An Exploratory study of profile of Multidrug resistant Tuberculosis cases of Kashmir valley

Ayub, Taha

doi:10.18535/jmscr/v5i7.209

Cited by 3 publications

(7 citation statements)

References 5 publications

(8 reference statements)

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“… 7 , 23 , 27 , 28 In the current study, environmental and physical domains were the most affected domains in RR/MDR-TB and DS-TB patients, respectively. This is contrary to a finding which stated environmental domain as the least affected domain 29 but similar to the results of two studies conducted among DS-TB patients. 30 , 31 Although TB diagnosis, management and related hospital admissions were provided free of charge to all TB patients, and RR/MDR-TB patients were also offered monthly pocket money for the duration of the treatment, participants of the present study reported that they lacked money to cover their daily needs and felt unsafe in their everyday life.…”

Section: Discussionsupporting

confidence: 67%

“…This finding is consistent with a study that reported the psychological domain as the least affected one, 39 but contrary to several studies that reported the opposite. 29 , 35 , 40 Although more than half of our study participants reported that they had negative feelings and were not satisfied with themselves, they felt and viewed their life as meaningful and were able to accept their bodily appearance. The possible reason for the relatively higher mean score in this domain than in other domains cannot be directly speculated.…”

Section: Discussionmentioning

confidence: 87%

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Health-Related Quality of Life in Tuberculosis Patients in Eritrea: Comparison Among Drug-Susceptible and Rifampicin/Multidrug-Resistant Tuberculosis Patients

Araia¹,

Berhane²,

Mebrahtu³

et al. 2021

PROM

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Background Despite the negative impact of tuberculosis (TB) on patients’ quality of life, TB control programs focus on biological and clinical parameters to manage and monitor TB patients. In our setting, patients’ perception of their experience with TB and the impacts of TB on patients’ physical, mental, and social wellbeing remain unknown. Objective The objective of this study was to evaluate the health-related quality of life (HRQOL) among rifampicin/multidrug-resistant TB (RR/MDR-TB) in comparison to drug-susceptible TB (DS-TB) patients in Eritrea. Methods A cross-sectional study was conducted in RR/MDR-TB and DS-TB patients under treatment. Anonymized data collected using the WHOQOL-BREF questionnaire were analyzed using SPSS version 23. Frequency, mean and standard deviation were used to describe the data. Mean group score comparison and relationship between variables were assessed using t -test. Domain score was calculated with a mean score of items within each domain and scaled positively, a higher (increasing) score denoting a higher quality of life. Internal consistency was measured using Cronbach’s alpha and statistical significance was set at p < 0.05. Results A total of 92 patients (46 RR/MDR-TB and 46 DS-TB) participated in the study. Environmental (40.63 ± 10.72) and physical domains (61.80 ±17.18) were the two most affected domains in RR/MDR-TB and DS-TB patients, respectively. The psychological domain was the least affected domain in RR/MDR-TB (48.28 ± 20.83) and DS-TB patients (76.63 ±15.32). RR/MDR-TB patients had statistically lower mean scores in all domains than DS-TB patients. Conclusion HRQOL was impaired in both groups, but RR/MDR-TB patients had a worse health-related quality of life.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 87%

Health-Related Quality of Life in Tuberculosis Patients in Eritrea: Comparison Among Drug-Susceptible and Rifampicin/Multidrug-Resistant Tuberculosis Patients

Araia¹,

Berhane²,

Mebrahtu³

et al. 2021

PROM

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“…In the present study, transformed-median domain scores in physical (39.3 vs. 53.6 vs. 89.3) and psychological (50.0 vs. 54.2 vs. 87.5) domains were significantly lower among MDRTB cases as compared to non MDRTB cases and TB cured subjects respectively, which is similar to several other studies. [6][7][8][9][10] The impact of the disease on physical functioning was in the form of easy fatigability, regular body ache, and lack of sleep, unrest and decreased working capacity. There were reports regarding restrictions towards their freedom of movement, participation in home and day to day recreation/leisure activities.…”

Section: Discussionmentioning

confidence: 99%

Quality of life among patients on MDR-TB treatment in a district tuberculosis centre of a metropolitan city

Patel

Lalitha

Rajaram

et al. 2018

Int J Community Med Public Health

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Background: MDRTB is a global health concern with its current prevalence in India being 2.3% and 17.2% respectively among newly diagnosed and previously treated cases. Besides its clinical impact, the disease affects the QOL of patients suffering from MDR-TB. The objective of the study was to assess the quality of life among MDR-TB cases in comparison with non-MDR TB cases and TB cured subjects (Category I, RNTCP).Methods: A cross sectional study was conducted in all the 14 TUs under District Tuberculosis Centre of Municipal Corporation of Bengaluru (BBMP). Study subjects comprised of 52 MDR-TB Cases, 53 Non-MDR-TB cases and 54 Category I TB cured subjects. WHOQOL BREF questionnaire was used to assess the QOL among study subjects. Median [IQR] scores of QOL in each of the domains among various groups were compared using Kruskal Wallis test. P<0.05 was considered as statistically significant.Results: Median age among MDRTB cases was 35 years [IQR: 26-50] whereas it was 37 years [IQR: 28-47] among Non MDRTB cases and 30.5 years [IQR: 22-45] among TB cured subjects. Out of 52 MDRTB cases, 26(50%) were females compared to 14 (26.4%) among Non MDRTB cases and 26(48.1%) among TB cured subjects (p=0.0024). As compared to non MDRTB cases, physical and environmental domains’ scores of MDRTB cases were significantly low (p=0.01 and p=0.001 respectively).Whereas, as compared to TB cured subjects, physical and psychological domains’ scores of MDRTB cases were significantly low (p<0.001 and p<0.001 respectively).Conclusions: The QOL of patients suffering from TB is affected and the impact is even worse in MDRTB. Hence prompt treatment of TB and early diagnosis of MDRTB will reduce the disease severity and improve the QOL.

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“…Similar age groups were affected by DR-TB in previous studies. [8][9][10][11] 78% participants were married. Similar finding was seen in other studies.…”

Section: Fig 3: Hrqol Mean Domain Scores (N=172)mentioning

confidence: 99%

“…Similar finding was seen in other studies. [8][9][10] DR-TB interfered with sexual relationship of married couples as they lost interest in sex due to their illness and weakness. So social relationship domain was affected in large number of participants.…”

Section: Fig 3: Hrqol Mean Domain Scores (N=172)mentioning

confidence: 99%

Assessment of health related quality of life of drug resistant tuberculosis patients

2020

IJPP

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Assessment of Health Related Quality of Life (HRQoL) of drug resistant tuberculosis patients at the start of treatment under PMDT regime. Materials and Methods: This observational study was conducted on a cohort of 172 drug resistant tuberculosis (DR-TB) patients at the time of registration under PMDT regime. Patients who started their treatment between January 2016 and December 2016 were included in the study after approval from IEC. A validated WHOQOL-BREF questionnaire was used for interviewing the patients. This questionnaire assesses HRQoL on 0-100 transforming scale in four domains -Physical, Psychological, Social relationship and Environmental. Results: Out of 172 participants, 50 (29.1%) were females and 122(70.9%) were males. Their mean ageSD was 40.2315.77 years. 77.9% participants were married. 97.7% of them were residing in rural areas. Most of the participants were from district Mandi (33.1%) and Kangra (20.9%). Scores of Physical domain were 39.7613.88; Psychological domain were 37.2314.89; Social relationship domain were 43.2813.48 and Environment domain were 50.669.13. Overall HRQoL scores were 42.7310.11. Conclusion: Chronic diseases like tuberculosis affect all domains of HRQoL and there is need to consider HRQoL domains of patients of DR-TB along with smear positivity and mortality to evaluate the success of any national heath programme.

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An Exploratory study of profile of Multidrug resistant Tuberculosis cases of Kashmir valley

Cited by 3 publications

References 5 publications

Health-Related Quality of Life in Tuberculosis Patients in Eritrea: Comparison Among Drug-Susceptible and Rifampicin/Multidrug-Resistant Tuberculosis Patients

Health-Related Quality of Life in Tuberculosis Patients in Eritrea: Comparison Among Drug-Susceptible and Rifampicin/Multidrug-Resistant Tuberculosis Patients

Quality of life among patients on MDR-TB treatment in a district tuberculosis centre of a metropolitan city

Assessment of health related quality of life of drug resistant tuberculosis patients

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