An extragonadal male antifertility agent

Coppola, J. A.

doi:10.1016/0024-3205(69)90291-4

Cited by 100 publications

(48 citation statements)

References 3 publications

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“…The concentrations of sodium, potassium, acid phosphatase, alkaline phosphatase and GPC were not altered. a-Chlorohydrin and epididymal plasma composition (Coppola, 1969;Samojlik & Chang, 1970), the guinea-pig (Ericsson & Baker, 1970), the monkey (Kirton et al, 1970), the ram (Kreider & Dutt, 1970), the boar (Johnson & Pursel, 1972) and the hamster (Lubicz-Nawrocki & Chang, 1974), but is apparently without action in the mouse and rabbit (Ericsson, 1970 The results of the present study amplify the previous report (Ericsson, 1970) that -chlorohydrin is without action in the rabbit. Also, in agreement with Turner (1971), 8 mg/kg/3 days would seem to be about the minimum antifertility regimen in the rat.…”

Section: Methodssupporting

confidence: 83%

“…In contrast, the level of GPC increased in rabbit epididymal plasma in all treatment groups, although in the rat GPC remained within normal limits. It is, therefore, clear that the antifertility effect of -chlorohydrin in the rat is not the result of an action as a metabolic antagonist of glycerol as has been previously suggested (Coppola, 1969;Gunn et al, 1969). This endorses the findings of Brooks et al (1974).…”

Section: Methodssupporting

confidence: 75%

“…acting as a metabolic antagonist of glycerol (Coppola, 1969;Gunn et al, 1969) ; interference with the absorptive role of the junctional region of the ductuli efferentes and caput epididymidis (Cooper et al, 1974); creation of a hostile environment for spermatozoa 118 D. J. Back et al possibly by alteration of fluid chemistry within the epididymal duct (Kreider & Dutt, 1970) ; causing changes in the vascular supply to the caput epididymidis thereby possibly hindering the maturation of contained spermatozoa (Ericsson, 1970); interference with sperm motility and transport within the female tract (Vickery et al, 1974).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of -Chlorohydrin on the Composition of Rat and Rabbit Epididymal Plasma: A Possible Explanation of Species Difference

Back¹,

Glover²,

Shenton³

et al. 1975

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Summary. The relationship between the antifertility effect of \g=a\-chlorohydrin and changes in composition of luminal plasma from the cauda epididymidis of rats and rabbits has been investigated.At each dose regimen studied, the fertilizing capacity of rats treated with \g=a\-chlorohydrin was reduced to zero. The levels of sodium, potassium, glycerylphosphorylcholine (GPC), acid phosphatase and alkaline phosphatase in epididymal plasma were not markedly affected by drug treatment. The most noticeable change was a considerable increase in the concentration of lactic dehydrogenase (LDH) at all dose levels and of glutamic-oxaloacetic transaminase (GOT) after 7 days of treatment with 8 and 16 mg/kg. The effect of cold shock on the composition of epididymal plasma showed that LDH and GOT are, at least in part, derived from spermatozoa.In contrast, \g=a\-chlorohydrin did not have an antifertility action in the rabbit, and the only notable change in the composition of epididymal plasma was an increase in the level of GPC.These results provide evidence that, in the rat, \g=a\-chlorohydrin or a metabolite primarily exerts its antifertility effect by a direct action on the spermatozoa, whilst in the rabbit a barrier may exist to the entrance of the drug into the lumen of the epididymal duct.

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Section: Methodssupporting

confidence: 83%

Section: Methodssupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

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The Effects of -Chlorohydrin on the Composition of Rat and Rabbit Epididymal Plasma: A Possible Explanation of Species Difference

Back¹,

Glover²,

Shenton³

et al. 1975

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“…-Chlorohydrin causes reversible sterility in male rats and several other species (see Coppola, 1969; Ericsson & Baker, 1970;Krieder & Dutt, 1970;Johnson & Pursel, 1972) apparently by affecting the metabolic capabilities of spermatozoa in the cauda epididymidis. Sufficient evidence has now accumulated to suggest that a-chlorohydrin is not itself the active compound causing disruption of sperm metabolism.…”

Section: Introductionmentioning

confidence: 99%

The interaction of -chlorohydrin with glycerol kinase

De¹

1979

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“…The drug also leads to reduced sperm motility (Coppola, 1969;Samojlik & Chang, 1970;Kreider & Dutt, 1970;Johnson & Pursel, 1972;Brown & White, 1973;Vickery, Erickson & Bennett, 1974;Homonnai et al, 1975). It has been suggested that the inhibition of glycolysis prevents normal ATP production, leading to insufficient energy supply for motility Suter et al, 1975;Homonnai et al, 1975).…”

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confidence: 99%