An exploratory transmission mode of HIV/AIDS among older people based on data from multiple sources in China

Sun, Xiaowei; Feng, Caibi; Feng, Liao; Xiao, Ticheng; Zhao, Xinran; Liu, Hong; Wang, Zhiqiu; Chen, Chen; Zhou, Shoulin; Zhou, Dongxu

doi:10.1038/s41598-022-20146-2

Cited by 7 publications

(4 citation statements)

References 36 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Older people (aged ≥ 50 years) were more likely to form clusters in the transmission network (50%, 199/398), and high-risk linkages (72.0%, 113/157) and individuals who carried the resistance mutation, K103N (87.5%, 56/64), were part of the largest CRF07_BC cluster (LC1). Elderly men, especially younger ones, still have psychological and physical needs [21] . Most male (94.4%, 85/90) individuals in the four LCs self-reported nonmarital heterosexual sexual contact.…”

Section: Discussionmentioning

confidence: 99%

“…High-density and continuous cross-sectional sampling for molecular epidemiological analysis revealed that older people play an important role in the transmission of speci c subtypes and high pretreatment drug resistance (PDR) in Shaoxing city from 2019 to 2023. The ageing of individuals affected by the HIV epidemic in China [10] is particularly signi cant in Shaoxing. This high proportion of sampling could re ect the characteristics of HIV-1 transmission in Shaoxing more comprehensively and reduce deviation and insu ciency.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Molecular transmission network analysis reveals the challenge of HIV-1 in ageing patients in China: elderly people play a crucial role in the transmission of subtypes and high pretreatment drug resistance in developed Eastern China, 2019-2023

Cao,

Xing,

Feng

et al. 2024

Preprint

View full text Add to dashboard Cite

Background The number and proportion of HIV/AIDS patients among older people are continuously and rapidly increasing in China. We conducted a detailed molecular epidemiological analysis of HIV-1 epidemic strains in a developed city in eastern China and found that elderly people play a crucial role in the transmission of subtypes and high pretreatment drug resistance (PDR). Methods A total of 1048 samples were obtained from 1129 (92.8%) newly confirmed HIV-1-positive and treatment-naive patients between 2019 and 2023. The 1316 bp target fragment of the pol gene was amplified by reverse transcription polymerase chain reaction (RT‒PCR) and nested PCR, and a phylogenetic tree and molecular transmission network were constructed to analyse the subtypes and transmission clusters. PDR-associated mutations were determined according to the Stanford University HIV Drug Resistance Database. Results A total of 933 pol sequences (91.23%, 933/1048) were successfully obtained, and twelve HIV-1 subtypes were detected. CRF07_BC was the predominant subtype, accounting for 48.1% (449/933) of sequences, followed by CRF01_AE (29.37%, 274/933). A total of 398 individuals (42.7%, 398/933) formed 89 clusters in the network. Multivariable logistic regression analysis revealed that age, nationality, subtype, and PDR were the most significant factors associated with clustering in the transmission network. The prevalence of PDR was 14.6% (136/933).PDR associated with non-nucleoside reverse transcriptase inhibitors (10.0%, 93/933) was much more common than that associated with nucleoside reverse transcriptase inhibitors (1.8%, 17/933) and protease inhibitors (3.2%, 30/933) (2 = 77.961, p < 0.001). The most frequent NNRTI mutations were K103N/S/KN/NS (52.2%, 71/136), which caused the highest proportion of high-level resistance to nevirapine and efavirenz (52.2%). Conclusions Our study revealed the important influence of elderly people on CRF07_BC transmission and the high prevalence of PDR. The clustering of drug-resistant cases was significant, which suggested the potential for localized widespread transmission of drug-resistant strains. HIV screening and the determination of PDR are recommended for older patients to improve early detection and reduce treatment failure and second-generation transmission.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Molecular transmission network analysis reveals the challenge of HIV-1 in ageing patients in China: elderly people play a crucial role in the transmission of subtypes and high pretreatment drug resistance in developed Eastern China, 2019-2023

Cao,

Xing,

Feng

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…New challenge need to paid significant attention. Shortage of sexual education in university students in China, was results in unoptimistic problem on their sexual health [ 29 , 30 ]. Innovative and optimized prevention and treatment methods in HIV/AIDS should be provided through internet communities, including preexposure and postexposure prophylaxis and self-testing services.…”

Section: Discussionmentioning

confidence: 99%

Correlates of condom use among male university students from eastern China who engage in casual sex

Chen

Zhou

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Consistent condom use with casual partners is critical for preventing the transmission of human immunodeficiency virus (HIV) among male university students. This study aimed to determine the level of consistent condom use and explore the correlates of condom use consistency in male university students in eastern China. A descriptive cross-sectional survey was conducted in 13 universities in Zhejiang Province, which involved the recruitment of 31,674 students by stratified random sampling. Among them, 545 male students who engaged in casual sex in the year prior to this study were included. Adjusted and unadjusted logistic regression models were used to examine the correlates associated with consistent condom use. Among the 545 male university students, only 205 (37.6%) consistently used condoms in the previous year. The following correlates were associated with higher rates of consistent condom use: 1) Knowledge, specifically, the number of correct answers to “HIV infection can be determined by appearance” (AOR: 2.06, 95% CI: 1.21–3.49); 2) never finding casual partners on the internet during the past over the prior year (AOR: 0.63; 95% CI: 0.40–0.99); 3) never drinking alcohol before casual sex during the last over the prior year (AOR: 0.30; 95% CI: 0.20–0.46); 4) never engaging in commercial sex (AOR: 0.57; 95% CI: 0.34–0.96); and 5) high condom self-efficacy score (AOR: 2.55; 95% CI: 1.44–4.49). The study found a low level of consistent condom use among male university students. Promoting condom self-efficacy, reducing web-based casual sex, drinking before sex, and commercial sex are essential to improving the level of consistent condom use among male university students to reduce the transmission of HIV.

show abstract

“…3 In many countries, new HIV infections among older adults are increasing 4,5 including the Asia-Pacific region. 6,7 Acquiring HIV at an older age has also been associated with higher morbidity and mortality compared to younger adults. 8,9 The exact reasons for their poorer prognosis especially in the current treat-all era is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Causes, risks and care circumstances associated with death in older adults diagnosed with HIV in a tertiary centre in Malaysia

Wong,

Pui Li,

Abdul Kahar

et al. 2024

Int J STD AIDS

View full text Add to dashboard Cite

Background A substantial number of older adults succumb soon after HIV diagnosis despite ART. We explored the causes, risk factors and circumstances before death among older adults acquring HIV. Methods We recruited individuals newly diagnosed at our centre from 2016-2020 and analysed data of those who died. Patients were stratified to older (≥50 years) or younger (<50 years) based on their age at diagnosis and attributes were compared. The Cox proportional multivariable model was used to identify factors associated with all-cause mortality. Results Among 75 deaths reported, the majority of deaths were AIDS-related and late presentation was common in both age groups. The majority of deaths occurred in the first 12 months after care presentation and over two-thirds in both groups disengaged from care prior to death. Older age remained an independent factor associated with death after adjusting for confounders including opportunistic infections, late presentation to care, ART initiation and chronic comorbidities at presentation. Conclusion Most causes of death in our setting were AIDS-related and associated with late care presentation both in young and older individuals, although older age at diagnosis remained an independent risk factor. Our findings highlight the urgent need to encourage prompt ART initiation following diagnosis, especially in older adults.

show abstract

An exploratory transmission mode of HIV/AIDS among older people based on data from multiple sources in China

Cited by 7 publications

References 36 publications

Molecular transmission network analysis reveals the challenge of HIV-1 in ageing patients in China: elderly people play a crucial role in the transmission of subtypes and high pretreatment drug resistance in developed Eastern China, 2019-2023

Molecular transmission network analysis reveals the challenge of HIV-1 in ageing patients in China: elderly people play a crucial role in the transmission of subtypes and high pretreatment drug resistance in developed Eastern China, 2019-2023

Correlates of condom use among male university students from eastern China who engage in casual sex

Causes, risks and care circumstances associated with death in older adults diagnosed with HIV in a tertiary centre in Malaysia

Contact Info

Product

Resources

About