An extrapyramidal choreiform syndrome caused by amphetamine addiction

Lundh, Håkan; Tunving, K

doi:10.1136/jnnp.44.8.728

Cited by 58 publications

(28 citation statements)

References 4 publications

(1 reference statement)

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“…Our review of the literature turned up only three case reports on stimulant abuse and hyperkinetic movement disorders (Mattson and Calvery, 1968;Lundh and Tunving, 1981;Sperling and Horowitz, 1994) and only one of these pertained directly to MA (Sperling and Horowitz, 1994). This is surprising because of the overwhelming evidence from animal studies that MA exposure induced increased locomotor activity and stereotypies.…”

Section: Clinical Studiesmentioning

confidence: 85%

“…At times, the movements were rapid and ballistic and affected gait. In some individuals, the abnormal movements occurred during abstinence and persisted for a year or longer following discontinuation (Lundh and Tunving, 1981). Sperling and Horowitz (1994) described a 50-yearold male who presented to an emergency room with choreiform movements of the upper extremities, head, and neck following use of crystallized MA.…”

Section: Clinical Studiesmentioning

confidence: 99%

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Do Preclinical Findings of Methamphetamine-Induced Motor Abnormalities Translate to an Observable Clinical Phenotype?

Caligiuri

Buitenhuys

2005

Neuropsychopharmacol

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This review summarizes the preclinical literature of the effects of methamphetamine (MA) on subcortical dopaminergic and GABAergic mechanisms underlying motor behavior with the goal of elucidating the clinical presentation of human MA-induced movement disorders. Acute and chronic MA exposure in laboratory animal can lead to a variety of motor dysfunctions including increased locomotor activity, stereotypies, diminished or enhanced response times, and parkinsonian-like features. With the exception of psychomotor impairment and hyperkinesia, MA-induced movement disorders are not well documented in humans. This review attempts to draw parallels between the animal and human changes in basal ganglia neurochemistry associated with MA exposure and offers explanations for why a parkinsonian phenotype is not apparent among individuals who use and abuse MA. Significant differences in the expression of neurotoxicity and presence of multiple environmental and pharmacologic confounds may account for the lack of a parkinsonian phenotype in humans despite evidence of altered dopamine function.

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Section: Clinical Studiesmentioning

confidence: 85%

Section: Clinical Studiesmentioning

confidence: 99%

Do Preclinical Findings of Methamphetamine-Induced Motor Abnormalities Translate to an Observable Clinical Phenotype?

Caligiuri

Buitenhuys

2005

Neuropsychopharmacol

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“…Seizures and stroke have also been reported in the context of MA intoxication in both emergency department and hospital settings (Westover et al, 2007; Perez et al, 1998; Richards et al, 1999). Other MA-related neurological complications include movement disorders; during intoxication, users may exhibit hyperkinetic movements, repetitive or stereotyped behaviors, (Mattson and Calvery, 1968; Sperling and Horowitz, 1994) or choreoathetoid movement disorders (Lundh and Tunving, 1981; Rhee et al, 1998). .…”

Section: Health Consequences Of Ma Usementioning

confidence: 99%

The Methamphetamine Problem in the United States

Gonzales

Mooney

Rawson

2010

Annu. Rev. Public Health

291

238

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Significant public health problems associated with methamphetamine (MA) production and use in the United States have emerged over the past 25 years. Although the popular press (Newsweek, Aug 8, 2008), has called MA “America’s Most Dangerous Drug” there has been considerable controversy about the size of the problem. Epidemiological indicators have given a mixed picture. National surveys of the adult U.S. population and school-based populations have consistently been used to support the position that MA use is a relatively minor concern (NSDUH, 2006; Johnston & O’Malley, 2007). However, many other data sources, including law-enforcement groups, welfare agencies, substance abuse treatment program admission data, data on criminal justice populations, and state/county executives indicate that MA is a very significant public health problem for many communities throughout much of the country (NDIC, 2007b; NACO, 2005, 2006; NIDA CEWG, 2007). In this article, we describe (1) the historical underpinnings of the MA problem, (2) trends in the epidemiological nature of the MA problem, (3) key subgroups at risk for MA problems, (4) the health and social factors associated with MA use, (5) interventions available for addressing the MA problem, and (5) lessons learned related to the MA problem.

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“…89 There have been numerous reports of choreoathetoid movements (involuntary purposeless and uncontrollable movements with features of both chorea and athetosis) in patients using or abusing amphetamines. 46,68,69,90–94 In one report, patients with underlying chorea (Sydenham, Huntington, and Lupus) were given an intravenous dose of amphetamine to assess its effect on their baseline movements. In each of these patients, amphetamine dramatically worsened their underlying chorea.…”

Section: Choreoathetoid Movements and Dyskinesiasmentioning

confidence: 99%

Neurologic Manifestations of Chronic Methamphetamine Abuse

Rusyniak

2013

Psychiatric Clinics of North America

106

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COMMENTARY ON METHAMPHETAMINE ABUSE FOR PSYCHIATRIC PRACTICE Every decade seems to have its own unique drug problem. The 1970s had hallucinogens, the 1980s had crack cocaine, the 1990s had designer drugs, the 2000s had methamphetamine (Meth), and in the 2010s we are dealing with the scourge of prescription drug abuse. While each of these drug epidemics has distinctive problems and history, the one with perhaps the greatest impact on the practice of Psychiatry is Meth. By increasing the extracellular concentrations of dopamine while slowly damaging the dopaminergic neurotransmission, Meth is a powerfully addictive drug whose chronic use preferentially causes psychiatric complications. Chronic Meth users have deficits in memory and executive functioning as well as higher rates of anxiety, depression, and most notably psychosis. It is because of addiction and chronic psychosis from Meth abuse that the Meth user is most likely to come to the attention of the practicing Psychiatrist/Psychologist. Understanding the chronic neurologic manifestations of Meth abuse will better arm practitioners with the diagnostic and therapeutic tools needed to make the Meth epidemic one of historical interest only.

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An extrapyramidal choreiform syndrome caused by amphetamine addiction

Cited by 58 publications

References 4 publications

Do Preclinical Findings of Methamphetamine-Induced Motor Abnormalities Translate to an Observable Clinical Phenotype?

Do Preclinical Findings of Methamphetamine-Induced Motor Abnormalities Translate to an Observable Clinical Phenotype?

The Methamphetamine Problem in the United States

Neurologic Manifestations of Chronic Methamphetamine Abuse

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