Mortality following head injury is high. Pre-hospital emergency medical services are disorganized. The key to reducing mortality within the limitations of our current trauma system is maintenance of DBP>70 mmHg and SBP>90 mmHg from the time of first contact.
Posthypoxic myoclonus (Lance–Adams syndrome) is characterized by myoclonus involving multiple muscle groups which is resistant to most conventional antiepileptic drugs. We present a case of hypoxic brain injury-induced myoclonic status epilepticus successfully controlled with isoflurane. The antimyoclonic effects of isoflurane are likely due to potentiation of inhibitory postsynaptic GABAA receptor–mediated currents and its effects on thalamocortical pathways. It is effective even when intravenous agents fail to control myoclonus. It may be a useful alternative to intravenous anesthetics as a third tier therapy in patients with refractory status myoclonus.
The present work is the part of study on Dibenzothiophene (DBT) desulfurizing actinobacteria viz., Streptomyces sp. VUR PPR 101 and Streptomyces sp. VUR PPR 102 isolated from oil contaminated sites of mechanical workshops in Karimnagar area of Andhra Pradesh. Both the species were grown on ten different media including ISP and other media to observe the growth, colour of aerial and substrate mycelia, and of the soluble pigment. The time taken for the onset of sporulation on each medium was also recorded. After incubation, both the species had shown some colour variations in aerial mycelia, substrate mycelia and soluble pigments. Extent of growth was also varied. The time taken for the onset of sporulation slightly varied among different media but not between the bacteria with respect to a particular medium.
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