“An exophytic mandibular brown tumor”: an unusual presentation of primary hyperparathyroidism

Angadi, Punnya V.; Rekha, K.; Shetty, Smitha Sammith

doi:10.1007/s10006-009-0186-0

Cited by 12 publications

(9 citation statements)

References 12 publications

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“…Classic skeletal lesions are bone resorption, bone cysts, brown tumors and generalized osteopenia [6]. Brown tumors are non neoplastic lesions resulting from abnormal bone metabolism in hyperparathyroidism [9]. They have been described in both primary (4.5% of patients with primary hyperparathyroidism) and secondary hyperparathyroidism (1.5-1.7% of patient with secondary hyperparathyroidism) as resulting from an imbalance of osteoclastic and osteoblastic activity with bone resorption exceeding the bone formation [10,11].…”

Section: Discussionmentioning

confidence: 99%

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Brown tumor of the palate as first manifestation of primary hyperparathyroidism: a case report

Chami¹,

Benrachadi

Omri

et al. 2011

Med Buccale Chir Buccale

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-Brown tumor is one of the lesions that develop in patients with hyperparathyroidism. Skeletal bones including maxillo-facial ones can be the site of this lesion. Owing to the improve methods of blood analysis most of cases of primary hyperparathyroidism are diagnosed early and asymptomatically making advanced disease with bone lesions extremely rare. This article contains a case of a 43-year-old female patient who presented with palatal swelling as the first sign of primary hyperparathyroidism. The diagnosis was suggested by the histological findings and confirmed by the endocrinologic status.Résumé -Tumeur brune du palais comme première manifestation d'un hyperparathyroïdisme primaire. Présentation d'un cas. La tumeur brune représente une des lésions que l'on peut observer dans l'hyperparathyroïdisme. Elle touche les os, y compris ceux de la région maxillo-faciale. Le bilan biologique permet de diagnostiquer la plupart des cas d'hyperparathyroïdisme primaire à un stade précoce ; les formes évoluées asymptomatiques sont extrémement rares. Cet article présente un cas d'hyperparathyroïdisme primaire, chez une femme de 43 ans, où la première manifestation était constituée par une tuméfaction palatine. Le diagnostic a été évoqué à l'examen histologique et confirmé par le bilan endocrinien.

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Section: Discussionmentioning

confidence: 99%

“…The ribs, clavicles, and pelvis are the sites of predilection of this lesion [11]. Jaw involvement is extremely rare with mandible the most common site than maxillary [9,11].…”

Section: Discussionmentioning

confidence: 99%

Brown tumor of the palate as first manifestation of primary hyperparathyroidism: a case report

Chami¹,

Benrachadi

Omri

et al. 2011

Med Buccale Chir Buccale

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“…The pathologically similar giant cell tumors often have indistinct borders and blend into the normal bone, a finding that may serve to distinguish them from brown tumors (1,10,11,12,(22)(23)(24). Characteristic radiographic finding of HPT can also be found in patients with brown tumors such as widespread loss of lamina dura, and subperiosteal erosion of phalanges (2,22,23,25). However, occasionally a solitary brown tumor is the only skeletal manifestation of HPT (22), as in our cases two and three.…”

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confidence: 66%

“…There are, however, instances where patients with primary HPT have normal total and/or ionized serum calcium levels or intermittent hypercalcemia (5,15,16,24). Brown tumor is extremely rare in normocalcemic primary HPT (2,5,6,8,24). Only 8 cases have been reported so far in the English literature (Table I).…”

Section: Introductionmentioning

confidence: 99%

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Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

Khalatbari¹,

Hamidi²,

Moharamzad³

et al. 2011

Turkish Neurosurgery

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Brown tumor is a bone lesion secondary to hyperparathyroidism of various etiologies. Skeletal involvement in primary hyperparathyroidism secondary to parathyroid adenoma is very uncommon and brown tumor has become extremely a rare clinical entity. Hyperparathyroidism is usually associated with high levels of serum calcium. Brown tumor as the only and initial symptom of normocalcemic primary hyperparathyroidism is extremely rare. Moreover, involvement of the skull base and the orbit is exceedingly rare. The authors would report three cases of brown tumor of the anterior skull base that were associated with true normocalcemic primary hyperparathyroidism. Clinical manifestations, neuroimaging findings, pathological findings, diagnosis and treatment of the patients are discussed and the relevant literature is reviewed. KeywoRds: Brown tumor, Skull base, Normocalcemia, Primary hyperparathyroidism ÖZKahverengi tümör çeşitli etiyolojiler nedenli hiperparatiroidiye sekonder bir kemik lezyonudur. Paratiroid adenomuna sekonder primer hiperparatiroidide iskelet tutulumu çok nadirdir ve kahverengi tümör çok nadir bir klinik olay haline gelmiştir. Hiperparatiroidi genellikle yüksek serum kalsiyum düzeyleriyle ilişkilidir. Normokalsemik primer hiperparatiroidinin tek ve başlangıç belirtisi olarak kahverengi tümör çok nadirdir. Ayrıca kafatası tabanı ve orbitanın tutulması son derece nadirdir. Yazarlar gerçek normokalsemik primer paratiroidi ile ilişkili anterior kafatası tabanının üç kahverengi tümör vakasını sunmaktadır. Klinik bulgular, nörogörüntüleme bulguları, patolojik bulgular ve bu hastaların tanı ve tedavisi sunulmakta ve ilgili literatür gözden geçirilmektedir.

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A rare manifestation of renal osteodystrophy in a non-compliant child on hemodialysis: Answers

et al. 2015

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“An exophytic mandibular brown tumor”: an unusual presentation of primary hyperparathyroidism

Cited by 12 publications

References 12 publications

Brown tumor of the palate as first manifestation of primary hyperparathyroidism: a case report

Brown tumor of the palate as first manifestation of primary hyperparathyroidism: a case report

Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

A rare manifestation of renal osteodystrophy in a non-compliant child on hemodialysis: Answers

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