An experimental study of the effect of isoflurane on epileptiform bursts

Langmoen, Iver A.; Hegstad, Elisabeth; Berg-Johnsen, Jon

doi:10.1016/0920-1211(92)90093-9

Cited by 14 publications

(9 citation statements)

References 21 publications

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“…Thus, anaerobic glycolysis and tissue lactic acid production are stimulated during status epilepticus despite abundant oxygen ((3, 28). Isoflurane has been reported to suppress epileptogenic tissue and decrease the frequency of epileptiform spikes (38,39), which directly relate to lactate content (40). Thus, although lactate production during the NMR study could be suppressed, the lactate observed may have been produced by seizures that occurred before isoflurane administration.…”

Section: Increase Of Lactate Signalmentioning

confidence: 99%

MR spectroscopic imaging and diffusion‐weighted MRI for early detection of kainate‐induced status epilepticus in the rat

Ebisu

Rooney

Graham

et al. 1996

Magnetic Resonance in Med

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Previous studies have shown that reduction of N-acetyl-aspartate (NAA) is correlated with the degree of neuronal loss at 3 days after kainate-induced status epilepticus in the rat. In this study, magnetic resonance spectroscopic imaging (MRSI), measurement of NAA and lactate, T2-weighted MRI, and diffusion-weighted MRI were used to study early alterations in rat piriform cortex at 12 and 26 h after kainate administration. The major findings are that decreased NAA signal, increased lactate signal, and decreased apparent diffusion coefficient (ADC) were observed at 12 h, with little evidence of histological and T2-weighted MRI changes. These results support the hypothesis that NAA, lactate signals, and ADC provide sensitive methods for detection of early and minimal brain damage in vivo.

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Section: Increase Of Lactate Signalmentioning

confidence: 99%

MR spectroscopic imaging and diffusion‐weighted MRI for early detection of kainate‐induced status epilepticus in the rat

Ebisu

Rooney

Graham

et al. 1996

Magnetic Resonance in Med

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“…They also increase cerebral blood flow and ICP while decreasing cerebral oxygen consumption . Isoflurane and desflurane produce dose‐dependent depression of spontaneous epileptiform discharges . In human medicine, the use of IA agents is reserved for the treatment of RSE.…”

Section: Anticonvulsant Therapymentioning

confidence: 99%

Status epilepticus in dogs and cats, part 2: treatment, monitoring, and prognosis

Golubovic

Rossmeisl

2017

J Vet Emergen Crit Care

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Mortality associated with SE is as high as 25% in dogs due to direct and indirect causes of death. Dogs with seizure disorders have a decreased lifespan compared to the general population, and epileptic dogs with SE have a significantly abbreviated lifespan compared to epileptics that do not experience SE. In people, nonconvulsive SE has a higher morbidity and mortality than convulsive SE, regardless of patient age or underlying diagnosis.

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“…[11] Isoflurane produces dose-dependent changes in the EEG. With increasing concentrations, there is a gradual decrease in voltage with increasing periods of electrical silence.…”

Section: Discussionmentioning

confidence: 99%

Volatile anesthetic for the control of posthypoxic refractory myoclonic status

Rayadurg

Radhakrishnan

Rao

2016

Indian Journal of Critical Care Medicine

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Posthypoxic myoclonus (Lance–Adams syndrome) is characterized by myoclonus involving multiple muscle groups which is resistant to most conventional antiepileptic drugs. We present a case of hypoxic brain injury-induced myoclonic status epilepticus successfully controlled with isoflurane. The antimyoclonic effects of isoflurane are likely due to potentiation of inhibitory postsynaptic GABAA receptor–mediated currents and its effects on thalamocortical pathways. It is effective even when intravenous agents fail to control myoclonus. It may be a useful alternative to intravenous anesthetics as a third tier therapy in patients with refractory status myoclonus.

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An experimental study of the effect of isoflurane on epileptiform bursts

Cited by 14 publications

References 21 publications

MR spectroscopic imaging and diffusion‐weighted MRI for early detection of kainate‐induced status epilepticus in the rat

MR spectroscopic imaging and diffusion‐weighted MRI for early detection of kainate‐induced status epilepticus in the rat

Status epilepticus in dogs and cats, part 2: treatment, monitoring, and prognosis

Volatile anesthetic for the control of posthypoxic refractory myoclonic status

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