Nowadays, rapid increase in vehicle population led to increase in demand of fossil fuel. Decrease in availability of crude oil made the researchers to find a renewable alternative fuel, biofuels. Methyl esters are preferred as alternative to petro‐diesel engines. The present experimental study of Mimusops elangi methyl ester (MEME) is used as biodiesel on single cylinder four stroke, direct injection air cooled diesel engine at a constant speed of 1500 rpm at various loads. The general optimum biodiesel blends 20MEME‐80D (20%MEME‐80%Diesel) with optimum of 25 ppm TiO2 nanoparticle additives were taken for the experiment. The injection pressure of the engine is varied from 180 bar to 240 bar in the steps of 20 bar. The results of experimental investigation reported that the change in injection pressure 220 bar with modified fuel (20MEME‐80D + 25 ppm TiO2 nanoparticle) shows better performance and emission characteristics in the diesel engine. © 2019 American Institute of Chemical Engineers Environ Prog, 38:e13146, 2019