Detection of humoral antibody to the transmissible venereal tumour of the dog

Cohen, Dan

doi:10.1002/ijc.2910100126

Cited by 28 publications

(20 citation statements)

References 11 publications

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“…Indirect and direct IF studies confirm and extend previous reports of the presence of circulating and cell-bound anti-CTVS antibodies in tumor-bearing dogs [II,19,20]. We noted also that tumor dog sera and even hyperimmune sera reacted only with a proportion of CTVS cells.…”

Section: Discussionsupporting

confidence: 78%

Role of Humoral Immunity in Progressive and Regressive and Metastatic Growth of the Canine Transmissible Venereal Sarcoma

Fenton

Yang²

1988

Oncology

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Canine transmissible venereal sarcoma (CTVS) is a contagious neoplasm which regresses spontaneously in adult dogs but metastasizes and kills puppies transplanted with the neoplasm at a very young age. Immunofluorescence studies showed that 30±14% of cells from steady-state and 22 ± 7% of cells from regressing tumors had membrane-bound antibodies which could be eluted out with warm washes at 24 °C, whereas the cells from progressor tumors had very little such antibody (6 ± 6%). Time-course kinetics of anti-CTVS antibodies in the serum of tumor-bearing dogs did not correlate well with tumor volume, however, the presence of such antibodies in adult dogs (47 ± 13%) but absence (0%) in the puppies with tumor metastasis suggested the importance of antibodies in resistance to metastasis.

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Section: Discussionsupporting

confidence: 78%

Role of Humoral Immunity in Progressive and Regressive and Metastatic Growth of the Canine Transmissible Venereal Sarcoma

Fenton

Yang²

1988

Oncology

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“…Although CTVS cells have been shown previously to be coated with immunoglobulin during the progressive phase of tumour growth (Cohen, 1972;Bennett et al, 1975;Beschorner et al, 1979), the collagenase-dissociated and washed tumour cells used in this study were found to be free of immunoglobulin coating as assayed by immunofluorescence assay, indicating that the failure to demonstrate MHC antigens on progressively growing tumours was not due to masking of tumour cells with immunoglobulins.…”

Section: Discussionmentioning

confidence: 50%

Growth stage dependent expression of MHC antigens on the canine transmissible venereal sarcoma

Yang¹,

Chandler²,

Dunne-Anway³

1987

Br J Cancer

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Summary Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family, such as foxes, coyotes, and wolves. After 2 to 4 months of progressive growth the tumour regresses spontaneously in adults but metastasizes in immunosuppressed hosts and neonates. The mechanisms of how the tumour cells manage to overcome histocompatibility barriers so successfully for such a long period and yet succumb later are not known. In the present study we found that CTVS cells were not stimulatory to the lymphocytes of normal or tumourbearing animals in mixed lymphocyte-tumour reaction (MLTR), although the lymphocytes from tumourbearing hosts responded well to either phytohaemagglutinin (PHA) or third-party allogeneic lymphocytes. Immunofluorescent antibody (IFA) assay of MHC antigens by monoclonal antibodies (MoAb) to monomorphic Class I and Class II MHC antigens showed that progressor tumour cells lacked the expression of the antigens whereas 30 to 40% of regressor tumour cells expressed them.

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“…Although there are significant differences between CTVT and DFT1, they share characteristics of transmissibility and MHC-I downregulation. Indeed the development of IgG antibodies against DFT1 cells may parallel what is believed to occur in CTVT cases: after the canine tumour has established there are increased numbers of MHC-I +ve CTVT cells discernible by immunohistochemistry and immunocytochemistry, and the development of serum IgG antibodies against CTVT cells occurs [8,9]. The experimentally induced CTVTs tend to regress [8], whereas the naturally occurring tumours seem to remain in equilibrium as locally invasive tumours with metastases being uncommon [14].…”

Section: Discussionmentioning

confidence: 99%

Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils

et al. 2016

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Devil facial tumour disease (DFTD) is a recently emerged fatal transmissible cancer decimating the wild population of Tasmanian devils (Sarcophilus harrisii). Biting transmits the cancer cells and the tumour develops in the new host as an allograft. The literature reports that immune escape mechanisms employed by DFTD inevitably result in host death. Here we present the first evidence that DFTD regression can occur and that wild devils can mount an immune response against the disease. Of the 52 devils tested, six had serum antibodies against DFTD cells and, in one case, prominent T lymphocyte infiltration in its tumour. Notably, four of the six devils with serum antibody had histories of DFTD regression. The novel demonstration of an immune response against DFTD in wild Tasmanian devils suggests that a proportion of wild devils can produce a protective immune response against naturally acquired DFTD. This has implications for tumour–host coevolution and vaccine development.

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Detection of humoral antibody to the transmissible venereal tumour of the dog

Cited by 28 publications

References 11 publications

Role of Humoral Immunity in Progressive and Regressive and Metastatic Growth of the Canine Transmissible Venereal Sarcoma

Role of Humoral Immunity in Progressive and Regressive and Metastatic Growth of the Canine Transmissible Venereal Sarcoma

Growth stage dependent expression of MHC antigens on the canine transmissible venereal sarcoma

Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils

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