An evaluation of the predictive validity and inter‐rater reliability of clinical diagnostic criteria for senile dementia of Lewy body type

McKeith, IG; Fairbairn, Andrew; Bothwell, Robert; Moore, P. A.; Ferrier, I. N.; Thompson, Peter M.; Perry, R. H.

doi:10.1212/wnl.44.5.872

Cited by 161 publications

(87 citation statements)

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“…We anticipate the clinical diagnosis to be accurate in an estimated 90 % of our cases, based on studies of the sensitivity and specificity of similar standardized diagnostic criteria used previously (Boller et al 1989 ;McKeith et al 1994). This is supported by our clinical diagnoses, which were correct in six of the seven cases for which we had neuropathological data.…”

Section: Discussionsupporting

confidence: 68%

Magnetic resonance imaging differences between dementia with Lewy bodies and Alzheimer's disease: a pilot study

et al. 1999

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Section: Discussionsupporting

confidence: 68%

Magnetic resonance imaging differences between dementia with Lewy bodies and Alzheimer's disease: a pilot study

et al. 1999

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“…However, many prospective clinicopathological studies have since shown that AD is the most common cause of dementia in the elderly (8). Based on recent clinicopathological studies, dementia with Lewy bodies (DLB) has emerged as the second most common degenerative pathology associated with dementia, accounting for 10 -25% of all cases (9)(10)(11)(12). Vascular pathology now appears to be the third most common cause of dementia, accounting for roughly one-fifth of the number of dementia cases (13,14).…”

Section: Introductionmentioning

confidence: 99%

The validity of clinical diagnoses of dementia in a group of consecutively autopsied memory clinic patients

Taylor

Hohl

Tolnay

et al. 2008

The Journal of nutrition, health and aging

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Abstract:Background: Epidemiological studies show that up to 10 % of individuals aged 65 years and older suffer from dementia, most commonly from dementia of the Alzheimer Type (DAT) [1]. Clinicopathological studies are critical to our understanding of this disease and improving the accuracy of clinical diagnoses. Objectives: Our objectives were to examine the validity of clinical diagnoses of DAT, to determine the prevalence of different forms of dementia in this sample, and to investigate the relationship between age at death and polymorbidity. Subjects and method: Clinical data were available from 221 patients who had been examined at the Basel Memory Clinic between 1986 and 1996. From this population, 34 % (75 patients) were autopsied in the Department of Pathology, University Hospital Basel, and neuropathological examinations were additionally performed on 62 (83 %) of these patients. Clinical and neuropathological data were retrospectively compared. Results: 67.8 % of the neuropathologically examined patients received a definitive diagnosis of AD (Alzheimer's disease), vascular dementia (VaD) or mixed dementia (AD and VaD). AD alone or with other histopathological hallmarks of dementia was the most prevalent neuropathological diagnosis (63 %). VaD was deemed the only cause of dementia in only 4.8 % of patients. The sensitivity for DAT was 75.9 %, the specificity 60.6 %. Increasing age was associated with an increasing number of clinical and neuropathological diagnoses. Conclusion:The sensitivity and specificity of the clinical diagnoses of DAT found in our study are similar to previous reports (2-5). Older patients had more etiologies of their dementia than younger patients. This study reaffirms the need for internationally accepted criteria for clinical and neuropathological diagnoses, as well as further clinical-neuropathological investigations to further refine the clinical diagnostic process.

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“…There is a potential overlap between the two disorders. 26 Lewy body dementia is among those conditions persons with nonamnestic MCI might progress to. 2 Consequently, the prevalence of nonamnestic MCI might have been slightly underestimated in this study.…”

Section: 2mentioning

confidence: 99%

Minocycline-induced skin and dental pigmentations

Mozaffar¹,

Gordon²

2006

Neurology

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Abstract-Objective:To empirically validate the expanded concept of mild cognitive impairment (MCI), which differentiates between four clinical subtypes-amnestic MCI-single domain, amnestic MCI-multiple domains, nonamnestic MCIsingle domain, and nonamnestic MCI-multiple domains-and to examine the prevalence, course, and outcome of these four clinical MCI subtypes. Methods: We studied a community sample of 980 dementia-free individuals aged 75 years or older who participated in the Leipzig Longitudinal Study of the Aged (LEILA 75ϩ). All participants were examined by neuropsychological testing based on 6 years of observation. The diagnoses of the four clinical MCI subtypes were made according to the original and to slightly modified criteria by Petersen et al. (2001) (both with a cutoff of 1.0 SD and with a cutoff of 1.5 SD). The complete range of outcome types (dementia, death, improvement, stable diagnosis, unstable diagnosis) was described for all subtypes. The relative predictive power of stable MCI for dementia onset was determined. Results: MCI-single domain is more frequent than MCI-multiple domains, and the nonamnestic MCI type is as frequent as the amnestic MCI type. The "MCI modified, 1.0 SD" criteria have the highest relative predictive power for the development of dementia (sensitivity ϭ 74%, specificity ϭ 73%). Alzheimer disease (AD) was the most common type of dementia at follow-up in all but one MCI subtype. Participants with nonamnestic MCI-multiple domains were more likely to progress to a non-AD dementia. Conclusions: It has been assumed that each MCI subtype is associated with an increased risk for a particular type of dementia. We can only partially agree with this. NEUROLOGY 2006;67:2176-2185 The expanded concept of mild cognitive impairment (MCI) distinguishes four clinical subtypes: amnestic MCI-single domain, amnestic MCI-multiple domains, nonamnestic MCI-single domain, and nonamnestic MCI-multiple domains. 1,2These four clinical subtypes assumedly differ in etiology and outcome.1,2 Amnestic MCI (single domain as well as multiple domains) is said to have a high likelihood of progressing to Alzheimer disease (AD) dementia. The nonamnestic subtypes are assumed to have a higher likelihood of progressing to a non-AD dementia. 1,2This study addresses several questions. What is the prevalence of the subtypes of MCI? Which types of dementia do the subtypes of MCI commonly relate to? In this study, we also examine the course of and 6-year outcome of MCI in a representative general population sample aged 75 years and older, and describe the complete range of outcome types (dementia, death, improvement, stable diagnosis, unstable diagnosis).Method. Sample. The data were derived from the Leipzig Longitudinal Study of the Aged (LEILA 75ϩ), a population-based study of the epidemiology of dementia and MCI.3 All subjects gave written informed consent to participate in this study. The local ethics committee approved this study. The total LEILA 75ϩ sample was comprised of a total of 1,692 community-dwelling ...

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An evaluation of the predictive validity and inter‐rater reliability of clinical diagnostic criteria for senile dementia of Lewy body type

Cited by 161 publications

References 0 publications

Magnetic resonance imaging differences between dementia with Lewy bodies and Alzheimer's disease: a pilot study

Magnetic resonance imaging differences between dementia with Lewy bodies and Alzheimer's disease: a pilot study

The validity of clinical diagnoses of dementia in a group of consecutively autopsied memory clinic patients

Minocycline-induced skin and dental pigmentations

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