“…Moreover, these mesenchymal cells eventually form the continuous bands of the future orbicularis oris muscle (Lazzeri et al, ), which is shown to have altered diameter (Khan et al, ; Khan, Little, Abelli, Mossey, et al, ; Khan, Little, Mossey, Steegers‐Theunissen, Bonsi, et al, ) and arrangement (Wijayaweera, Amaratunga, & Angunawela, ) across the two sides in CL cases. Notably, collagen and muscles share structural–functional relationship to ensure proper alignment (Calvi et al, ). Therefore, observation of changes in the orbicularis oris muscles across the two sides could be an outcome of changes in distribution of CF‐ED, which affects the medial side more than the lateral side in cases with CL.…”