An extract from the brown alga Bifurcaria bifurcata induces irreversible arrest of cell proliferation in a non-small-cell bronchopulmonary carcinoma line

Abstract

In this study, the antiproliferative activity of a crude extract isolated from Bifurcaria bifurcata (Velley) Ross, a common marine brown alga of the Atlantic shores of Europe, was investigated. Its antiproliferative effect on asynchronous cells of a human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6), particularly chemoresistant, was expected in vitro. Cell growth appeared to be inhibited in the G1 phase of the cell cycle, and kinetic studies in pretreated cells showed that this growth arrest was irreversible. These events are related to a terminal differentiation induction.

Bifurcaria bifurcata: a key macro‐alga as a source of bioactive compounds and functional ingredients

“…For antiproliferative activity, it is possible to see that both fractions induced inhibition on the cell proliferation. The same effects were observed in NSCLC‐N6 cells by B. bifurcata crude extract, which induced irreversible arrest of cell proliferation (Moreau et al ., ). This fact suggests one possible mechanism route associated with the B. bifurcata ‐induced inhibition of the growth of Caco‐2 and HepG‐2 cells; however, more studies are necessary to validate this hypothesis.…”

Antioxidant and antitumoural activities of some Phaeophyta from Brittany coasts

“…While confirming the high bioactivity of Sargassaceae, this screening provided the first evidence of cytotoxic activities by the C. tamariscifolia and H. siliquosa extracts. The demonstration of cytotoxic activity in B. bifurcata extracts (Culioli et al, 2004;Moreau et al, 2006) has led to the identification of an acyclic diterpene, bifurcariol, as the cytotoxic compound. Further to studies about cytotoxic activity by species of the Cystoseira genus, various diterpenes have been identified as the bioactive compounds in C. crinita (Fisch et al, 2003), C. myrica (Ayyad, Abdel-Halim, Shier, & Hoye, 2003) and Cystoseira usneoides (Urones et al, 1992).…”

“…Among them, only few species, mainly brown algae, have been investigated for their antioxidant capacities (Cerantola, Breton, Ar Gall, & Deslandes, 2006;Connan, Delisle, Deslandes, & Ar Gall, 2006;Connan, Deslandes, & Ar Gall, 2007;Le Lann, Jegou, & Stiger-Pouvreau, 2008), their anti-fouling (Hellio, Bremer, Pons, Le Gal, & Bourgougnon, 2000;Hellio et al, 2004;Plouguerné et al, 2008) and antitumoural (Moreau et al, 2006) activities. These studies have highlighted the great potential of brown macroalgae in the search for bioactive molecules.…”

Eleganolone, a Diterpene from the French Marine Alga Bifurcaria bifurcata Inhibits Growth of the Human Pathogens Trypanosoma brucei and Plasmodium falciparum

“…To our knowledge, in addition to our study and that of Spavieri, there is no data available regarding the antiprotozoal properties of extracts derived from this species. In contrast, cytotoxic activities have been described for methanolic and chloroform/methanol extracts and compounds isolated from ether extracts of B. bifurcata [12,13,14]. …”