An Exploratory Study on the Uses of "Wrong" Simulation Models in Practice

Tsioptsias, Naoum; Tako, Antuela A.; Robinson, Stewart

doi:10.36819/sw21.018

Cited by 3 publications

(3 citation statements)

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“…Model validation is the key aspect of the model design and development process 24. The final purpose of the validation process is to ensure that the model produced is reasonably dependable for the current cause 25.…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics-Pharmacodynamics Modeling and Evaluation of Tumor Response to Bortezomib Proteasome Inhibitor in Waldenstrom Macroglobulinemia

Munir¹,

Fazal²,

Bhatti³

et al. 2023

American Journal of Clinical Oncology

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Background: Waldenstrom's macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a type of non-Hodgkin's lymphoma in which the malignant cells produce many macroglobulin proteins. It originates from B cells and develops in the bone marrow, where Wm cells combine to produce distinct types of blood cells, resulting in reduced volumes of red blood cells, white blood cells, and platelets, making it harder for the body to fight diseases. Chemoimmunotherapy is being used for the clinical management of WM, but new targeted agents, the BTK inhibitor ibrutinib and the proteasome inhibitor bortezomib, have shown significant improvements in patients with relapsed/refractory WM. However, given its effectiveness, drug resistance and relapse are normal, and there is little research on the pathways responsible for drug effects on the tumor.Methods: In this study, Pharmacokinetics-pharmacodynamic simulations were done to assess the effect of the proteasome inhibitor bortezomib on the tumor. For this purpose, the Pharmacokineticspharmacodynamic model was developed. The model parameters were determined and calculated using the Ordinary Differential Equation solver toolbox and the least-squares function. Pharmacokinetic profiles and pharmacodynamic analysis were performed to determine the change in tumor weight associated with the use of proteasome inhibitors.Results: Bortezomib and ixazomib have been found to reduce tumor weight briefly, but once the dose is reduced, the tumor begins to grow again. Carfilzomib and oprozomib had better results, and rituximab reduced tumor weight more effectively. Conclusion:Once validated, it is proposed that a combination of selected drugs can be evaluated in the laboratory to treat WM.

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Section: Methodsmentioning

confidence: 99%

Pharmacokinetics-Pharmacodynamics Modeling and Evaluation of Tumor Response to Bortezomib Proteasome Inhibitor in Waldenstrom Macroglobulinemia

Munir¹,

Fazal²,

Bhatti³

et al. 2023

American Journal of Clinical Oncology

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“…This step's primary goal is to validate and test the selected model for the data in the model development process. The validation procedure is used to ensure that the developed model is accurate enough for the intended use [68]. The first half of this step, model validation, is important because the used/newly developed model cannot be relied on solely because it was designed to fit the training data and demonstrates that the training data fits the model well.…”

Section: Data Model Validation and Testingmentioning

confidence: 99%

Artificial Intelligence-Based Medical Data Mining

Zia¹,

Aziz

Popa³

et al. 2022

JPM

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Understanding published unstructured textual data using traditional text mining approaches and tools is becoming a challenging issue due to the rapid increase in electronic open-source publications. The application of data mining techniques in the medical sciences is an emerging trend; however, traditional text-mining approaches are insufficient to cope with the current upsurge in the volume of published data. Therefore, artificial intelligence-based text mining tools are being developed and used to process large volumes of data and to explore the hidden features and correlations in the data. This review provides a clear-cut and insightful understanding of how artificial intelligence-based data-mining technology is being used to analyze medical data. We also describe a standard process of data mining based on CRISP-DM (Cross-Industry Standard Process for Data Mining) and the most common tools/libraries available for each step of medical data mining.

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“…Specifically, the results from the CCTV footage analysis (in the initial layout) were compared with the results from the simulation analysis (in the initial layout). It was found that the deviation between the results was less than 2% and that was presented to the managers of the company (who are the decision-makers) in order to accept or reject the model (Tsioptsias et al, 2016). They accepted the deviation and the simulation model and they concluded that the model behaves in a reasonable manner.…”

Section: Verification and Validationmentioning

confidence: 99%