An Explanation for the Adiponectin Paradox

Kalkman, Hans O.

doi:10.3390/ph14121266

Cited by 21 publications

(19 citation statements)

References 86 publications

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“…Not all adipokines stimulate tumor growth; in fact, adiponectin (Acrp30) is an important adipokine with anti-inflammatory and beneficial metabolic effects, and is a protein hormone with 244 amino acids that signals through three distinct receptors, AdipoR1 and AdipoR2 (expressed in several organs, tissues, and cell lines) and a third receptor protein, T-cadherin (a receptor mainly expressed in the vascular system). Acrp30 exists as oligomers with low (LMW), medium (MMW), and high molecular weights (HMW), the latter form having the most important biological effects [77]. Several datasets support the hypothesis of both direct and indirect roles for Acrp30 as a regulatory mediator of various mechanisms underlying lung carcinogenesis.…”

Section: Adiponectin and Lung Cancermentioning

confidence: 85%

The Potential Role of Nutrition in Lung Cancer Establishment and Progression

Porro

Torre

Tartaglia

et al. 2022

Life

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Lung cancer is a devastating disease with a high incidence and low survival rates, so recent studies have focused on analyzing the risk factors that might prevent this disease from developing or have protective/therapeutic effects. Nutrition is an important key factor in the prevention and treatment of lung cancer. Various factors appear to be involved in the development of the latter, such as cigarette smoking or certain external environmental factors. The increase in oxidative stress is therefore an integral part of the carcinogenesis process. The biological role of bioactive factors derived from adipose tissue, mainly adipokines, is implicated in various cancers, and an increasing body of evidence has shown that certain adipocytokines contribute to the development, progression and prognosis of lung cancer. Not all adipokines stimulate tumor growth; in fact, adiponectin inhibits carcinogenesis by regulating both cell growth and the levels of inflammatory cytokines. Adiponectin expression is deregulated in several cancer types. Many nutritional factors have been shown to increase adiponectin levels and therefore could be used as a new therapeutic strategy for combating lung cancer. In addition, foods with antioxidant and anti-inflammatory properties play a key role in the prevention of many human diseases, including lung cancer. The purpose of this review is to analyze the role of diet in lung cancer in order to recommend dietary habit and lifestyle changes to prevent or treat this pathology.

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Section: Adiponectin and Lung Cancermentioning

confidence: 85%

The Potential Role of Nutrition in Lung Cancer Establishment and Progression

Porro

Torre

Tartaglia

et al. 2022

Life

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“…Noteworthy, when our manuscript was close to its final layout, a new plausible explanation for 'adiponectin parodox' was proposed by Hans O. Kalkman in his review article in December 2021 issue of Pharmaceuticals [233]. [97], any dysfunction in the system can further aggravate impaired signaling, including the insulin resistance.…”

Section: Facets Of Adiponectin Paradoxmentioning

confidence: 88%

“…[97], any dysfunction in the system can further aggravate impaired signaling, including the insulin resistance. In such circumstances metformin, acting on adiponectin pathway and inducing AMPK activation downstream of adiponectin receptors, can be a therapy of choice [233].…”

Section: Facets Of Adiponectin Paradoxmentioning

confidence: 99%

Adiponectin: a pleiotropic hormone with multifaceted roles

Shklyaev

Мельниченко

Волеводз

et al. 2021

Probl Endokrinol (Mosk)

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Adipose tissue mostly composed of different types of fat is one of the largest endocrine organs in the body playing multiple intricate roles including but not limited to energy storage, metabolic homeostasis, generation of heat, participation in immune functions and secretion of a number of biologically active factors known as adipokines. The most abundant of them is adiponectin. This adipocite-derived hormone exerts pleiotropic actions and exhibits insulin-sensitizing, antidiabetic, anti-obesogenic, anti-inflammatory, antiatherogenic, cardio- and neuroprotective properties. Contrariwise to its protective effects against various pathological events in different cell types, adiponectin may have links to several systemic diseases and malignances. Reduction in adiponectin levels has an implication in COVID-19-associated respiratory failure, which is attributed mainly to a phenomenon called ‘adiponectin paradox’. Ample evidence about multiple functions of adiponectin in the body was obtained from animal, mostly rodent studies. Our succinct review is entirely about multifaceted roles of adiponectin and mechanisms of its action in different physiological and pathological states.

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“…On the other hand, different studies have observed that high levels of this adipokine are associated with a higher risk of death, including CVR. Hence, it is sometimes called the “adiponectin paradox” [ 109 ]. Menon et al showed that an increase in serum adiponectin among stages 3–4 of CKD by 1 µg/mL was associated with a 6% higher CVR [ 110 ].…”

Section: Adipokines and Their Influence On Pathogenesis Nutritional D...mentioning

confidence: 99%

Pro-Inflammatory Profile of Adipokines in Obesity Contributes to Pathogenesis, Nutritional Disorders, and Cardiovascular Risk in Chronic Kidney Disease

et al. 2022

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Obesity is a disease which leads to the development of many other disorders. Excessive accumulation of lipids in adipose tissue (AT) leads to metabolic changes, including hypertrophy of adipocytes, macrophage migration, changes in the composition of immune cells, and impaired secretion of adipokines. Adipokines are cytokines produced by AT and greatly influence human health. Obesity and the pro-inflammatory profile of adipokines lead to the development of chronic kidney disease (CKD) through different mechanisms. In obesity and adipokine profile, there are gender differences that characterize the male gender as more susceptible to metabolic disorders accompanying obesity, including impaired renal function. The relationship between impaired adipokine secretion and renal disease is two-sided. In the developed CKD, the concentration of adipokines in the serum is additionally disturbed due to their insufficient excretion by the excretory system caused by renal pathology. Increased levels of adipokines affect the nutritional status and cardiovascular risk (CVR) of patients with CKD. This article aims to systematize the current knowledge on the influence of obesity, AT, and adipokine secretion disorders on the pathogenesis of CKD and their influence on nutritional status and CVR in patients with CKD.

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An Explanation for the Adiponectin Paradox

Cited by 21 publications

References 86 publications

The Potential Role of Nutrition in Lung Cancer Establishment and Progression

The Potential Role of Nutrition in Lung Cancer Establishment and Progression

Adiponectin: a pleiotropic hormone with multifaceted roles

Pro-Inflammatory Profile of Adipokines in Obesity Contributes to Pathogenesis, Nutritional Disorders, and Cardiovascular Risk in Chronic Kidney Disease

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