An Event-Driven Motion Correction Method for Neurological PET Studies of Awake Laboratory Animals

Zhou, Victor; Kyme, Andre; Meikle, Steven R.; Fulton, Roger

doi:10.1007/s11307-008-0157-0

Cited by 44 publications

(23 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Motion correction algorithms have been studied across various modalities, including functional magnetic resonance imaging (fMRI) [8,9], positron emission tomography (PET) [10,11], emission computed tomography (ECT) [12], optical cardiac/ophthalmic imaging [13–17] and structural OCT imaging [18,19]. Most of these studies have employed external systems such as optical motion tracking systems [8–12, 16,17] or motion-gating electronics [15].…”

Section: Introductionmentioning

confidence: 99%

Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex

Lee¹,

Srinivasan²,

Radhakrishnan³

et al. 2011

Opt. Express

View full text Add to dashboard Cite

Cardiac and respiratory motions in animals are the primary source of image quality degradation in dynamic imaging studies, especially when using phase-resolved imaging modalities such as spectral-domain optical coherence tomography (SD-OCT), whose phase signal is very sensitive to movements of the sample. This study demonstrates a method with which to compensate for motion artifacts in dynamic SD-OCT imaging of the rodent cerebral cortex. We observed that respiratory and cardiac motions mainly caused, respectively, bulk image shifts (BISs) and global phase fluctuations (GPFs). A cross-correlation maximization-based shift correction algorithm was effective in suppressing BISs, while GPFs were significantly reduced by removing axial and lateral global phase variations. In addition, a non-origin-centered GPF correction algorithm was examined. Several combinations of these algorithms were tested to find an optimized approach that improved image stability from 0.5 to 0.8 in terms of the cross-correlation over 4 s of dynamic imaging, and reduced phase noise by two orders of magnitude in ~8% voxels.

show abstract

Section: Introductionmentioning

confidence: 99%

Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex

Lee¹,

Srinivasan²,

Radhakrishnan³

et al. 2011

Opt. Express

View full text Add to dashboard Cite

show abstract

“…Although a specially designed PET scanner [30] or continuous motion tracking method with a slight amount of movement restriction [31] have been suggested for the PET scans of unanesthetized animals, they have not been practical for use to date. Therefore, the proper choice of the methods used as well as the minimal use of anesthesia remains the most important issues to consider for animal PET imaging studies, and the minimization of the time for the total PET study is regarded as one of the most important factors for use of this technology on animals.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of Template-Guided Attenuation Correction in Cat Brain PET Imaging

et al. 2009

View full text Add to dashboard Cite

show abstract

“…[ [18] and images were reconstructed using ordered-subsets expectation maximization [43]. The location of the central voxel of the brain was identified from the reconstruction and its trajectory throughout the scan computed based on the known motion.…”

Section: Bþmentioning

confidence: 99%

Tracking and characterizing the head motion of unanaesthetized rats in positron emission tomography

Kyme

Meikle

Baldock

et al. 2012

J. R. Soc. Interface.

Self Cite

View full text Add to dashboard Cite

Positron emission tomography (PET) is an important in vivo molecular imaging technique for translational research. Imaging unanaesthetized rats using motion-compensated PET avoids the confounding impact of anaesthetic drugs and enables animals to be imaged during normal or evoked behaviour. However, there is little published data on the nature of rat head motion to inform the design of suitable marker-based motion-tracking set-ups for brain imaging-specifically, set-ups that afford close to uninterrupted tracking. We performed a systematic study of rat head motion parameters for unanaesthetized tube-bound and freely moving rats with a view to designing suitable motion-tracking set-ups in each case. For tube-bound rats, using a single appropriately placed binocular tracker, uninterrupted tracking was possible greater than 95 per cent of the time. For freely moving rats, simulations and measurements of a live subject indicated that two opposed binocular trackers are sufficient (less than 10% interruption to tracking) for a wide variety of behaviour types. We conclude that reliable tracking of head pose can be achieved with marker-based opticalmotion-tracking systems for both tube-bound and freely moving rats undergoing PET studies without sedation.

show abstract

An Event-Driven Motion Correction Method for Neurological PET Studies of Awake Laboratory Animals

Abstract: This work is an important step towards motion tracking and motion correction in neurological studies of awake animals in the small animal PET imaging environment.

Cited by 44 publications

References 15 publications

Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex

Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex

Feasibility of Template-Guided Attenuation Correction in Cat Brain PET Imaging

Tracking and characterizing the head motion of unanaesthetized rats in positron emission tomography

Contact Info

Product

Resources

About