An experimental and clinical study of the effectiveness of antibiotic wound irrigation in preventing infection

Casten, Daniel F.; Nach, Raphael; J, Spinzia

doi:10.1097/00006534-196502000-00038

Cited by 4 publications

(4 citation statements)

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“…Several models have been used to investigate the pathophysiology of surgical wound infection. Casten et al [3] conducted experiments in which incisions made in rabbit muscle were first contaminated with bacteria and then treated topically by irrigation with different solutions. While 93% of wounds irrigated only with saline became infected, irrigation with a penicillin-containing solution reduced the infection rate to 10%.…”

Section: Experimental Studiesmentioning

confidence: 99%

Irrigation with antibiotic-containing solutions for the prevention and treatment of infections

Falagas

Vergidis

2005

Clinical Microbiology and Infection

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Administration routes for antimicrobial agents used in clinical practice include the topical, inhaled, enteral and parenteral routes. An antibiotic administration route used frequently worldwide, although not well-studied, involves the irrigation of wounds with antibiotic-containing solutions for the prevention and treatment of infections. This review considers the data available from various experimental and clinical studies in order to provide an update on the use of antibiotic-containing solutions in modern clinical practice. Although irrigation with antibiotic-containing solutions has been suggested to be beneficial in the prevention or treatment of infections in several settings and patient populations, no firm, evidence-based recommendations can be made regarding its use until additional data from well-designed, randomised clinical trials become available. Current exceptions include empyema following lobectomy, or pneumonectomy and pyocystis (vesical empyema), since irrigation with solutions containing antimicrobial agents seems to be a crucial component of the management of these conditions.

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Section: Experimental Studiesmentioning

confidence: 99%

Irrigation with antibiotic-containing solutions for the prevention and treatment of infections

Falagas

Vergidis

2005

Clinical Microbiology and Infection

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“…In the group and Bernhang the majority of patients^A CID hiatal hernia in whom there was hyperacidity had an IT associated duodenal ulcer. Casten et al (1963) considered that there was a direct correlation artbum between the size of the hernia and the height of the .artburn--acid; the larger the hernia the higher the acid. Giles, Clark, and Buchan (1968) found that perfusion of the oesophagus with acid produced an increase in the basal gastric secretion in symptomatic hiatal hernia.…”

Section: Resultsmentioning

confidence: 99%

Augmented histamine test in the treatment of symptomatic hiatal hernia

Silber¹

1969

Gut

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(Berman and Berman, 1959;Herrington, 1962). It is the purpose of this paper to indicate that these views have been fallacious and that in fact the pathology and symptoms bear no relation to the height of the basal or maximal acid output. MATERIALS AND METHODSThe augmented histamine test, as described by the Gastrointestinal Service of Groote Schuur Hospital (Marks, Bank, Moshal, and Louw, 1963) was performed in 150 unselected patients with symptomatic hiatal hernia. In this group there were 126 cases of sliding hiatal hernia, eight of composite hiatal hernia, and four of para-oesophageal hiatal hernia. Ninety-one were female and 47 were male patients. An additional 12 patients with sliding hiatal hernia had associated chronic duodenal ulcers. In this latter group were four females and eight males. The age range for the whole group was between 21 and 83 years.These were compared with control and duodenal ulcer groups from the Gastrointestinal Service consisting of 26 females and 35 males in the former group, and 290 females and 1,159 males in the latter group (Bank, Marks, Louw, and Bock, 1967). RESULTSThe basal gastric secretion in the hiatal hernia group is recorded in relation to those with and without heartburn (Fig. 1). A similar comparison is made with the maximal acid output. The hiatal hernias associated with duodenal ulcers were correlated in the same way (Fig. 2).In the hiatal hernia group with heartburn the mean basal output was 2-0 m-equiv/hr compared with 3.3 m-equiv/hr in the group without heartburn and 3 m-equiv/hr in the control group. There was no statistical significant difference in these figures.The mean maximal acid output in the group with 0 om 'U

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“…Nevertheless, injecting antibiotics into joints remains a common practice. There is, in fact, literature that supports the use of local antibiotics from clinical experience dating at least to the early 1940s (13,15) as well as a variety of experimental animal studies (1,2,(4)(5)(6)11,16) and in vitro studies to support the rationale (7-9). Our investigation does not attempt to address the question of whether or not antibiotics should be injected intojoints.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic absorption from infected and normal joints using a rabbit knee joint model

Schurman¹,

Kajiyama²

1985

Journal Orthopaedic Research

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An understanding of the absorption of antibiotics from joints was investigated comparing intraarticular (i.a.) absorption with intramuscular (i.m.) absorption in a rabbit knee model. The antibiotics investigated were methicillin, cephalothin, cefazolin, cefoxitin, amikacin, neomycin, kanamycin, and gentamicin. Absorption was measured both in animals in which the knee joint was infected with Staphylococcus aureus and in normal animals. The pattern of absorption was similar among different antibiotics. On an average, antibiotics are absorbed from infected joints 37% slower than from an i.m. injection. In animals that are not infected i.a. antibiotics are actually absorbed 12% faster than i.m. antibiotics. Thus, i.a. antibiotics are absorbed rapidly and similarly to i.m. injection and should be included in total dose calculations for antibiotic regimens, especially with regard to their potential toxicity.

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An experimental and clinical study of the effectiveness of antibiotic wound irrigation in preventing infection

Cited by 4 publications

References 0 publications

Irrigation with antibiotic-containing solutions for the prevention and treatment of infections

Irrigation with antibiotic-containing solutions for the prevention and treatment of infections

Augmented histamine test in the treatment of symptomatic hiatal hernia

Antibiotic absorption from infected and normal joints using a rabbit knee joint model

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