c l e i n f oUsing an fMRI-based classification approach and the structural equation modeling (SEM) method, this study examined the neural bases of atypical planning and execution processes involved in stuttering. Twelve stuttering speakers and 12 controls were asked to name pictures under different conditions (single-syllable, multi-syllable, or repeated-syllable) in the scanner. The contrasts between conditions provided information about planning and execution processes. The classification analysis showed that, as compared to nonstuttering controls, stuttering speakers' atypical planning of speech was evident in their neural activities in the bilateral inferior frontal gyrus (IFG) and right putamen and their atypical execution of speech was evident in their activations in the right cerebellum and insula, left premotor area (PMA), and angular gyrus (AG). SEM results further revealed two parallel neural circuits-the basal ganglia-IFG/PMA circuit and the cerebellum-PMA circuit-that were involved in atypical planning and execution processes of stuttering, respectively. The AG appeared to be involved in the interface of atypical planning and execution in stuttering. These results are discussed in terms of their implications to the theories about stuttering and to clinical applications.

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“…Studies utilizing functional neuroimaging tools such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) provide insight into the role of the basal ganglia in both normal and disordered speech. Of the subcortical nuclei comprising the basal ganglia pathways, the putamen is most commonly associated with speech and voice production in neuroimaging studies (Bohland & Guenther, 2006; Brown et al., 2009; Manes et al., 2014; Tourville & Guenther, 2011). Researchers have reported increased bilateral putamen activation during both speech and nonspeech vocal tract movements using fMRI (Brown et al., 2009; Chang, Kenney, Loucks, Poletto, & Ludlow, 2009; Parkinson et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

et al. 2018

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IntroductionSpeech impairment in Parkinson's disease (PD) is pervasive, with life‐impacting consequences. Yet, little is known about how functional connections between the basal ganglia and cortex relate to PD speech impairment (PDSI). Whole‐brain resting‐state connectivity analyses of basal ganglia nuclei can expand the understanding of PDSI pathophysiology.MethodsResting‐state data from 89 right‐handed subjects were downloaded from the Parkinson's Progression Markers Initiative database. Subjects included 12 older healthy controls (“OHC”), 42 PD patients without speech impairment (“PDN”), and 35 PD subjects with speech impairment (“PDSI”). Subjects were assigned to PDN and PDSI groups based on the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) Part III speech item scores (“0” vs. “1–4”). Whole‐brain functional connectivity was calculated for four basal ganglia seeds in each hemisphere: putamen, caudate, external globus pallidus (GPe), and internal globus pallidus (GPi). For each seed region, group‐averaged connectivity maps were compared among OHC, PDN, and PDSI groups using a multivariate ANCOVA controlling for the effects of age and sex. Subsequent planned pairwise t‐tests were performed to determine differences between the three groups using a voxel‐wise threshold of p < 0.001 and cluster‐extent threshold of 272 mm3 (FWE<0.05).ResultsIn comparison with OHCs, both PDN and PDSI groups demonstrated significant differences in cortical connectivity with bilateral putamen, bilateral GPe, and right caudate. Compared to the PDN group, the PDSI subjects demonstrated significant differences in cortical connectivity with left putamen and left GPi. PDSI subjects had lower connectivity between the left putamen and left superior temporal gyrus compared to PDN. In addition, PDSI subjects had greater connectivity between left GPi and three cortical regions: left dorsal premotor/laryngeal motor cortex, left angular gyrus, and right angular gyrus.ConclusionsThe present findings suggest that speech impairment in PD is associated with altered cortical connectivity with left putamen and left GPi.

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An fMRI investigation of syllable sequence production

Cited by 453 publications

References 126 publications

Neural mechanisms underlying auditory feedback control of speech

Neural mechanisms underlying auditory feedback control of speech

The neural substrates for atypical planning and execution of word production in stuttering

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

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