An expanded dengue syndrome patient with manifestation myocarditis: case report

Arifijanto, Muhammad Vitanata; Luqmana, H P; Rusli, Musofa; Bramantono,

doi:10.1088/1755-1315/125/1/012094

Cited by 2 publications

(2 citation statements)

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“…Only one case is documented so far in literature. [14] The exact pathophysiology of subacute intestinal obstruction is not known. Probably, it occurs due to edema of intestinal wall.…”

Section: Discussionmentioning

confidence: 99%

Clinicolaboratory profile of expanded dengue syndrome – Our experience in a teaching hospital

Mohanty

Sunder

Pathak

2019

J Family Med Prim Care

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Introduction: Classic dengue fever presentation has expanded its horizon by involving various organ systems and is named as expanded dengue syndrome. This changing presentation and rising burden across the globe may lead to delayed diagnosis and under reporting of this syndrome. Aim of Study: To analyze clinicolaboratory profile of patients with expanded dengue syndrome. Materials and Methods: About 520 cases of expanded dengue syndrome as per World Health Organization definition criteria 2012 were studied with their informed consent. Detailed history, thorough clinical examination, and relevant investigations were done. Their clinical and laboratory parameters were analyzed. Standard treatment guidelines were followed in all cases. Observation: About 301 patients were male and 219 were female with male-to-female ratio of 3:2. Their age varied from 12 to 76 years with the average age of 47.5 years. About 92% of cases presented with various gastro hepatic manifestations. The commonest gastrohepatic manifestation was transaminitis (57.5%) that is asymptomatic elevation of liver enzymes followed by acalculous cholecystitis (21%) and acute pancreatitis (13.9%). Twenty-nine patients presented with various neurological manifestations. Three patients presented with acute kidney injury and eight patients had coinfection with malaria. Fever with nausea and vomiting was the most common presentation. About 15% of patients presented with bleeding manifestations. About 40.6% of patients presenting as abdominal manifestations had platelet count <20,000/mm 3 and needed platelet transfusion versus 9.8% with other system involvement (central nervous system, cardiovascular system (CVS), renal). Hepatomegaly was the most common ultrasonography (USG) finding being present in 57.5% of patients followed by acalculous cholecystitis in 21.3%. Total mortality was 1.9% in our series. We lost eight patients presenting with neurological manifestations and two patients with coinfection with malaria. Conclusion: Atypical presentations should prompt us to investigate for dengue especially during ongoing epidemics so that expanded dengue syndrome can be diagnosed and treated early.

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“…Only one case is documented so far in literature. [14] The exact pathophysiology of subacute intestinal obstruction is not known. Probably, it occurs due to edema of intestinal wall.…”

Section: Discussionmentioning

confidence: 99%

Clinicolaboratory profile of expanded dengue syndrome – Our experience in a teaching hospital

Mohanty

Sunder

Pathak

2019

J Family Med Prim Care

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“…Dengue myocarditis has been described using various diagnostic criteria, in some case reports and small case series from endemic areas (Yacoub et al, 2014). Arifijanto et al reported an 18 years old woman with acute myocarditis due to DVI based on laboratory findings, including thrombocytopenia hemoconcentration, with positive results for NS1 and dengue IgM, IgG examination, elevated CKMB, elevated troponin, and hyperechogenic cardiographic features (Arifijanto et al, 2018). However, very few patients with dengue have a formal cardiac assessment, so the frequency of subclinical dengue myocarditis and its relative contribution to the hemodynamic instability in severe dengue remains to be demonstrated (Marques et al, 2013) The pericardium can also be affected by dengue, but less frequently than the myocardium, with very few reports of isolated dengue pericarditis (Daniel et al, 2013).…”

Section: Organ-specific Manifestation Cardiac Manifestationsmentioning

confidence: 99%

Expanded Dengue Syndrome

Vincent

Bramantono

Hadi

et al. 2022

CIMRJ

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Dengue viral infection (DVI) is a debilitating arthropod-borne disease that has been rapidly spread in several regions of the world in recent years. The spectrum of disease varies from mild self-limiting illness to dengue fever (DF) to more severe and fulminating forms, i.e., dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS),and expanded dengue syndrome (EDS). The pathogenesis of EDS is not clear amid lack of studies on animal models. In the absence of in vitro experiments, disease spectrum is difficult to be elucidated and mimicked for humans.Recent advances on research on atypical complications of EDS demonstrate the involvement of other major organs such as the kidney, lung, heart, and central nervous system. Histopathological findings demonstrate the presence of hemorrhage, edema, and inflammatory infiltrates in these organs.The spectrum of Dengue viral infection varies from mild self-limiting illness to dengue fever to more severe and fulminating forms, i.e., dengue hemorrhagic fever, dengue shock syndrome, and expanded dengue syndrome. Apart from the classical presentation, dengue infection can result in a myriad of unusual clinical manifestations, which are grouped under the title expanded dengue syndrome. These findings urge more focused and comprehensive investigations to explore such relationships so that high-risk patients could be identified immediately during their presentation to the hospitals.Keywords: Expanded dengue syndrome, Pathogenesis, Organ-specific manifestation

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An expanded dengue syndrome patient with manifestation myocarditis: case report

Cited by 2 publications

References 5 publications

Clinicolaboratory profile of expanded dengue syndrome – Our experience in a teaching hospital

Clinicolaboratory profile of expanded dengue syndrome – Our experience in a teaching hospital

Expanded Dengue Syndrome

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