1988
DOI: 10.1073/pnas.85.1.222
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An extended HLA-D region haplotype associated with celiac disease.

Abstract: Celiac disease has one of the strongest associations with HLA (human leukocyte antigen) class H markers of the known HLA-linked diseases. This association is primarily with the class II serologic specificities HLA-DR3 and -DQw2. We previously described a restriction fragment length polymorphism (RFLP) characterized by the presence of a 4.0-kilobase Rsa I fragment derived from an HLA class II

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Cited by 53 publications
(27 citation statements)
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References 29 publications
(28 reference statements)
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“…Several reports have recently indicated an association between CD and certain genomic DP polymorphisms (18,19). At present it is not clear whether both DQ and DP genes might contribute to susceptibility to CD or whether the DP associations are secondary to the DQ association.…”
Section: Resultsmentioning
confidence: 98%
“…Several reports have recently indicated an association between CD and certain genomic DP polymorphisms (18,19). At present it is not clear whether both DQ and DP genes might contribute to susceptibility to CD or whether the DP associations are secondary to the DQ association.…”
Section: Resultsmentioning
confidence: 98%
“…It is conceivable that in the genetieally predisposed individual the onset ofthe disease may require some other genetie or environmental factors, such as an extended haplotype involving the DP locus (Howell et al, 1988;Bugawan e;Kagnoffe/a/., 1989;Colonnae/a/., 1990) and other hypothetical polymorphic loci (Weiss et al, 1983) or adenovirus infection (Kagnoff e;.…”
Section: Resultsmentioning
confidence: 99%
“…1. CD patients in the USA and England showed a very high incidence of certain alphaDP and betaDP chain alleles (Howell et al, 1988;Niven et aI., 1987); the most common allele in the USA was DPB I *030 I followed by DPB I *0402 and by DPB I *0 IO 1 (Kagnoff et al, 1989), while in a Caucasian English population an increase of DPB 1 *0 10 I was observed (Rosemberg et aI., 1989). The same RFLPs did not reveal any significant DP association in an Argentinian population (Herrera et al, 1989).…”
Section: Discussionmentioning
confidence: 99%
“…, 1988). and DPB I alleles defined by restriction fragment length polymorphism (RFLP) analysis (Howell et al , 1988;Niven et aI. , 1987) or by probing polymerase chain reaction amplified genomic DNA, with sequence specific oligonucleotides (Bugawan et ai., 1989;Roep et al, 1988;Howell et aI., 1988;Niven et aI.…”
Section: Introductionmentioning
confidence: 99%