Distribution of HLA‐DPBl, ‐DQBI‐DQAl Alleles among Sardinian Celiac Patients

Boy, M. F.; Nasa, Giorgio La; Balestrieri, A; Cherchi, Maria Valeria; Usai, Paolo

doi:10.1155/1994/629152

Cited by 8 publications

(4 citation statements)

References 5 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The distribution of DQB1 alleles in our study was in agreement with the most frequent genotypes among Sardinian CD patients [31]. The observed homozygosity for DQB1 0201 amounts to 38% of the cases, and all of the patients showed at least one DQB1 0201 allele.…”

Section: Discussionsupporting

confidence: 88%

“…In Italy, [30] 98% and 51% of CD patients showed DQB1 0201 and DQB1 0301 alleles, respectively, followed, in decreasing frequency, by DQB1 0302, DQB1 06*, and DQB1 05*. No significant differences were found between allele distribution in Aragonese CD children and Italian CD children or Sardinian CD cases, respectively as studied by Boy et al [31] in 1994.…”

Section: Discussionmentioning

confidence: 85%

See 1 more Smart Citation

Study of HLA-DQB1 alleles in Spanish celiac patients and their first-degree relatives

Ruiz

Olivares

2001

Gene Funct. Dis.

View full text Add to dashboard Cite

Celiac disease (CD) susceptibility is strongly associated with the HLA alleles DQA1 0501 Blesa" University of Zaragoza Medical and DQB1 02*. To investigate this, we performed a study which included thirty celiac School, Zaragoza, Spain children and sixty-five first-degree relatives of them. DQB1 genotyping was performed by PCR (polymerase chain reaction) amplification. The allele frequencies in each group were compared by Chi-square test (χ 2 ) using Yates correction and Fisher test. Most patients (70%) were positive for DQB1 0201. HLA-DQB1 0201 was found in 61% of the first-degree relatives. 58% of the patients showed heterozygosity for DQB1 0201, whereas 12% of the celiac patients were homozygous for DQB1 0201. These findings support the role of DQB1 0201 alleles as a risk factor for celiac disease. No significant differences could be detected in the HLA-DQB1 allele distribution between celiac patients and their first-degree relatives.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 85%

Study of HLA-DQB1 alleles in Spanish celiac patients and their first-degree relatives

Ruiz

Olivares

2001

Gene Funct. Dis.

View full text Add to dashboard Cite

show abstract

“…Finally, CD patients are nowadays exposed to nutritional imbalances by assuming foods that are high in sugars, fats, and calories, or rich in proteins, like eggs and meat, in addition to snacks with a high content of lipids and low fibers [18,19], which may additionally lead to irritable bowel syndrome-like symptoms [20]. Indeed, the majority of gluten-free commercial grain-based products contain less fiber than their gluten-containing equivalents so patients may report weight gain and constipation [21]. GFD induces microbial shifts with possible consequent impairment of the immune-metabolic homeostasis, which may contribute to functional symptoms' persistence.…”

Section: Impact Of the Gluten-free Diet On The Microbiomementioning

confidence: 99%

Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients

et al. 2020

View full text Add to dashboard Cite

To date, the only available treatment for celiac disease (CD) patients is a life-lasting gluten-free diet (GFD). Lack of adherence to the GFD leads to a significant risk of adverse health consequences. Food cross-contamination, nutritional imbalances, and persistent gastrointestinal symptoms are the main concerns related to GFD. Moreover, despite rigid compliance to GFD, patients struggle in achieving a full restoring of the gut microbiota, which plays a role in the nutritive compounds processing, and absorption. Pivotal studies on the supplementation of GFD with probiotics, such as Bifidobacterium and Lactobacilli, reported a potential to restore gut microbiota composition and to pre-digest gluten in the intestinal lumen, reducing the inflammation associated with gluten intake, the intestinal permeability, and the cytokine and antibody production. These findings could explain an improvement in symptoms and quality of life in patients treated with GFD and probiotics. On the other hand, the inclusion of prebiotics in GFD could also be easy to administer and cost-effective as an adjunctive treatment for CD, having the power to stimulate the growth of potentially health-promoting bacteria strains. However, evidence regarding the use of prebiotics and probiotics in patients with CD is still insufficient to justify their use in clinical practice.

show abstract

“…CD shares many features with autoimmune disorders in general, such as a polygenic mode of inheritance, a strong association with HLA-DQ2 and HLA-DQ8 antigens, the production of a local inflammatory response (lymphocyte infiltration and cytokine production), the presence of autoantibodies in the circulation, female preponderance, and an association with other autoimmune diseases (1,2,11,14,19,30,33,88,91,92,97,104). There is a strong association of CD with HLA class II molecules with Ͼ90% of CD patients having the HLA-DQ ‫,1050ء1␣‬ ‫1020ء1␤‬ heterodimer (19,88,91,92,117).…”

Section: CDmentioning

confidence: 99%

Celiac Disease-Associated Autoimmune Endocrinopathies

Kumar

Rajadhyaksha

Wortsman

2001

Clin Diagn Lab Immunol

View full text Add to dashboard Cite

3Celiac disease (CD) is an autoimmune disorder induced by gluten intake in genetically susceptible individuals. It is characterized by the presence of serum antibodies to endomysium, reticulin, gliadin, and tissue transglutaminase. The incidence of CD in various autoimmune disorders is increased 10-to 30-fold in comparison to the general population, although in many cases CD is clinically asymptomatic or silent. The identification of such cases with CD is important since it may help in the control of type I diabetes or endocrine functions in general, as well as in the prevention of long-term complications of CD, such as lymphoma. It is believed that CD may predispose an individual to other autoimmune disorders such as type I diabetes, autoimmune thyroid, and other endocrine diseases and that gluten may be a possible trigger. The onset of type I diabetes at an early age in patients with CD, compared to non-CD, and the prevention or delay in onset of diabetes by gluten-free diet in genetically predisposed individuals substantiates this antigen trigger hypothesis. Early identification of CD patients in highly susceptible population may result in the treatment of subclinical CD and improved control of associated disorders.Autoimmunity as a concept evolved from the beginning of this century, when Ehrlich and Morgenroth (26) introduced the phenomenon of "horror autotoxicus," i.e., fear of selfpoisoning. Subsequently, many diseases were recognized with etiology arising from the abnormal reaction of the immune system to self antigens. These observations laid the foundation for establishing postulates that are characteristic of an autoimmune disease (4, 7). Since then, several hypotheses have been put forward regarding the mechanisms of autoimmunity (22,76,84,110,118).In general, autoimmune disorders can be classified as either organ specific or non-organ specific. In organ-specific autoimmune diseases, the autoantibodies are specifically directed against antigens localized in a particular organ and are often detected in circulation. Examples of organ-specific autoimmunity include Hashimoto's thyroiditis, type I diabetes, and myasthenia gravis.In contrast, the non-organ-specific autoimmune disorders are characterized by the presence of autoantibodies directed against ubiquitous antigens (not specific to a particular organ). This results in the involvement of several organs and is often characterized by the presence of specific circulating immune complexes. Non-organ-specific autoimmunity includes diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and scleroderma.Epidemiologic studies have shown that genetic factors are involved in host susceptibility to autoimmune disease. For example, the concordance rate of a particular autoimmune diseases is much higher in monozygotic twins in comparison to fraternal twins (17). Moreover, this incidence is much higher in organ-specific autoimmune disorders in comparison to nonorgan-specific disorders. Thus, in Grave's thyrotoxicosis, Hashimoto's disease, a...

show abstract

Distribution of HLA‐DPBl, ‐DQBI‐DQAl Alleles among Sardinian Celiac Patients

Cited by 8 publications

References 5 publications

Study of HLA-DQB1 alleles in Spanish celiac patients and their first-degree relatives

Study of HLA-DQB1 alleles in Spanish celiac patients and their first-degree relatives

Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients

Celiac Disease-Associated Autoimmune Endocrinopathies

Contact Info

Product

Resources

About