An extension of unpredictable chronic stress on brain-derived neurotrophic factor expression in different aged rats hippocampus

Zhou, Li; Peng, Feng-Lin

doi:10.1097/cm9.0000000000000961

Cited by 1 publication

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“…Clinical observations of the normal sleep-wake cycle showed that proinfammatory cytokines increase in early sleep and that there is an increase in immune cells and anti-infammatory cytokines during the daytime [19]. Moreover, immune function is signifcantly decreased in patients with generalized anxiety with sleep disorder compared to those with generalized anxiety and no sleep disorder [20]. Te reason for this may be that insomnia, as a chronic stress, has a signifcant impact on the brain function and nervous system of the body, leading to dysfunction of 5-HT, which afects the homeostasis of the body.…”

Section: Discussionmentioning

confidence: 99%

Linear Regression Analysis of Sleep Quality in People with Insomnia in Wuhan City during the COVID-19 Pandemic

Jin

Wang

Zhang

et al. 2023

International Journal of Clinical Practice

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Objective. COVID-19 has evolved into a major global public health event. The number of people reporting insomnia is growing exponentially during the pandemic. This study aimed to explore the relationship between aggravated insomnia and COVID-19-induced psychological impact on the public, lifestyle changes, and anxiety about the future. Methods. In this cross-sectional study, we used the questionnaires from 400 subjects who were obtained from the Department of Encephalopathy of the Wuhan Hospital of Traditional Chinese Medicine between July 2020 and July 2021. The data collected for the study included demographic characteristics of the participants and psychological scales consisting of the Spiegel Sleep Questionnaire, the Fear of COVID-19 Scale (FCV-19S), the Zung Self-Rating Anxiety Scale (SAS), and the Zung Self-Rating Depression Scale (SDS). The independent sample t-test and one-way ANOVA were used to compare the results. Correlation analysis of variables affecting insomnia was performed using Pearson correlation analysis. The degree of influence of the variables on insomnia was determined using linear regression, and a regression equation was derived. Results. A total of 400 insomnia patients participated in the survey. The median age was 45.75 ± 15.04 years. The average score of the Spiegel Sleep Questionnaire was 17.29 ± 6.36, that of SAS was 52.47 ± 10.39, that of SDS was 65.89 ± 8.72, and that of FCV-19S was 16.09 ± 6.81. The scores of FCV-19S, SAS, and SDS were closely related to insomnia, and the influencing degree was in the following order: fear, depression, and anxiety (OR = 1.30, 0.709, and 0.63, respectively). Conclusion. Fear of COVID-19 can be one of the primary contributors to worsening insomnia.

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Section: Discussionmentioning

confidence: 99%