An experimental investigation of infective sarcoma of the dog, with a consideration of its relationship to cancer

Wade, Henry

doi:10.1002/path.1700120221

Cited by 31 publications

(17 citation statements)

References 10 publications

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“…Conversely, dogs that have recovered from CTVT have serum-transferable immunity to re-infection (Bellingham Smith and Washbourn, 1898;Crile and Beebe, 1908;Powers, 1968) and puppies born to mothers that have been exposed to CTVT are less susceptible to the disease (Yang and Jones, 1973). The transition from progressive to regressive phases of CTVT growth is accompanied by a marked increase in immune cell infiltration (Wade, 1908;Chandler and Yang, 1981;Hill et al, 1984;Trail and Yang, 1985;Perez et al, 1998;Barber and Yang, 1999;Gonzalez et al, 2000;Chu et al, 2001a;Hsiao et al, 2002;Mukaratirwa et al, 2004Mukaratirwa et al, , 2006.…”

Section: Immunology Of Ctvtmentioning

confidence: 99%

“…Indeed Bellingham Smith and Washbourn (1898) observed that a single CTVT-affected male dog spread the disease to 11 of 12 females, and at least in some regions CTVT is naturally found with greater prevalence in females than in males (Karlson and Mann, 1952;Dass and Sahay, 1989;Scarpelli et al, 2008). If CTVT tumors in males become sufficiently large, they may obstruct preputial retraction (Wade, 1908;Mello Martins et al, 2005). As the penis is required to be unsheathed for coitus, it would be interesting to investigate whether such tumors have reduced transmission.…”

Section: Ctvt Life Cyclementioning

confidence: 99%

“…During the subsequent stable phase, there is markedly slower tumor growth with a doubling time of approximately 20 days, and an estimated cell loss of 80-90% (Cohen and Steel, 1972). Following the stable phase, which can last from weeks to months to indefinitely, up to 80% of CTVT tumors enter a regressive phase during which the tumor shrinks and eventually disappears (Wade, 1908;Epstein and Bennett, 1974;Cohen, 1985;Chu et al, 2001a). The regressive phase generally lasts between 2 and 12 weeks, during which time tumors as large as 100 cm 3 can disappear completely (Wade, 1908;DeMonbreun and Goodpasture, 1934;Karlson and Mann, 1952;Epstein and Bennett, 1974;Cohen, 1985;Chu et al, 2001a).…”

Section: Ctvt Life Cyclementioning

confidence: 99%

“…The regressive phase generally lasts between 2 and 12 weeks, during which time tumors as large as 100 cm 3 can disappear completely (Wade, 1908;DeMonbreun and Goodpasture, 1934;Karlson and Mann, 1952;Epstein and Bennett, 1974;Cohen, 1985;Chu et al, 2001a). Alternatively, rather than entering the regressive phase, between 1 and 20% of transplanted tumors enter a second phase of rapid growth which progresses to metastasis (Wade, 1908;DeMonbreun and Goodpasture, 1934;Karlson and Mann, 1952;Epstein and Bennett, 1974).…”

Section: Ctvt Life Cyclementioning

confidence: 99%

“…Experimentally transferred CTVT tumors have three distinct phases of growth, described as progressive, stable and regressive (Wade, 1908;DeMonbreun and Goodpasture, 1934;Karlson and Mann, 1952;Epstein and Bennett, 1974;Hill et al, 1984;Cohen, 1985;Chu et al, 2001a). Tumors generally become palpable 10-20 days following experimental transfer (Karlson and Mann, 1952;Epstein and Bennett, 1974;Chu et al, 2001a).…”

Section: Ctvt Life Cyclementioning

confidence: 99%

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Clonally transmissible cancers in dogs and Tasmanian devils

2008

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Tasmanian devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT) are the only known naturally occurring clonally transmissible cancers. These cancers are transmitted by the physical transfer of viable tumor cells that can be transplanted across histocompatibility barriers into unrelated hosts. Despite their common etiology, DFTD and CTVT have evolved independently and have unique life histories and host adaptations. DFTD is a recently emerged aggressive facial tumor that is threatening the Tasmanian devil with extinction. CTVT is a sexually transmitted tumor of dogs that has a worldwide distribution and that probably arose thousands of years ago. By contrasting the biology, molecular genetics and immunology of these two unusual cancers, I highlight the common and unique features of clonally transmissible cancers, and discuss the implications of clonally transmissible cancers for host-pathogen evolution.

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Section: Immunology Of Ctvtmentioning

confidence: 99%

Section: Ctvt Life Cyclementioning

confidence: 99%

Section: Ctvt Life Cyclementioning

confidence: 99%

Section: Ctvt Life Cyclementioning

confidence: 99%

Section: Ctvt Life Cyclementioning

confidence: 99%

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Clonally transmissible cancers in dogs and Tasmanian devils

2008

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Detection of humoral antibody to the transmissible venereal tumour of the dog

Cohen

1972

Intl Journal of Cancer

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Humoral antibody against membrane-associutrd antigens of the transrnissiblc. venrrrul tiimoiir ( T V T ) of the dog was drmonstrated using the indirect membratir immiiriofluorescrnce test. Circulating antibody to the turnour, as well as in vivo coating of thc tumour cells with antibody, co~dd br detec-terl at 40 days or more after trunsplantution. Anti-TVT activity was contuined in the 19s. intermediate S and thiJ 7s.jrucfioiw of at1 crnti-T V T swum. No acritiry was iktrcted in the 3SSfractiori. A crossreuctioir wus ctrmortstrutrrl htttwrtw anti-TVT s u o of clitricui cciscs occurring in Irrlutii f U t l d ~laluycr.

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Mononuclear cell content of human solid tumors

Hersh

Mavligit

Gutterman

et al. 1976

Med. Pediatr. Oncol.

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The mononuclear cell content and mononuclear cell function of human solid tumors were determined. Twenty-eight primary, and 17 metastatic solid tumors, including 6 lymph node metastases, were obtained from 45 patients. Cells were released from the tumors by mincing, scraping, and sieving. Analysis of the cellular content was determined by light microscopy, and tumor lymphocyte function was determined by stimulation of blastogenesis with PHA, PWM, Con-A, MLC, and SLO. A median of 3.3 X 10(7) tumor cells with 12.5% viability was obtained per gram of tumor, and a median of 7.8 X 10(6) lymphocytes with a viability of 96% and 0.35 X 10(6) macrophages with a viability of 85% was also obtained per gram of tumor. Significant lymphocyte responses to various mitogens and antigens were obtained in 31-40% of the tumor lymphocyte preparations. From 9.4% to 23% had vigorous responses with a stimulation index greater than 10. Primary tumors contained significantly more lymphocytes than metastatic tumors; thus, the percent lymphocytes in primary tumors was 13.5% compared to 5% for metastatic tumors. In contrast, some of the lymphocyte responses were significantly greater for metastatic tumors than primary tumors. These data suggest that the direct study of lymphocytes infiltrating primary and metastatic tumors may be a useful approach to understanding tumor immunity in man.

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An experimental investigation of infective sarcoma of the dog, with a consideration of its relationship to cancer

Cited by 31 publications

References 10 publications

Clonally transmissible cancers in dogs and Tasmanian devils

Clonally transmissible cancers in dogs and Tasmanian devils

Detection of humoral antibody to the transmissible venereal tumour of the dog

Mononuclear cell content of human solid tumors

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